Phytochemical constituents, antioxidant activity and antimicrobial potential of Pulicaria incisa (lam.) DC as a folk medicinal plant

Abstract

A B S T R A C TThe species belonging to the genus Pulicaria are well known for their traditional uses in folklore medicine, active chemical constituents and pharmacological activities. Therefore, this study aimed to determine the active constituents, antioxidant activity and antimicrobial potential of Pulicaria incisa (lam.) DC extracts. Ethyl acetate and diethyl ether extracts of the dried aerial parts of P. incisa were prepared. The active secondary constituents (alkaloids, phenolics, flavonoids and tannins) were quantitatively determined. The active constituents in the ethyl acetate extract were higher than those of diethyl ether extract. The ethyl acetate extract expressed higher antioxidant activity in terms of diphenyl picryl hydrazyl (DPPH • ) radical scavenging assay in comparison with ascorbic acid as a reference standard. The antimicrobial activity analysis revealed that the ethyl acetate extract expressed antimicrobial activity against Staphylococcus aureus, Staphylococcus epidermidis, Erwinia carotovora and Candida albicans while that of diethyl ether expressed activity against Bacillus subtillis, Erwinia carotovora and Candida albicans. In conclusion the antioxidant and anti-microbial activity of the studied extracts of P. incisa may be attributed to its richness with the medicinally active metabolites.

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“…Tannic acid was employed as the reference molecule at a concentration of 20 g/mL. The antioxidant activity of complexes and ligands was measured as a decline in DPPH methanolic solution absorbance induced by the impact of each complex or ligand's activity to donate hydrogen, allowing the reduced form of the DPPH radical (pale yellow solution) to emerge [27][28][29][30][31][32][33][34][35]. Metallic compounds have the antioxidant activity in studies due to the metal moiety, which improves their activity as a result, organotin compounds are predicted to have antioxidant activity due to the presence of the metal moiety [36,37].…”

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