Phytochemical constituents of some Nigerian medicinal plants

Edeoga, H. O.; Okwu, Donatus Ebere; Mbaebie, B. O.

doi:10.5897/ajb2005.000-3127

Cited by 1,856 publications

(1,462 citation statements)

References 5 publications

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“…Phytochemical screening was performed with and Edeoga et al (2005). Screening was performed for the following organic compounds: tannins, saponins, terpenoids, flavonoids, cardiac glycosides, phenolic compounds, steroids and alkaloids.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Apoptosis-Inducing Activity of HPLC Fraction from Voacanga globosa (Blanco) Merr. on the Human Colon Carcinoma Cell Line, HCT116

Acebedo

Amor²,

Jacinto³

2014

Asian Pacific Journal of Cancer Prevention

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likely to produce anti-cancer compounds. Using MTT assay, the study aimed to test HPLC fractions from the V globosa leaf extract for cytotoxicity against the HCT116 human colon carcinoma, A549 human lung carcinoma and the non-cancer AA8 Chinese hamster ovarian cell lines. Possible pro-apoptotic activity was also assessed using DAPI nuclear staining, TUNEL assay and the JC-1 mitochondrial membrane potential assay. Production of the ethanolic crude extractMature leaves from V globosa (Blanco) Merr. wereInstitute of Biology, University of the Philippines Diliman (a voucher specimen sample submitted was assigned the accession number: 14609). Leaves were air dried until crispy and then macerated in 95% technical grade ethanol

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Section: Phytochemical Screeningmentioning

confidence: 99%

Apoptosis-Inducing Activity of HPLC Fraction from Voacanga globosa (Blanco) Merr. on the Human Colon Carcinoma Cell Line, HCT116

Acebedo

Amor²,

Jacinto³

2014

Asian Pacific Journal of Cancer Prevention

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“…Concentration of flavonoids, tannins, cyanide, alkaloids and phenols in the extracts were determined by the method described by Harborne (Sukhdev, 2008) and Edeoga et al (2005) …”

Section: Phytochemical Testmentioning

confidence: 99%

Ameliorative effect of methanol extract of Telfairia occidentalis Hook. and Amaranthus hybridus Linn. against cadmium induced oxidative stress in rats

2017

J App Pharm Sci

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Oxidative stress caused by cadmium in living systems leading to various clinical interpretations has been well documented. The study investigated if methanol extract of Telfairia occidentalis and Amaranthus hybridus could ameliorate the toxicity caused by cadmium. Administration of cadmium lead to an increase in lipid peroxidation marker MDA 0.42+018, 1.66+1.13 and reduced the concentration of enzymatic antioxidants SOD 10.22+2.13, 10.92+0.54, Catalase 22.82+14.74, 19.90+1.16 and GSH 18.02+0.49, 12.89+085 in liver and kidney of the rats. Result for liver function assay showed a significant increase in AST 24.00+3.31, ALT 60.40+10.85 and ALP 78.05+15.75 in the serum of rats administered cadmium without treatment. Total protein concentration was significantly higher in the vegetable treated group when compared to the group administered cadmium without treatment 3.72+041. Kidney function assay, creatinine and urea were significantly high in the rat administered cadmium without treatment when compared to the rats that received the vegetables. Phytochemical screening showed the presence of flavonoids, phenols, alkaloid in high concentration in the vegetables. In vitro antioxidant reflected high radical scavenging activity. From the result of this study, the vegetable showed robust ameliorative effect on cadmium induced toxicity which can be labelled to the rich antioxidant content of the vegetables and also the ability of the vegetable to promote phase 2 bio-transformation of xenobiotic.

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“…Phytochemicals are basically divided into two groups that are primary and secondary metabolites according to their functions in plant metabolism. Primary metabolites comprise common sugars, amino acids, proteins and chlorophyll while secondary metabolites consist of alkaloids, flavonoids, tannins, and saponins etc 5,6 .…”

Section: Introductionmentioning

confidence: 99%

Pharmacognostical and Phytochemical studies of Phyllanthus amarus leaves

Dhongade¹,

Chandewar²

2013

Int J of Biomed & Adv Res

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The aim of present work was to investigate the pharmacognostical and phytochemical properties of Phyllanthus amarus leaves. The Ethno medicine involves the use of different plant extracts or the bioactive constituents of vital importance in the health application at an affordable cost and study of such ethanomedicine keenly represents one of the best avenues in searching new economic plants for medicine. Keeping this view in mind the present investigation was carried in Phyllanthus amarus leaves. Morphological study and pharmacognostical properties like transverse section, palisade ratio, stomatal number, stomatal index, vein islet number, and vein termination number were studied. Physical constants like ash value, extractive value, moisture content, swelling index was also studied. Qualitative phytochemical analysis of the plants confirms the presence of various phytochemicals like carbohydrates, alkaloids, glycosides, steroids, saponins, tannins, phenols and flavanoids.

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Phytochemical constituents of some Nigerian medicinal plants

Cited by 1,856 publications

References 5 publications

Apoptosis-Inducing Activity of HPLC Fraction from Voacanga globosa (Blanco) Merr. on the Human Colon Carcinoma Cell Line, HCT116

Apoptosis-Inducing Activity of HPLC Fraction from Voacanga globosa (Blanco) Merr. on the Human Colon Carcinoma Cell Line, HCT116

Ameliorative effect of methanol extract of Telfairia occidentalis Hook. and Amaranthus hybridus Linn. against cadmium induced oxidative stress in rats

Pharmacognostical and Phytochemical studies of Phyllanthus amarus leaves

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