Phytochemical evaluation and in vitro antioxidant and photo-protective capacity of Calendula officinalis L. leaves

Deuschle, Viviane Cecília Kessler Nunes; Deuschle, Regis Augusto Norbert; Piana, Mariana; Boligon, Aline Augusti; Bortoluzzi, Mariana Rocha; Prá, Valéria Dal; Dolwisch, C.B.; Lima, Fernanda O.; Carvalho, Leandro Machado de; Athayde, Margareth Linde

doi:10.1590/1983-084x/14_055

Cited by 10 publications

(5 citation statements)

References 28 publications

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“…Among the 9 plants in a study conducted by Nunes et al (2018), ethanolic extracts of leaves of L. microphylla showed the highest SPF value of 26.82, and S. galheirensis has the lowest SPF value of 5.40 28 . The aqueous ethanolic extract of C. officinalis L. showed low SPF values of 1.89 29 . Yasmeen and Gupta (2016) reported the methanolic barks, leaves, and fruit extracts of D .…”

Section: Resultsmentioning

confidence: 99%

“…Deuschle (2015) found alkaloids, terpenoids, saponins, and volatile oils using thin‐layer chromatography, subsequently, they identified 25 mg/g of rutin and 6.09 mg/g of quercetin in the leaves of C. officinalis L. 29 . Raquel et al (2017) identify apigenin, catchehin, epicatechin, and gallic acid in the barks of S. brasiliensis by comparing the retention time of peaks analytical standards using HPLC–DAD analysis 32 .…”

Section: Resultsmentioning

confidence: 99%

“…Deuschle (2015) found alkaloids, terpenoids, saponins, and volatile oils using thin-layer chromatography, subsequently, they identified 25 mg/g of rutin and 6.09 mg/g of quercetin in the leaves of C. officinalis L.. 29 Raquel et al (2017) identify apigenin, catchehin, epicatechin, and gallic acid in the barks of S.brasiliensis by comparing the retention time of peaks analytical standards using HPLC-DAD analysis. 32 Gasparrini (2015) found myricetin-3-glucoside and myricetin-3-rhamnoside, as well as rutin and cyanidin-3-rutinoside, using HPLC-DAD-IT coupled with a MS. 33 Choi and co-researchers (2019), in a UPHLC study, compounds such as (i) phenolics (pcoumaric acid, caffeic acid, and chlorogenic acid), (ii) polyols (quinic acid and citric acid), and (iii) flavonoids and flavonoid derivatives (patuletin, catechin, epicatechin, eriodictyol, naringenin, quercetin, and quercetin derivatives) were detected in the leaves of P.villosa.…”

Section: Instrumentation In the Identification Of Bioactive Compoundsmentioning

confidence: 99%

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Plant polyphenols as green sunscreen ingredients: A systematic review

Suk

Gew

2022

J of Cosmetic Dermatology

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The sun is the source of energy for living things on Earth. It emits electromagnetic radiation of various wavelengths including infrared, visible, and ultraviolet light. Ultraviolet radiation (UVR) is divided into three regions: UVA, UVB, and UVC. UVA region (320-400 nm) penetrates deep into the skin through the epidermis and dermis, which are responsible for skin darkening, photoaging, and DNA damage. UVB region (280-320 nm) acts mainly on the epidermis, which is the major cause of sunburn and skin cancer. The UVC region (200-280 nm) is less hazardous because the radiation is filtered by the stratospheric ozone layer. 1,2 Excessive exposure to UVR has harmful effects on human skin which potentially causes skin damage. Therefore, photoprotection from both UVA and UVB radiation is more of a concern for the development of sunscreen.Sunscreen plays a critical role in reducing the incidence of UVinduced skin problems with its ability to absorb, scatter, and reflect the harmful radiation, thus creating a chemical barrier on the skin that avoids skin damage caused by UVR. 3 The common ingredients in current sunscreen include organic compounds such as benzophenones, avobenzone, and p-aminobenzoic acid derivatives; inorganic compounds such as zinc oxide, magnesium oxide, titanium dioxide, and kaolin. 4 The long-term use of sunscreen consisting of these ingredients has been reported to cause negative health effects such as dermatitis, phototoxic, photoallergic, photogenotoxicity, and systemic toxicity. [5][6][7] Some studies also reported the negative environmental effect of chemical ingredients in sunscreen such as the damage to coral reefs that leads to ecosystem disruption. 8 Therefore, it is important to develop an effective sunscreen with minimum side effects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Instrumentation In the Identification Of Bioactive Compoundsmentioning

confidence: 99%

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Plant polyphenols as green sunscreen ingredients: A systematic review

