Phytochemical investigation and diuretic activity of Cyclea peltata leaf extracts

Abstract

Ayurvedic system of medicine is well known for treating renal problems. A vast number of medicinal plants mentioned in Ayurvedic system of medicine are known to possess diuretic properties. Present study reports the preliminary phytochemical investigation of petroleum ether and ethanolic extracts of Cyclea peltata and their diuretic activity. Preliminary phytochemical screening reveals the presence of phytosterols and alkaloids as major phytoconstituents in petroleum ether extract. The ethanolic extract showed the presence of alkaloids, flavonoids, tannins, diterpenes and saponins. Pharmacological investigation revealed that ethanolic extract of C. peltata leaves possessed significant diuretic activity in a given dose of 200 and 300 mg/kg body weight (Diuretic action 1.7 and 2.6, respectively). Where as petroleum ether extract has shown moderate diuresis at a dose of 300 mg/kg body weight (Diuretic action 1.1). The present study justifies the use of C. peltata in the Ayurvedic system of medicine as a diuretic drug.

Evaluation of the Diuretic Activity of Aqueous and 80% Methanol Extracts of Croton macrostachyus(Euphorbiaceae) Leaves in Saline-Loaded Rats

“…With regard to the patterns of urine output and excretion of electrolytes (K + , Na + , and Cl -), together with the diverse bioactive principles present in the crude aqueous and 80% methanol extracts, it appears that the plant may have mechanisms of action similar to some herbal medications suggested to have a wide range of diuretic mechanisms. 31,32 As such, in addition to the suggested carbonic anhydrase-inhibitory activity, osmosis-like effects and increased glomerular filtration rate might be another mode of action that contributes to the diuretic effect of the plant.…”

Comparative pharmacognostical studies on three different plant sources of Pashanbhed

“…[ 14 15 ] The chloride ion concentration was estimated by titration method. [ 16 ] The diuretic action of tested drug was calculated by using the following formula:[ 17 ]…”

Development and evaluation of antimicrobial herbal formulations containing the methanolic extract of Samadera indica for skin diseases

“…They were noted individually after dosing, at least once during the first 30 minutes, periodically during the first 24 hours, with special attention given during the first four hours, daily, and thereafter for a total of 14 days. [ 14 15 ]…”