Phytochemical Screening and &amp;lt;i&amp;gt;in Vitro&amp;lt;/i&amp;gt; Antimicrobial Activity of &amp;lt;i&amp;gt;Waltheria Indica Linn&amp;lt;/i&amp;gt; Leaf Extracts

Koma, Okwute Simon

doi:10.11648/j.bs.20170305.11

Cited by 8 publications

(4 citation statements)

References 28 publications

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“…Hence, the growth of C. albicans was greatly controlled than Penicillium and Aspergillus. The antimicrobial effect of Pa-AgNPs against C. albicans was strong compared to the crude W.indica leaf extracts reported by Koma et al [17]. The results obtained justi es potent microbicidal activity of Pa-AgNPs that were also relevant with the reported literatures [45][46][47] of AgNPs.…”

Section: Antimicrobial Screening Of Pa-agnpssupporting

confidence: 81%

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Characterization, Antimicrobial and Antioxidant evaluation of biofabricated silver nanoparticles from endophytic Pantoea anthophila

Nirmala

Sridevi

2021

Preprint

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Endophyte mediated nanoparticles fabrication was emerging as a new frontier in nanomedicines that produce high biocompatible and functionalized silver nanoparticles. In this study, silver nanoparticles were successfully biosynthesized from the extracellular extract of endophytic bacterium Pantoea anthophila isolated from the stem of Waltheria indica for the first time. The synthesised nanoparticles were characterized by UV-Visible and Fourier Transform Infra-Red spectroscopy. The structural analysis is done by X-ray diffraction and the stability was studied by dynamic light scattering and particle size analyser. The size and shape were observed by Transmission Electron Microscope, Scanning Electron Microscope and Energy Dispersive X-Ray spectrum. Further, the nanoparticles were evaluated for antimicrobial and antioxidant properties. Synthesized nanoparticle showed a strong absorption band in the UV-Visible range at 410 nm. The average particle size was found to be 16.8 nm with spherical shaped, crystalline nature. Good zones of inhibition at various ranges were detected against a broad range of human pathogenic bacteria and fungi. A strong free radical scavenging activity of silver nanoparticles with IC50 values 30.75, 19.47, 34.59, 41.12, 27.24, 28.16, 36.21 µg/ml was obtained that was comparable to the reference. The study suggests that the silver nanoparticles can be biosynthesised from endophytic P. anthophila metabolites with significant therapeutic potential. With proper validation, the biosynthesised silver nanoparticles can be developed as a promising antiviral and anticancer drug candidate.

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Section: Antimicrobial Screening Of Pa-agnpssupporting

confidence: 81%

“…Waltheria indica, a tropical medicinal plant is used traditionally in the treatment of many human ailments [17][18][19]. Endophytic groups colonizing the parts of W. indica are investigated and identi ed a novel bacterium Pantoea anthophila in the stem region.…”

Section: Introductionmentioning

confidence: 99%

Characterization, Antimicrobial and Antioxidant evaluation of biofabricated silver nanoparticles from endophytic Pantoea anthophila

Nirmala

Sridevi

2021

Preprint

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“…Waltheria indica, a tropical medicinal plant is used traditionally in the treatment of cough, skin diseases, microbial infections and inflammatory diseases [28][29][30]. Endophytes have opened a new direction of exploration in nanoparticle synthesis.…”

Section: Introductionmentioning

confidence: 99%

Characterization, Antimicrobial and Antioxidant Evaluation of Biofabricated Silver Nanoparticles from Endophytic Pantoea anthophila

Nirmala

Sridevi

2021

J Inorg Organomet Polym

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Endophyte mediated nanoparticles fabrication were emerging as a new frontier in nanomedicines that produce high biocompatible and functionalized silver nanoparticles. In this study, silver nanoparticles were successfully biosynthesized from the extracellular extract of endophytic bacterium Pantoea anthophila isolated from the stem of Waltheria indica for the first time. The synthesized nanoparticles showed a strong absorption band at 410 nm in the UV–Visible range. The dynamic light scattering and zeta potential analysis indicated that the average particle size was 16 nm at 5.30 mV. FTIR spectrum displayed the presence of various functional groups at 3423.65, 1633.71, 1022.27, 607.58 cm −1 that stabilised the nanoparticle. X-ray diffraction peaks were conferred to 100, 200, 220 and 311 planes of a face centred cubic structure. TEM and SEM micrograph revealed the spherical-shaped, polycrystalline nature with the presence of elemental silver analysed by EDAX. Selected area electron diffraction also confirms the orientation of silver nanoparticles with X-ray diffraction analysis. Antimicrobial activity against 10 different human pathogenic bacteria and fungi showed a broad spectrum inhibition against both Gram-positive and Gram-negative bacteria. Among the bacterial pathogens, B. Subtilis exhibited low activity compared to other pathogens. C. albicans was greatly controlled than other fungal species. A strong free radical scavenging activity of silver nanoparticles with IC 50 values 31.29 ± 0.73, 19.83 ± 1.57, 35.64 ± 0.94, 42.07 ± 1.30, 29.70 ± 2.26, 29.10 ± 0.82, 36.80 ± 0.63 μg/ml was obtained in different antioxidant assays that were comparable to the reference. The study suggests that the silver nanoparticles can be biosynthesized from endophytic P. anthophila metabolites with significant therapeutic potential. With proper validation, the biosynthesized silver nanoparticles can be developed as a promising antiviral and anticancer drug candidate.

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“…Ethanol extract of Waltheria indica had the ability to inhibit S. aureus, E. faecalis, E. coli [8,16,17], in which the leaf extract was the most active. The aqueous extract was resistant to S. aureus, E. faecalis, E. coli [8,18,19].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial properties of alcohol and water extracts of Waltheria indica (L.) plants collected from Binh Thuan province, Vietnam

Mahaxay¹,

Thanh²,

Vu³

et al. 2022

GSC Biol. and Pharm. Sci.

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This study aimed to investigate the antibacterial ability of Waltheria indica species collected from two communes of Phan Thiet city, Binh Thuan province. Research methods included making ethanol extracts and decoction and investigating their ability to inhibit bacteria through agar well diffusion method and determining the minimum inhibitory concentration (MIC). The results showed that the ethanol extract was resistant to 5 tested strains of bacteria (Bacillus cereus, Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Escherichia coli) with diameters of bacterial inhibition zones ranging from 6.76 to 14.50 mm, in which the resistance to Gram-positive strains was better than Gram-negative strains. The decoction inhibited only 3/5 of the tested bacterial strains (S. aureus, E. faecium, E. coli) with MICs from 125 to 750 mg/mL (dry weight of plant per volume of decoction). The antibacterial activities of extracts from the stems, leaves, and roots of the plants were different. Samples obtained from the 2 sites also showed different antibacterial capacities.

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Phytochemical Screening and <i>in Vitro</i> Antimicrobial Activity of <i>Waltheria Indica Linn</i> Leaf Extracts

Cited by 8 publications

References 28 publications

Characterization, Antimicrobial and Antioxidant evaluation of biofabricated silver nanoparticles from endophytic Pantoea anthophila

Characterization, Antimicrobial and Antioxidant evaluation of biofabricated silver nanoparticles from endophytic Pantoea anthophila

Characterization, Antimicrobial and Antioxidant Evaluation of Biofabricated Silver Nanoparticles from Endophytic Pantoea anthophila

Antibacterial properties of alcohol and water extracts of Waltheria indica (L.) plants collected from Binh Thuan province, Vietnam

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