Phytochemical and Toxicological Studies of An Aqueous Trunk Bark Extract of Parkia biglobosa (Jacq.) Benth (Mimosaceae)

Kassi, Yomalan; Konaté, Kiessoun; Bi, Semi Anthelme Nene; Souza, Alain; Ehile, Etienne Ehouan

doi:10.25258/phyto.v10i03.11938

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…These results are similar to those obtained with many medicinal plants in the African pharmacopoeia, such as Crotalaria retusa L (Fabaceae) [9], Parkia biglobosa (Mimosaceae), [10] Annona senegalensis (Annonaceae) and Hallea senegalensis (Rubiacaceae) [11].…”

Section: Discussionsupporting

confidence: 86%

Hypoglycaemic Effects of an Aqueous Leaves Extract of Combretum micranthum in Normoglycaemic Rats

Anderson-Bel,

Stanislas,

Christelle

et al. 2024

EJMP

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Background: In order to promote the Ivorian pharmacopoeia, we undertook the study of Combretum micranthum (Combretaceae), a plant commonly used in Ivory Coast for the treatment of diabetes. The aim of this study was to evaluate the hypoglycemic effects of an aqueous leaves extract of Combretum micranthum (EaqCM) in Wistar rats. Methods and Materials: A phytochemical screening study was performed. The pharmacological test on normoglycaemic rats was carried out in 4 groups of 5 rats per group. Rats in group 1 received 2 ml of distilled water, and rats in the test groups received doses ranging at 100 to 300 mg/kg B.W. of the EAqCM. Tests in pre-treated temporarily hyperglycemic rats were performed in 4 groups of 5 rats per group. The rats in groups 1 and 2 received 2ml of distilled water, the rats in test groups (3 and 4) received the dose of 10-2g/kg B.W. and 100 mg/kg B.W. respectively glibenclamide and EAqCM. Thirty minutes later, all rats except those in group 1 received anhydrous glucose. The protocol for testing post-treated hyperglycaemic rats is the same as that for pretreated rats, except that in this experiment glucose is administered to the animals before the test substances. Blood glucose is measured in the rats at regular intervals of 30, 60, 90, 120, 150, and 180 minutes after administration of the substances. Results: Qualitative phytochemical analysis of EAqCM revealed the presence of polyphenols, flavonoids, catechic, tannins, quinonic compounds, alkaloids, sterols, and polyterpenes. Pharmacological tests on the glycemia of normoglycemic rats showed that EAqCM has hypoglycemic properties at a dose of 100 mg/kgB.W. with a percentage reduction of 30%. In hyperglycemic rats, EAqCM and glibenclamide exhibited anti-hyperglycemic activity with respective percentages reduction of 57.47 % and 58.82 %. Conclusion: Antihyperglycemic effect of EAqCM in post-treated rats would probably be due to the presence of polyphenols and flavonoids in this extract. These results support the use of this plant in traditional medicine for the treatment of diabetes.

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Section: Discussionsupporting

confidence: 86%

Hypoglycaemic Effects of an Aqueous Leaves Extract of Combretum micranthum in Normoglycaemic Rats

Anderson-Bel,

Stanislas,

Christelle

et al. 2024

EJMP

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“…The dehulled seed contains about 42% protein, 24% lipids, 20% carbohydrate, 9% fiber, and about 462 kcal/100 g (Hassan & Umar, 2004). Phytochemical screening shows that it contains polyterpenes, polyphenols flavonoids, catechictannins, saponin, and sterols (Kassi et al, 2018). Oil from of Parkia biglobosa seed have been reported to contain arachidic, stearic, palmitic, behenic, and linoleic acids (Balogun et al, 2018).…”

Section: Parkia Biglobosamentioning

confidence: 99%

“…It is used in traditional medicine for treating jaundice, pneumonia, wounds, eye infection, hypertension, diabetes, diarrhea, leprosy, chicken pox, measles, tooth decay, hernia, hemorrhoids, osteopathies, mumps, microbial infection and many other diseases (Kassi et al, 2018). Pharmacologically, it has been reported to possess hypoglycemic (Okaiyeto et al, 2021), anti-oxidants (Sunmonu and Lewu, (2019), antibacterial (Abioye et al, 2013), antihypertensive, hypolipidemia (Ayo-Lawal et al, 2012 and anti-inflammatory activities (Ukwuani & Ahmad, 2015).…”

