Aims: Perform the phytochemical analysis and investigate the spasmolytic activity of the hydroalcoholic extract obtained from S. cumini seeds (EHS-SC). Study Design: Qualitative phytochemical analysis and test of the EHS-SC on isolated smooth muscles (aorta, trachea, jejunum and uterus) of rat, to value effect relaxant and/or inhibitor. Place and Duration Methodology: EHS-SC was submitted to phytochemical analysis and changes in color, fluorescence and absence or presence of precipitate were observed. The smooth muscle segments were suspended (tension of 1 g) in glass vats containing specific saline solution, at an appropriate temperature and after stabilization period, was stimulated by a suitable contractile agent to observe the effect of EHS-SC in the phasic and/or tonic component. Original ResearchArticle the CCh to 82.9 ± 10.5; 67.6 ± 6.0 and 10.1 ± 8.3%. Conclusion: Spasmolytic activity may be combined with antimicrobial and antidiarrheal activity according to literature data, where they show that the seeds have the same secondary metabolites, signaling the therapeutic potential for the treatment of colic and/or diarrhea. The upward arrow represents the addition of CCh (carbachol). The down arrows represent the concentrations of nsion); min (minutes); W = washPeer-review history: The peer review history for this paper can be accessed here:

Objective: to describe hospitalizations for Ambulatory Care Sensitive Conditions (ACSC) in the municipality of Pinheiro -MA. Methods: a descriptive study whose data source was provided by the Unified Health System Hospital Information System (SIH / SUS) from 2008 to 2018. Results: the rate of ACSC in this municipality was 26.1%, corresponding to 14.104 hospitalizations; the five most common diagnoses were bacterial pneumonia, infectious gastroenteritis, inflammatory disease of female organs, kidney and urinary tract infection, and heart failure; there were 698 deaths from ACSC, representing 50.2% of all deaths from hospitalizations; ACSCs consumed R$7.976.062,43, corresponding to 24.0% of total hospitalization expenses in the municipality. Conclusion: the high occurrence of ACSC in Pinheiro -MA points to the need for further investigations on possible factors that are influencing the high rates of these hospitalizations in the studied region.

O principal objetivo deste trabalho é promover a discussão entre o pensamento ético de Hans Jonas, especificamente sobre o termo “Heurística do Temor” no que concerne a possibilidade para uma ética do cuidado ambiental. O filósofo Hans Jonas sustenta que a sobrevivência humana depende de nossos esforços para cuidar do nosso planeta e do seu futuro. E é esta nova óptica de responsabilidade que deve também guiar a maneira como vemos o meio ambiente, cientes da sua perenidade e reconhecendo que desconhecemos o efeito que as tecnologias de hoje terão amanhã, associar o legado de Hans Jonas, com uma nova perspectiva ambiental, conhecendo novas realidades, e discutir a subjetividade na atualidade é importante para o desenvolvimento de estratégias de equilíbrio sustentável no planeta.

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