Phytochemical, Antidiabetic, and Cytoprotective Properties of Berberis aristata DC. Root Extracts

Mittal, Manjari

doi:10.2174/2210290601203010064

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…Results of the qualitative phytochemical analysis are shown in Table 1. It is important to note that our results are consistent with those described for B. asiatica [15], B. aristata [14], B. tinctoria [27], and B. lyceum [28].…”

Section: Resultssupporting

confidence: 91%

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Phytochemical Constituents of the Root of Berberis Microphylla

Furrianca

Alvear

Zambrano

et al. 2017

Asian J Pharm Clin Res

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Objective: To objective of this work was to perform phytochemical qualitative and quantitative analyzes of the main secondary metabolites in the root of Berberis microphylla. Methods:The extracts of B. microphylla root were tested through phytochemical screening and the quantification of the most important constituents was carried out using spectrophotometric and gravimetric techniques.Results: Phytochemical screening of both extracts showed the presence of alkaloids, flavonoids, glycosides, cardiac glycosides, saponins, terpenes, and tannins, which are pharmacologically important. Quantification of the major phytochemicals groups showed that the ethanolic extract contains 3.9% alkaloids, 0.46% flavonoids, 9.53% tannins, and 3.60% saponins. Similarly, the methanolic extract contains 6.61% alkaloids, 0.41% flavonoids, 7.40% tannins, and 1.43% saponins. Conclusion:This is the first time that the presence of tannins, flavonoids, and saponins in this plant has been reported. The medicinal properties of the root of B. microphylla may exist due to the presence secondary metabolites.

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Section: Resultssupporting

confidence: 91%

“…The major phytochemical studies have been conducted on Asian species, such as Berberis jaeschkeana, Berberis asiatica, Berberis aristata, and Berberis lyceum. These species showed a relatively high content of tannins, saponins, alkaloids, flavonoids, steroids, phenolic compounds, and carbohydrates [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Constituents of the Root of Berberis Microphylla

Furrianca

Alvear

Zambrano

et al. 2017

Asian J Pharm Clin Res

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“…Polyherbal extract contains good amount of alkaloids because it contains Annona squamosa and Berberis aristata which are rich in alkaloid contents [29,30]. Total alkaloid content found in Annona squamosa after extraction was 0.82% w/w.…”

Section: Discussionmentioning

confidence: 99%

Standardization of Polyherbal Extract for Type-2 Diabetes

Mittal

Juyal

Singh

2015

J. Pharm. Nutr. Sci.

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Aims: This study was aimed to standardize the polyherbal extract containing Annona squamosa, Phyllanthus emblica, Berberis aristata and Curcuma longa for the management of type-2 diabetes. The standardization of polyherbal formulation is indispensable in order to achieve the quality, purity, safety and efficacy of drugs. Study Design: Physico-chemical investigations, Physical characteristics, Qualitative phytochemical analyses, fluorescence analysis and HPLC analysis. Materials and Methods: The Standardization of polyherbal extract was based on systematic organoleptic evaluation, physico-chemical investigation, physical characteristics, heavy metal analysis, fluorescence analysis, phytochemical screening, total alkaloid content, determination of viscosity, surface tension, density and HPLC analysis were carried out by official method. Results: Organoleptic evaluation resulted that it was yellowish green in colour with characteristic odour, bitter, pungent taste and fine texture. All the applied Physico-chemical parameters like total ash, acid insoluble, water soluble ash, extractive values, observed pH, moisture content, crude fibre, foaming index were found to be within limit. The limits obtained from physical and other parameters could be used as reference in quality control. The phytochemical analysis indicated the presence of alkaloids, carbohydrates, flavonoids, volatile oils, tannins, saponins, phytosterols and mucilage. Absence of detectable levels of heavy metal confirmed that extract was non-toxic in nature. HPLC studies confirm the presence of marker compounds in each extract. Conclusion: On the basis of observations and experimental results, the study can be used as reference standard for the further quality control research as it significantly ensures the use of genuine and uniform material and well-designed methodologies for standardization and development of poly herbal extract.

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“…Extracts of Berberis plants have shown interesting results in in vivo models. The ethanolic extract of B. aristata showed antidiabetic activity due to its significant dose-dependent reduction effect on the blood glucose levels (Semwal et al, 2008;Mittal et al, 2012), which were also reported to be better than glibenclamide (Rameshwar et al, 2009) and comparable to metformin in diabetic rats (Pareek and Suthar, 2010). In addition, the aqueous extract of B. aristata showed significant antidiabetic activity, decreased total cholesterol, increased HDL-C levels, and prevented the body weight loss in diabetic rats (Ahamad et al, 2012).…”

Section: In Vivo Activities Against Diabetes and Metabolic Diseasesmentioning

confidence: 99%