Phytochemical composition, antioxidant activity and cytotoxicity of Blumea lacera Linn. from two different habitats

Abstract

Blumea lacera collected from JU campus and the Sundarbans showed strong presence of carbohydrates, flavonoids, trace amount of alkaloids, weak presence of some glucosides, terpenoids and steroids following preliminary phytochemical screening. DPPH free radical scavenging activity increased with the increase of concentration of methanol, ethyl acetate and n-hexane fractions of both the samples. Methanol and ethyl acetate fractions of JU sample showed strong scavenging activity of DPPH free radical. Concentration dependent increment in percent mortality of brine shrimp nauplii was observed in all the fractions of both the samples. Ethyl acetate and methanol fractions of JU sample showed less cytotoxicity than that of Sundarbans samples. Therefore, methanol and ethyl acetate fractions of JU sample should be the choice to identify new bioactive compound(s) in the future.

Blumea lacera (Burm.f.) DC: A review on ethnobotany, phytochemistry, ancient medicinal and pharmacological Uses

“…In a study, three fractions of aerial components of B. lacera, namely n-hexane, methanol and ethyl acetate, exhibited a concentration-dependent increase in the % of death observed in Brine Shrimp nauplii. The LC50 values for mortality in the 3 fractions were reported and these values were higher than those achieved with vincristine sulfate, indicating a cytotoxic impact (82).…”

Analysis of Phytoconstituents, Antioxidant and Anti-bacterial Properties of an Ethnobotanical Herb Cotula anthemoides L. Occurring in Purulia District of West Bengal, India

“…[11] Due to the presence of these pytochemicals some plants of this family such as Ageratum conyzoides, Anaphalis neegerriana and Blumea lacera shows antioxidant, anti-bacterial, antimalarial, antiparasitic, anti-inflammatory and antiviral properties. [12,13] Phytochemical analysis of roots and aerial parts give a piece of information that plant contains important secondary metabolites and exhibits anti-bacterial property against S. aureus and E. coli. AP contain higher amount of total flavonoid and phenolic contents in comparison to RT and also similarly shows higher free radical scavenging property in AP.…”

Chemico-Biological Profiling of Blumea lacera (Burm.f.) DC. (Family: Asteraceae) Provides New Insights as a Potential Source of Antioxidant, Cytotoxic, Antimicrobial, and Antidiarrheal Agents

“…ey play a vital role in the human body to reduce oxidative stress and the destructive effects of ROS [40]. Multiple reports say that plant phenolics are the most significant group of secondary metabolites that play a role as primary antioxidants or free radical scavengers and flavonoids and tannins are the phenolic compounds [41]. e existence of flavonoids and tannins in B. lacera is accountable for the free radical scavenging effects.…”

“…e cytotoxic activities of BLP (LC 50 1.03) compared to vincristine sulfate (LC 50 0.93) may occur due to the presence of diterpene, alkaloid, and steroids [41]. Bacteria have a genetic tendency to develop resistance [43].…”