Phytochemical, metabolic profiling and antiparasitic potential from <i>Inga semialata</i> leaves (Fabaceae)

Lima, Nerilson Marques; Marqui, Sara Regina de; Andrade, Teresinha de Jesus Aguiar dos Santos; Silva, Dulce Helena Siqueira

doi:10.1080/14786419.2020.1817918

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…Regarding the analysis of the UV-Vis spectra of Peaks 10 , 11 , 14 , and 16 , it was possible to associate them with previous reports for terpene derivatives [ 24 ]. Likewise, Peaks 13 and 17 were consistent with bibliographical data of epigallocatechin gallate derivatives [ 28 ], and Peak 15 may be associated with vanillic acid derivatives [ 29 , 30 ]. Finally, the absorption bands of Peaks 19 , 20 , and 21 were associated with salicylate derivatives [ 31 ].…”

Section: Resultssupporting

confidence: 79%

“…However, similar studies have been documented for other species of the Inga genus; such is the case for I. edulis , where triterpene compounds including lupeol and stigmasterol, as well as aliphatic compounds, have been identified from extracts of the bark and leaves [ 33 , 34 ]. Likewise, extracts from the bark and leaves of I. laurina have shown the presence of terpenes such as phytol, the aliphatic nonacosane, and esterified aliphatic acids [ 35 ], whereas in a hexanic fraction obtained from the leaves of I. semialata , the main compounds isolated were triterpenes, such as lupeol, α-amyrin, oleanolic acid, and friedelin [ 30 ]. In this report, the presence of esterified aliphatic acids was identified and, as in other species of the Inga genus, the presence of lupeol has been established.…”

Section: Resultsmentioning

confidence: 99%

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Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Gallegos-García

Lobato‐García

González-Cortazar

et al. 2022

Plants

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Several Mesoamerican cultures have used Inga jinicuil as traditional medicine for the treatment of gastrointestinal, inflammatory, and infectious issues. The aims of this contribution were to elucidate the phytochemical profile of the organic extracts from the bark and leaves of I. jinicuil and to assess the anti-inflammatory and antibacterial properties of these extracts. The preliminary chemical profile was determined by HPLC-PDA and GC-MS; the anti-inflammatory activity was evaluated with a mouse ear edema model, whereas the antibacterial activity was screened against several bacteria. The phytochemical profile of both organs (bark and leaves) of I. jinicuil led to the identification of 42 compounds, such as polyphenolic, flavonoids, triterpenes, prenol-type lipids, and aliphatic and non-aliphatic esters. This molecular diversity gave moderate anti-inflammatory activity (67.3 ± 2.0%, dichloromethane bark extract) and excellent antibacterial activity against Pseudomona aeruginosa and methicillin-resistant Sthaphylococcus aureus (MIC values of ˂3.12 and 50 µg/mL, respectively). These results contribute to the chemotaxonomic characterization and the rational use in traditional medicine of Inga jinicuil Schltdl & Cham. ex G. Don.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Gallegos-García

Lobato‐García

González-Cortazar

et al. 2022

Plants

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“…Comparison of the NMR data with those reported in the literature showed close similarity with myricetin 3‐ O ‐α‐L‐rhamnoside ( Figure 1). [31,32,33] …”

Section: Resultsmentioning

confidence: 99%

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Tajuddeen

Swart

Hoppe

et al. 2021

Chemistry & Biodiversity

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Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata found in KwaZulu‐Natal in South Africa was investigated for phytochemical constituents, and for antiplasmodial and cytotoxic effects. The plant leaves were collected from the University of KwaZulu‐Natal (UKZN) arboretum on the Pietermaritzburg Campus, in March 2019. The inhibitory activity against 3D7 Plasmodium falciparum was determined using the parasite lactate dehydrogenase (pLDH) assay and cytotoxicity against HeLa cells was evaluated using the resazurin assay. The bioactive compounds were isolated by chromatographic purification and their structures were established with spectroscopic and spectrometric techniques. The plant leaf extract displayed significant antiplasmodial activity at 50 μg/mL and was also cytotoxic against HeLa cells. Chromatographic purification of the extract led to the isolation of two biflavonoids, four flavonoid glycosides, a steroid glycoside, and a megastigmene derivative. The compounds displayed antiplasmodial and antiproliferative activities at 50 μg/mL but the activity was substantially reduced at 10 μg/mL. The activities and compounds are being reported in O. obovata for the first time.

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“…Flavonoids are example of secondary metabolites with several therapeutic properties viz anticancer, antiviral antioxidant, and anti-inflammatory actions (Swargiary et al, 2016;Tijjani et al, 2018). These plants are used as raw materials for the synthesis of conventional drugs (Lima et al, 2020) in the treatment of diseases including those caused by parasites. A review by Newman and Cragg (2016), explains that large fraction of drugs newly approved within the last 25 years are impressively from plant source.…”

Section: Phytoconstituents Nanoformulation/ Nanotherapeuticsmentioning

confidence: 99%

Nanotherapeutics of phytoconstituents for parasitic diseases: a short review

Tijjani

Abdulkarim

Olatunde

et al. 2022

Gadau J Pure Allied Sci

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The treatment of parasitic diseases is multifaceted. The control methods require a complex interplay involving experts in public health, government policies, education, and medical sciences. Several strategies used in the treatment of parasitic diseases are considered and they are based on the availability, effectiveness, affordability, and acceptability of the used drug. Other measures include effective elimination of vector, and animal reservoirs. Interestingly, new strategies and approaches for the treatment of parasitic diseases involve nanomedical encapsulation of drugs and active compounds. Furthermore, genome, cells, and signal pathways targeting have been used for preventing and treating parasitic diseases. These approaches are used for diagnosis, and treatments of disease and to gain increased understanding of underlying disease mechanisms. Phytocompounds such as flavonoids and others are used in nanotherapeutics for treating parasitic diseases as they prevent oxidation of a liable substrate in a system, among other beneficial properties. Therefore, the present review highlights the use of several phytocompounds in nanotherapeutics to treat diseases caused by parasites.

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Phytochemical, metabolic profiling and antiparasitic potential from Inga semialata leaves (Fabaceae)

Cited by 6 publications

References 28 publications

Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Preliminary Phytochemical Profile and Bioactivity of Inga jinicuil Schltdl & Cham. ex G. Don

Antiplasmodial and Cytotoxic Activities of Extract and Compounds from Ozoroa obovata (Oliv.) R. & A. Fern. var. obovata

Nanotherapeutics of phytoconstituents for parasitic diseases: a short review

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