Section: Parkia Biglobosamentioning

confidence: 99%

A review of some common African spices with antihypertensive potential

Adeoye

Joel

Igunnu

et al. 2021

Journal of Food Biochemistry

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Hypertension is the most common non-communicable disease, with about 1.28 billion hypertensive people worldwide. It is more prevalent in men than women and more common in the elderly. Hereditary, age, obesity, lifestyle, diet, alcohol, and chronic metabolic diseases are the major risk factors of hypertension. Treating hypertension is a complex process as there are several mechanisms responsible for its pathogenesis; hence, a combination of several drugs is used for managing hypertension. Drugs used in managing hypertension are expensive and often come with associated side effects; thus, there is need for alternative means of managing this life-threatening disease. These drugs do not achieve the recommended blood pressure target in most people; more so majority of people with hypertension do not follow the treatment regimen religiously. Some Africans have been reported to become normotensive as a result of dietary consumption of spices. Several spices have been used over the years in Africa to manage hypertension. The aim of this review is to evaluate the ethnomedicinal use, bioactive phytochemical composition, bioactive compounds present, and pharmacological applications of spices commonly used in Africa for managing hypertension. Most of the plants used contained polyphenols, flavonoids, tannins, anthraquinone, flavonoids, cardiac glycosides, and saponins. Dietary supplementation of Xylopia aethiopica and other spices in diet have been proven to significantly reduced plasma angiotensin-I-converting enzyme (ACE) than simvastatin (the reference drug). Toxicological, histological, and hematological evaluation revealed that acute and chronic consumption of most of these spices are safe. Studies have also revealed that some of the spices can be used as alternative therapy alongside usual antihypertensive medications. Practical implication:The prevalent rate of hypertension is on the increase in both the developed and developing countries. People often skip medication due to their busy schedule and anti-hypertensive potential side effects; however, this is not the case with food/spices as most people consumed them daily. Deliberate, right combinations and consistent incorporation of spices with proven anti-hypertensive potential into our diet may be of great benefit in normalizing blood pressure and mitigate other complications on the heart and vital organs.Hypertension or elevated blood pressure means the persistent force of blood against the artery wall leading to increase in blood pressure. According to World Health Organisation (WHO, 2021), blood pressure on two different days with both days exceeding 140/90 mmHg is classified as hypertension. The first (higher) number is the systolic, which is the blood pressure when the heart contracts, while the second (lower number) is the diastolic, which is the blood pressure when the heart relaxes (Ondimu et al., 2019). It is usually measured using upper arm cuff; however wrist devices are used for obese persons with extreme size of the arm (Nerenberg et al., 2018). Accordi...

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Parkia biglobosa (Mimosaceae): Botany, Uses, Phytochemical Properties and Pharmacological Potential

Musara

Aladejana

Mudyiwa

et al. 2020

J. Pharm. Nutr. Sci.

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Parkia biglobosa (Jacq.) R. Br. ex G. Don, popularly known as the African locust bean tree, is a perennial tree legume that belongs to Mimosoïdeae sub-family and family of Fabaceae. This study is aimed at reviewing the botany, nutritional uses, phytochemical and pharmacological properties of P. biglobosa and the information was undertaken using electronic databases such as Scopus, Google Scholar, Elsevier, Science Direct, Web of Science, Pubmed, SciFinder, BMC and Open-thesis. Parkia biglobosa is a very important multipurpose tree that is used essentially for food, medicinal, cultural, economic and magico-therapeutic purposes. Due to its socio-economic and cultural importance, P. biglobosa species are vulnerable to unsustainable harvesting and are declining in numbers because they remain semi- or undomesticated in some west Africa countries. Different aqueous and organic extracts of P. biglobosa indicate that the species are rich in saponins, tannins, flavonoids, resins, carbohydrates, terpenoids, phenols, sterols, and cardiac glycosides. The nutritional and pharmacological benefits of P. biglobosa has been associated with its physicochemical properties. Pharmacological studies on P. biglobosa exhibited antimalarial, anti-helminthic, antibacterial, antidiabetic, antihypertensive, anti-inflammatory, analgesic, anti-carcinogenic, anti-trypanosomic activities and antioxidant properties. Threats to the survival of this multipurpose species are also highlighted.

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Phytochemical and Toxicological Studies of An Aqueous Trunk Bark Extract of Parkia biglobosa (Jacq.) Benth (Mimosaceae)

Cited by 3 publications

References 14 publications

Hypoglycaemic Effects of an Aqueous Leaves Extract of Combretum micranthum in Normoglycaemic Rats

Hypoglycaemic Effects of an Aqueous Leaves Extract of Combretum micranthum in Normoglycaemic Rats

A review of some common African spices with antihypertensive potential

Parkia biglobosa (Mimosaceae): Botany, Uses, Phytochemical Properties and Pharmacological Potential

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