Phytochemical Profile and Investigation of the Spasmolytic Activity of Hydroalcoholic Extract of Syzygium cumini (L.) Skeels Seeds

Abstract

Aims: Perform the phytochemical analysis and investigate the spasmolytic activity of the hydroalcoholic extract obtained from S. cumini seeds (EHS-SC). Study Design: Qualitative phytochemical analysis and test of the EHS-SC on isolated smooth muscles (aorta, trachea, jejunum and uterus) of rat, to value effect relaxant and/or inhibitor. Place and Duration Methodology: EHS-SC was submitted to phytochemical analysis and changes in color, fluorescence and absence or presence of precipitate were observed. The smooth muscle segments were suspended (tension of 1 g) in glass vats containing specific saline solution, at an appropriate temperature and after stabilization period, was stimulated by a suitable contractile agent to observe the effect of EHS-SC in the phasic and/or tonic component. Original ResearchArticle the CCh to 82.9 ± 10.5; 67.6 ± 6.0 and 10.1 ± 8.3%. Conclusion: Spasmolytic activity may be combined with antimicrobial and antidiarrheal activity according to literature data, where they show that the seeds have the same secondary metabolites, signaling the therapeutic potential for the treatment of colic and/or diarrhea. The upward arrow represents the addition of CCh (carbachol). The down arrows represent the concentrations of nsion); min (minutes); W = washPeer-review history: The peer review history for this paper can be accessed here:

Antidiabetogenic action of jamun syzygium cumini skeels: a review

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“…Due to the presence of monoterpene aldehydes, which block protease action and have a bactericidal impact on oral pathogens, S. cumini has antibacterial properties. The phyto-chemical analysis and investigation of the spasmolytic activity of the hydro alcoholic extract derived from S. cumini seeds were done in a study by Monteiro et al, 2020 [35] . The seeds' spasmolytic, antibacterial, and anti-ant diarrheal properties were combined, demonstrating that they share the same secondary metabolites, indicating their therapeutic potential for the treatment of colic and/or diarrhea.…”

The potential health benefits and food applications of jamun (Syzygium cumini L.), an indigenous fruit of India

“…The anti-microbial activity of jamun fruit was owed to the presence of compound known as monoterpene aldehydes and other bioactive compounds including flavonoids such as quercetin, isorhamnetin and kaempferol have antimicrobial activity which was confirmed by Das et al (2019) in his study. A more recent study of Monteiro et al (2020) proved that the spasmolytic effect of jamun seed extracts which was hypothesised to be mediated by the secondary metabolites present in the extract including steroids, alkaloids, phenols and flavonoids (flavonols, flavones and xanthones).…”