Suk

Gew

2022

J of Cosmetic Dermatology

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“…This activity may have been caused by the plant's identification of flavonoids (24.67 mg/g), polyphenols (33.90 mg/g), condensed tannins (27.30 mg/g), rutin (37.25 mg/g), and quercetin (6.09 mg/g) in the study. 98 Using DPPH free radical, hydroxyl radical, and lipid peroxyl radical as indicators of effects, Cetkovic et al investigated the effects of methanolic and water extracts from growing wild marigold (GWM), Calendula arvensis L., and cultivated marigold at concentrations ranging from 0.10 to 0.90 mg/ml. Cultivated marigold extracts demonstrated stronger antioxidant and scavenging activity than GWM extracts; water extracts performed better than methanolic extracts.…”

Section: Antioxidant Effectsmentioning

confidence: 99%

A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Calendula officinalis Linn

Sapkota,

Kunwar

2024

Natural Product Communications

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Calendula officinalis Linn, known as pot marigold, is a plant that belongs to the Asteraceae family. Various online bibliographic databases namely, Google scholar, PubMed, SciFinder, and Web of Science were used for integrating information. Calendula officinalis is extensively used in Homoeopathic, Unani, and Ayurvedic system of medication as diaphoretic, analgesic, antiseptic, and anti-inflammatory agents and used to treat gynaecological issues, gastro-intestinal disorders, inflammations of oral and pharyangeal mucosa, eye problems, skin injuries and certain burns, poor eyesight, and menstrual irregularities. Several studies have shown that Calendula officinalis is a major source of diverse classes of bioactive compounds namely terpenoids, flavonoids, coumarines, quinones, and carotenoids. Various in vivo and in vitro assessment of Calendula officinalis's pharmacological activity suggest that the plant has antidiabetic, anti-inflammatory, anti-tumor, anticancer, and gastroprotective activity. This review compiles the information about pharmacological activities, traditional medicinal uses, and phytochemicals present in Calendula officinalis.

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“…Evaluation of phenolic compounds in Calendula plants is an important task, as indicated by the known HPLC protocols found in the scientific literature. To separate target compounds, only RP C18 columns with varying lengths were used, such as 75 mm ProntoSIL-120-5-C18 [ 90 , 114 , 144 ]; 100 mm Phenomenex C18 [ 142 ], Zorbax SB-C18 [ 143 ], and LiChrosorb RP18 [ 100 , 153 ]; 150 mm Luna C18 [ 131 ], SiliaChrom C-18 [ 140 ], Eclipse XDB-C18 [ 146 ], Spherisorb S3 ODS-2 C18 [ 149 ], Zorbax Eclipse Plus C18 [ 151 ], and Aquity UPLC HSS T3 [ 154 ]; 220 mm Aquapore RP-300 [ 152 ]; 250 mm Shim-pack C-18 [ 96 ], Hypersil C18 [ 141 , 147 ], X-Bridge C18 [ 145 ], and Phenomenex C18 [ 148 ]; 300 mm Bondclone C18 [ 133 ]; and 1000 mm Hypersil Gold [ 75 ]. The presence of various eluents requires the frequent use of formic acid [ 75 , 96 , 142 , 150 , 151 ], acetic acid [ 133 , 141 , 148 ], phosphoric acid [ 140 , 146 ] as the polar eluent and methanol [ 133 , 140 ] and acetonitrile [ 96 , 114 , 141 , 142 ] as the non-polar eluent.…”

Section: Separation Of Calendula Metabolites By Gc...mentioning

confidence: 99%

Marigold Metabolites: Diversity and Separation Methods of Calendula Genus Phytochemicals from 1891 to 2022

Оленников

Кащенко

2022

Molecules

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Marigold (Calendula), an important asteraceous genus, has a history of many centuries of therapeutic use in traditional and officinal medicines all over the world. The scientific study of Calendula metabolites was initiated at the end of the 18th century and has been successfully performed for more than a century. The result is an investigation of five species (i.e., C. officinalis, C. arvensis, C. suffruticosa, C. stellata, and C. tripterocarpa) and the discovery of 656 metabolites (i.e., mono-, sesqui-, di-, and triterpenes, phenols, coumarins, hydroxycinnamates, flavonoids, fatty acids, carbohydrates, etc.), which are discussed in this review. The identified compounds were analyzed by various separation techniques as gas chromatography and liquid chromatography which are summarized here. Thus, the genus Calendula is still a high-demand plant-based medicine and a valuable bioactive agent, and research on it will continue for a long time.

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Phytochemical evaluation and in vitro antioxidant and photo-protective capacity of Calendula officinalis L. leaves

Cited by 10 publications

References 28 publications

Plant polyphenols as green sunscreen ingredients: A systematic review

Plant polyphenols as green sunscreen ingredients: A systematic review

A Review on Traditional Uses, Phytochemistry and Pharmacological Activities of Calendula officinalis Linn

Marigold Metabolites: Diversity and Separation Methods of Calendula Genus Phytochemicals from 1891 to 2022

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