Phytochemical Constituents and In vitro Pharmacological Response of <i>Cnidium monnieri;</i> A Natural Ancient Medicinal Herb

Munir, Naveed; Mehmood, Zahid; Shahid, Muhammad; Aslam, Samina; Abbas, Mazhar; Mehboob, Huma; Al-Mijallia, Samiah H.; Jahangeer, Muhammad; Badar, Qurrat ul ain

doi:10.1177/15593258221115543

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…Cnidium monnieri (L.) Cuss, an annual plant in the umbelliferous family, is widely used as a traditional herb in China, Japan and Vietnam to treat various diseases. It has a wide range of pharmacological activities, the main component being osthole, which has an allergy-inhibiting (antipruritic) effect on the skin, as well as bacterial, fungal and viral inhibition ( Munir et al, 2022 ). According to modern research, the mechanism of treating T. rubrum is that the water extract from C. monnieri can destroy the mycelial morphology and internal structure of T. rubrum and inhibit its growth ( Yanyun et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using Cnidium monnieri fruit extract

Ye,

Yang,

Zhang

et al. 2023

Front. Microbiol.

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The present study describes a novel method for green synthesis of silver nanoparticles using Cnidium monnieri (CM-AgNPs). Cnidium monnieri fruit is an excellent anti tinea drug that can be used externally to treat superficial fungal infections in the human body. The aqueous ethanolic extract of Cnidium monnieri fruit was prepared and employed in the synthesis of stable silver nanoparticles via biological reduction method. The synthesis conditions of CM-AgNPs was systematically optimized using Box–Behnken design. CM-AgNPs were well characterized by UV-spectroscopy and X-ray powder diffraction (XRD), and it was confirmed that the synthesized particles were AgNPs. The possible functional groups required for the reduction and stabilization of CM-AgNPs in the extract were identified through FTIR spectrum. The size of CM-AgNPs structure was confirmed to be approximately 44.6 nm in polydisperse spherical shape through scanning electron microscopy (SEM), transmission electron microscopy (TEM), and laser dynamic light scattering (DLS). Further, the minimum inhibitory concentration 90% (MIC90) ratios values of Cm-AgNPs against Trichophyton rubrum (7 d), T. mentagrophytes (7 d) and Candida albicans (24 h) were 3.125, 3.125, and 0.78125 μg/mL, respectively, determined by the broth micro dilution method. Finally, the result was concluded that the synthesized AgNPs could be further evaluated in large scale as a potential human topical antifungal agent.

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Section: Introductionmentioning

confidence: 99%

Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using Cnidium monnieri fruit extract

Ye,

Yang,

Zhang

et al. 2023

Front. Microbiol.

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Osthole-infused polyurethane flexible coatings for enhanced underwater drag reduction and robust anti-biofouling

Qin,

Wang,

Fan

et al. 2024

Progress in Organic Coatings

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Extract of Sophorae Flavescentis Radix–Cnidii Fructus Couplet Medicines Treats Vulvovaginal Candidiasis by Affecting the Vaginal Mucosal Barrier

Zhang,

Wang

et al. 2023

Future Microbiol.

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Aim: This study investigated the inhibition of extract of Sophorae flavescentis radix–Cnidii fructus couplet medicines (ESCC) on Candida albicans ( C. albicans) in vitro and the effect of ESCC on the vaginal mucosal barrier in vivo. Materials & methods: Susceptibility testing was performed with C. albicans SC5314. A vulvovaginal candidiasis mouse model was successfully established. The plate method, Gram staining, hematoxylin and eosin staining and ELISA were used to detect relevant inflammatory indexes: IFN-γ, IL-1 and TNF-α. Quantitative real-time PCR and western blot were used to detect mucosal immune-related factors: MUC1, MUC4, DEFB1 and DEFB2. Results: ESCC was able to inhibit the proliferative activity of C. albicans, and it affected inflammation-related factors and indicators of vaginal mucosal immunity. Conclusion: ESCC showed potential value in the treatment of vulvovaginal candidiasis.

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Phytochemical Constituents and In vitro Pharmacological Response of Cnidium monnieri; A Natural Ancient Medicinal Herb

Cited by 3 publications

References 21 publications

Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using Cnidium monnieri fruit extract

Biosynthesis, characterization, and antifungal activity of plant-mediated silver nanoparticles using Cnidium monnieri fruit extract

Osthole-infused polyurethane flexible coatings for enhanced underwater drag reduction and robust anti-biofouling

Extract of Sophorae Flavescentis Radix–Cnidii Fructus Couplet Medicines Treats Vulvovaginal Candidiasis by Affecting the Vaginal Mucosal Barrier

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