Phytochemical investigation of Boscia angustifolia A. Rich. (Capparaceae)

Salem, Maha; Hussein, Sameh R.; El-Sharawy, Reham; Ragab, Eman A.; Dawood, Kamal M.; Negoumy, Sabry I.M. El

doi:10.1016/j.bse.2016.02.024

Cited by 5 publications

(2 citation statements)

References 11 publications

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“…Rich. (Capparaceae) [5] or Tunisian species of genus Capparis (Capparaceae) [6] have been done. Recently, we reported the extraction and structural elucidation of phenolic, lignan compounds, and two new phenolic amides stixilamides A and B from the leaves of Stixis suaveolens (Roxb.).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl₄‐induced toxicity

Tung,

Hai,

Anh

et al. 2021

Vietnam Journal of Chemistry

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A herbal remedy formulation including Stixis suaveolens and Pandanus tonkinensis has been established to treat liver diseases in the North‐West region of Vietnam. This study aimed to provide in vitro as well as in vivo scientific evidences which illustrate the hepatoprotective effect of water extract of the above formulation. As a result, the highest oral dosage of water extract equivalent to 29.6 g/kg did not induce any toxic phenomena. Histopathological study showed that water extract formulation could reverse the damage caused by acetaminophen in mice. The water extract reduced significantly the level of ALT and AST enzyme, MDA, TNF‐α and IFN‐γ concentrations in mice treated with acetaminophen compared with control disease group. Furthermore, one of ten fractions from the formulation (F8) showed the strongest hepatoprotectivity in model of CCl4‐induced toxicity in HepG2 cells. Thus, the water extract formulation could be a potential candidate for the protection of liver from diseases.

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Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl₄‐induced toxicity

Tung,

Hai,

Anh

et al. 2021

Vietnam Journal of Chemistry

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“…Rich. (Capparaceae) [1] or research on phenolic components of Tunisian species of genus Capparis (Capparaceae). [2] Recently, phenolic, lignan compounds, and two new phenolic amides stixilamides A and B were firstly identified from the leaves of Stixis suaveolens (Roxb.).…”

Section: Introductionmentioning

confidence: 99%

Characterization of volatile components from ethyl acetate extract of Stixis suaveolens (Roxb.) by comprehensive two‐dimensional gas chromatography hyphenated with a time‐of‐flight mass spectrometer

Ngo

Thanh

Yến

et al. 2020

Vietnam Journal of Chemistry

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This article established a GC-MS profile for ethylacetate extract of herbal plant Stixis suaveolens (Roxb.) Pierre (Capparaceae). The plant was extracted with ethanol then partitioned by ethyl acetate. The ethyl acetate extract was analyzed using comprehensive two-dimensional gas chromatography coupling with a time-of-flight mass spectrometer (GCxGC/TOF-MS). Most of high intensity compounds in ethyl acetate extract were identified. 48 compounds out of 106 peaks were detected including fatty acids, esters, aldehydes, ketones, alcohols, heterocyclic compounds, etc. Many of them show biological activities in diseases treatment. This result facilitates further studies about herbal plants and development of medicine formulation based on traditional medicine in Vietnam.

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Dereplication of phenolic derivatives of three Erythroxylum species using liquid chromatography coupled with ESI‐MSⁿ and HRESIMS

Dantas

Abreu

Cunha

et al. 2021

Phytochemical Analysis

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Introduction: Given the diversity of secondary metabolites produced by species of the genus Erythroxylum, in addition to the many methods that have already been described in the literature, modern screening and identification methodologies, such as dereplication, represent an efficient and quick strategy compared to the classic techniques linked to natural product research. Objective: The objective of the present study was to determine the phenolic profiles obtained from three species of Erythroxylum (Erythroxylum pauferrense Plowman, Erythroxylum pulchrum A.St.-Hil. and Erythroxylum simonis Plowman) by dereplication using liquid chromatography coupled with ESI-MS n and HRESIMS. Material and Methods: Ethyl acetate and n-butanolic fractions from crude ethanolic extract of Erythroxylum species were analyzed by HPLC-ESI-MS n and HPLC-HRESIMS, in order to identify its corresponding compounds. Experiments were performed in negative ionization mode, and the metabolites were provisionally identified based on deprotonated molecules, molecular formulas, fragmentation patterns and literature data. The corresponding isolated compounds were characterized by 1 H and 13 C NMR spectroscopy.Results: According to the dereplication method, it was possible to establish and compare the phenolic profile of the corresponding species by the assignment of 55 compounds, most of which were first described in these species and among which some were also new to the Erytroxylum genus. Additionally, nine compounds were isolated, including biphenyl-3,3 0 ,4,4 0 -tetraol, where the mass spectral data were not sufficient for their identification, and reported for the first time in the Erythroxylaceae family. Conclusion: This research contributes to the phytochemical knowledge of theErythroxylum genus and demonstrates the importance of the dereplication method regarding the investigation of natural products, enabling accurate identification of the metabolites while avoiding the efforts and material expenses involved in the isolation of known compounds.

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Phytochemical investigation of Boscia angustifolia A. Rich. (Capparaceae)

Cited by 5 publications

References 11 publications

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl₄‐induced toxicity

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl₄‐induced toxicity

Characterization of volatile components from ethyl acetate extract of Stixis suaveolens (Roxb.) by comprehensive two‐dimensional gas chromatography hyphenated with a time‐of‐flight mass spectrometer

Dereplication of phenolic derivatives of three Erythroxylum species using liquid chromatography coupled with ESI‐MSⁿ and HRESIMS

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Phytochemical investigation of Boscia angustifolia A. Rich. (Capparaceae)

Cited by 5 publications

References 11 publications

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl4‐induced toxicity

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl4‐induced toxicity

Characterization of volatile components from ethyl acetate extract of Stixis suaveolens (Roxb.) by comprehensive two‐dimensional gas chromatography hyphenated with a time‐of‐flight mass spectrometer

Dereplication of phenolic derivatives of three Erythroxylum species using liquid chromatography coupled with ESI‐MSn and HRESIMS

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Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl₄‐induced toxicity

Hepatoprotective effect of water extract formulation from Stixis suaveolens and Pandanus tonkinensis against liver injury induced by acetaminophen and in vitroCCl₄‐induced toxicity

Dereplication of phenolic derivatives of three Erythroxylum species using liquid chromatography coupled with ESI‐MSⁿ and HRESIMS