Phytochemical Features of Moringa oleifera Leaves as Anticancer

Edwinanto, Ludovicus; Septiadi, Endry; Nurfazriah, Latifah Rahman; Anastasya, Karina S.; Pranata, Natallia

doi:10.28932/jmh.v2i1.745

Cited by 7 publications

(6 citation statements)

References 2 publications

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“…cytotoxicity based on DNA damage leading to an apoptosis, inhibition of angiogenesis, and interactions with topoisomerase (Carocho & Ferreira, 2013). Edwinanto et al (2018) indicated that the flavonoids (quercetin, kaempferol and myricetin) found in Moringa leaves can induce apoptosis through intrinsic pathways by inhibition of mitogenactivated protein kinase (MAPK), extracellular-signal-regulated kinase 1/2 (ERK 1/2), c-Jun N-terminal protein kinase 1 (JNK), and protein kinase C (PKC). Other authors (Tiloke et al, 2013) found Moringa leaves to be a potential source of antitumor agents, especially due to the presence of niaziminin, a thiocarbamate, that exhibits inhibition of tumor-promoter induced Epstein-Barr virus activation.…”

Section: Bioactive Properties Evaluationmentioning

confidence: 99%

“…Phytochemicals have been isolated from different parts of M. oleifera, such as zeatin, quercetin, sitosterol, caffeoylquinic acid, kaempferol, tannins, terpenoids, saponins, anthraquinones, and alkaloids (Nouman, Anwar, Gull, Newton, & Rosa, 2016;Upadhyay, Yadav, Mishra, Sharma, & Purohit, 2015). Anti-cancerous agents, like glucosinolates, isothiocyanates, glycoside compounds, and glycerol-1-9-octadecanoate have been reported to exercise an effective action on cancer cell lines, during the different stages of cancer evolution (Edwinanto, Septiadi, Nurfazriah, Anastasya, & Pranata, 2018;Tiloke, Phulukdaree, & Chuturgoon, 2013). Leaves of M. oleifera have a low caloric value and can be used in a healthy diet.…”

Section: Introductionmentioning

confidence: 99%

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Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Ziani

Rached

Bachari

et al. 2019

Journal of Functional Foods

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Edible Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck are largely used in the Algerian Sahara. In this context, soluble sugars, fatty acids, organic acids, and tocopherols were characterized. Decoctions and hydroethanolic extracts were studied regarding their phenolic compounds by HPLC-DAD-ESI/MSn, and invitro cytotoxic, anti-inflammatory, and antibacterial activities were evaluated. Results indicate high contents of carbohydrates (glucose and sucrose) and significant levels of protein and mineral were recorded for both plants. Malic acid was the major organic acid alongside with α-tocopherol, while PUFA was predominant in M. oleifera and MUFA in A. leucotrichus. Flavonoid derivatives were the most abundant group, being luteolin-O-(malonylglucoside) the main compound in A. leucotrichus and quercetin-3-O-(6″-malonyl-glucoside) and 3-O-caffeoylquininc acid the major molecules in M. oleifera. Extracts exhibited significant cytotoxicity on Hela and MCF-7 cell lines. The anti-inflammatory activity was also higher in the hydroethanolic extracts, which also revealed the highest antibacterial effects, especially for Gram-positive bacteria. leucotrichus Coss. & Dur. (Apiaceae) is an endemic plant in North Africa and is widely used in traditional medicine, especially in the southern Algerian Sahara and Tassili regions (Louail et al., 2016). Leaves and seeds of this plant are consumed in the form of infusions and/or decoctions for several therapeutic cases, such as liver and digestive system ailments, gastroenteritis, diabetes, as also for blood pressure and chest pain (Halla, Boucherit, Boucherit-otmani, Zohra, & Rahmani, 2018; Louail et al., 2016). The fruits are often used as a spice during culinary preparation, and leaves are used as a flavoring herbal in teas (Halla et al., 2018; Louail et al., 2016). Nevertheless, most phytochemical and biological studies on A. leucotrichus are related to the volatile compounds from the essential oils (Gherraf et al., 2017; Halla et al., 2018), and few scientific studies have been conducted towards the phenolic compounds and their functional properties. According to a recent study conducted by Halla, Heleno, Costa, Fernandes, Calhelha, Boucherit, Rodrigues, Ferreira, and Barreiro (2018) using colorimetric reactions, flavonoids, condensed and hydrolysable tannins, coumarins, alkaloids, and terpenoids were found in the Algerian A. leucotrichus aqueous extract obtained by decoction and in the hydromethanolic extract. El Haci, Mazari, Gherib, and Atik Bekkara (2018) reported moderate

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Section: Bioactive Properties Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Ziani

Rached

Bachari

et al. 2019

Journal of Functional Foods

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“…Dried Moringa leaf has high nutrient density, which is 7 times of the vitamin C of oranges, 17 times of the calcium of milk, 10 times of the vitamin A of carrots, 9 times of the protein of yogurt, 15 times of the potassium of bananas, and 25 times of the iron of spinach (Koul and Chase 2015). Its antioxidant content is relatively high, especially the one from the flavonoid group (Muhammad et al 2016;Edwinanto et al 2018;Lin et al 2018), even 3 times that of other vegetables (Pakade et al 2013). Together with its content of sterol compounds and other diverse compounds, this plant can serve also as a functional food and a medicinal plant.…”

Section: Introductionmentioning

confidence: 99%

Induction of autotetraploid Moringa plant (Moringa oleifera) using oryzalin

Ridwan

Witjaksono

2020

Biodiversitas

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Abstract. Ridwan, Witjaksono. 2020. Induction of autotetraploid Moringa plant (Moringa oleifera) using oryzalin. Biodiversitas 21: 4086-4093. Moringa (Moringa oleifera Lam.) is a plant with high nutritional content and has been widely used as a vegetable and health food ingredient, but its utilization and productivity have not been optimal. Increasing plant productivity can be done by increasing biomass which can be obtained through increasing plant ploidy. This study aims at obtaining tetraploid Moringa by induction using oryzalin compound. Moringa germinating seeds were soaked in oryzalin water solutions for 1, 3, and 5 days with concentrations of 0 µM (control), 15 µM, 30 µM, 60 µM, and 120 µM with 10 seeds for each treatment. We have recovered two tetraploid Moringa plants and two chimeric plants of diploid and tetraploid genomes. Immersing germinating seeds for 1 day in 15 or 60 µM oryzalin concentration effectively induced autopolyploid in Moringa. Tetraploid plants exhibit typical morphological characteristics of a tetraploid, such as low stomata density, larger stomata size, and larger leaflet size compared to the diploid counterpart. The induced tetraploid plants have significantly increased protein, fat, and calcium content compared to the diploid counterpart emphasizing their values as functional food. This polyploidy induction method can be used to produce Moringa tetraploid lines from various accessions in the attempts of developing and selecting high yielding tetraploid Moringa cultivars.

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“…In addition, drumstick plants also contained various bioactive compounds that have pharmaceutical functions such as tannins, saponins, alkaloids, flavonoids, glycosides, and reducing sugars (Isitua et al 2015). The most common bioactive compounds possessed by drumstick is flavonoid (Lin et al 2018) in the form of quercetin, kaempferol, (Muhammad et al 2016;Lin et al 2018) and myricetin (Edwinanto et al 2018) with a concentration of three times more than other vegetables such as Cabbage (Brassica oleracea), Spinach (Amaranthus gangeticus), Peas (Pisum sativum), Cauliflower (Brassica oleracea var. botrytis), and Broccoli (Brassica oleracea var.…”

Section: Introductionmentioning

confidence: 99%

Drumstick (Moringa oleifera) variation in biomass and total flavonoid content in Indonesia

et al. 2021

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Abstract. Ridwan, Hamim, Suharsono, Hidayati N, Gunawan I. 2021. Drumstick (Moringa oleifera) variation in biomass and total flavonoid content in Indonesia. Biodiversitas 22: 493-500. Utilization of a drumstick (Moringa oleifera Lam.) leaf has recently increased worldwide which consequently cause the increase in global demand. Indonesia, as a tropical country with large area, has a great potential to become a center for drumstick cultivation and leaf production. Drumstick distribution scattered in almost all of the islands of Indonesia has another potential for obtaining superior genotype variabilities. The aim of this study was to select the drumstick accessions from several islands in Indonesia with high leaf biomass production and flavonoid content. This experiment was carried out in the field using ten accessions of drumstick from ten islands in Indonesia, namely Sumatra, Java, Madura, Bali, Lombok, Sumbawa, Sumba, Kalimantan, Sulawesi, and Papua. Drumstick seeds were planted in polybags with a capacity of 10 kg and arranged using a randomized block design with three replications. The parameters observed were plant growth, biomass production, total flavonoid content, and antioxidant activity. The results of this study found that Sumatra accession was the accession which had the highest leaf biomass production in combination with the uppermost total flavonoid content and antioxidant activity compared to others. Sumatra accession is recommended as an excellent accession for cultivation with the aim of producing flavonoids.

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Phytochemical Features of Moringa oleifera Leaves as Anticancer

Abstract: Cancer is a disease that can threaten human life.

Cited by 7 publications

References 2 publications

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Detailed chemical composition and functional properties of Ammodaucus leucotrichus Cross. & Dur. and Moringa oleifera Lamarck

Induction of autotetraploid Moringa plant (Moringa oleifera) using oryzalin

Drumstick (Moringa oleifera) variation in biomass and total flavonoid content in Indonesia

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