Phytochemical Screening and Antimicrobial Activity of Bryophyllum pinnatum Extracts

Akacha, Linus Usman; Dikko, Jatau Yuwel; Khan, Muluh Emmanuel; Anyam, J.V.; Igoli, John O.

doi:10.9734/bbj/2016/28905

Cited by 9 publications

(6 citation statements)

References 7 publications

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“…Findings from this study revealed that the qualitative phytochemical screening of the ethanolic leave extract of Bryophyllum pinnatum contain secondary metabolites, this is in agreement with other findings that stated that extract of B. pinnatum contain secondary metabolites which are; alkaloids, tannins, saponins, phenols, and flavonoids [16,17]. Quantitative phytochemical screening revealed high contents of flavonoids, saponin, tannins, phenols and alkaloids this corroborates the findings of Akacha et al [18]. Flavonoids and other important constituents of plant were known as free radical scavengers, capable of preventing oxidative damage and reducing oxidative stress while high terpenoids and saponin could be toxic to cellular component [16].…”

Section: Discussionsupporting

confidence: 92%

In vivo Antidiarrhoeal Activity of Bryophyllum pinnatum Leaf Extract on Castor Oil Induced Diarrhea in Albino Rat

Dada

Ojo

2018

JALSI

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Aims: Diarrhoea is more common in rural area and in low-income countries like Nigeria, where children experience an average three episodes of diarrhoea every year. Bryophyllum pinnatum (Crassulaceae) is a widely used medicinal plant in a traditional system with a wide range of biological activities. Hence, In vivo antidiarrhoeal activity of Bryophyllum pinnatum leaf extract on castor oil induced diarrhoea extracts was evaluated.

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Section: Discussionsupporting

confidence: 92%

In vivo Antidiarrhoeal Activity of Bryophyllum pinnatum Leaf Extract on Castor Oil Induced Diarrhea in Albino Rat

Dada

Ojo

2018

JALSI

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“…Preliminary screening of phytochemicals is an important step for detecting various bioactive secondary metabolites of plants, having a vital role towards beneficial medicinal and physiological activities such as antioxidant, antidiabetic, and anticancer activities [ 24 ]. Our study proclaimed the occurrence of bioactive compounds such as flavonoids, alkaloids, phenols, tannins, and saponins, which are similar to the results of another study for both plants [ 25 , 26 ]. Phenolic compounds display potent antioxidant effects by scavenging free radicals due to the presence of hydroxyl groups.…”

Section: Discussionsupporting

confidence: 87%

Evaluation of Phytochemical, Antioxidant, and Memory-Enhancing Activity of Garuga pinnata Roxb. Bark and Bryophyllum pinnatum (Lam) Oken. Leaves

Bhandari

Gyawali

Aryal

et al. 2021

The Scientific World Journal

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Garugapinnata Roxb. (Burseraceae) is a medium-sized tree widely available all over the tropical regions of Asia. Bryophyllum pinnatum (Lam) Oken. (Crassulaceae) is an indigenous and exotic plant grown in tropical regions. Both plants have been used for their anti-inflammatory, antioxidant, anticancer, wound healing, antidiabetic activities, etc. This investigation was designed to explore the result shown by methanolic extract of Garuga pinnata bark and Bryophyllum pinnatum leaves, on cognitive power and retention of the memory in experimental mice along with quantification of phenolic compounds and DPPH radicals neutralizing capacity. The memory-enhancing activity was determined by the elevated plus-maze method in Scopolamine-induced amnesic mice, using Piracetam as allopathic and Shankhpushpi as ayurvedic standard drugs. Two doses (200 and 400 mg/kg p.o.) of both extracts were administered to mice up to 8 consecutive days; transfer latency of individual group was recorded after 45 minutes and memory of the experienced things was examined after 1 day. DPPH assay method and the Folin–Ciocalteu method were employed to determine antioxidant potency and total phenol amount, respectively. 400 mg/kg of the methanolic B. pinnatum bark extract significantly improved memory and learning of mice with transfer latency (TL) of 32.75 s, which is comparable to that of standard Piracetam (21.78 s) and Shankhpushpi (27.83 s). Greater phenolic content was quantified in B. pinnatum bark extract (156.80 ± 0.33 µg GAE/mg dry extract) as well as the antioxidant potency (69.77% of free radical inhibition at the 100 µg/mL concentration). Our study proclaimed the scientific evidence for the memory-boosting effect of both plants.

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“…Crude extracts from the used solvents were phytochemically evaluated for the presence of anthraquinones, saponins, tannins, steroids, terpenes, reducing sugars, flavonoids and alkaloids using standard scrutiny as reported by [29,30]. Phytochemical screening results showed the presence of saponins, tannins, steroids/sterols, tannins, terpenoids, flavonoids, reducing Sugars, and cardiac glycosides.…”

Section: Screening For Phytochemicalsmentioning

confidence: 99%

Isolation, Characterization, Antimicrobial and Theoretical Investigation of Some Bioactive Compounds Obtained from the Bulbs of Calotropisprocera

Khan,

Elum,

Ijeomah

et al. 2023

J. Nig. Soc. Phys. Sci.

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This study characterizes the bioactive molecules from the bulb of Calotropisprocera and investigates the antimicrobial activities of the crude extracts. Theoretical studies on the two isolated compounds in the crude extract were also accomplished.The bulbs were air dried, pulverized, and subjected to extraction procedures by maceration using 500 mL each of normal-hexane, ethyl acetate and methanol. The crude extracts were further tested onmicroorganisms and phytochemical screening using standard procedures. In addition, the bioactive compounds in the extract were screened against DNA gyrase of two Gram negative bacterial species; Escherichia coli and Salmonella typhiusing Molecular Docking simulation techniques and further subjected to ADMET profiling,using the Swiss ADME online server. The Crude ethyl acetate extract has the highest effective activity against Escherichia coli (MIC 2.5mg / mL and MBC/MFC 5mg / mL), Staphylococcus aureus (MIC 2.5mg/mL), Candida albicans, Salmonella typhiand Candida stellafoidea (MIC 5mg/mL). beta-Amyrin acetate and Taraxasterol are the two phytochemicals in the purified white crystalline fractions and were found to fasten to the active sites of DNA gyrase of the Gram negative bacterial species via hydrophobic and hydrogen bond interactions, with binding activity value of -9.6 kcal/mol and -9.5 kcal/mol, respectively. Also, ADMET investigations of the compounds revealed their sound oral bioavailability and excellent pharmacokinetic and toxicity profiles. The findings of this study could provide a platform for discovering safe and potent antibiotics against pathogenic microbes ravaging our society.

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Phytochemical Screening and Antimicrobial Activity of Bryophyllum pinnatum Extracts

Cited by 9 publications

References 7 publications

In vivo Antidiarrhoeal Activity of Bryophyllum pinnatum Leaf Extract on Castor Oil Induced Diarrhea in Albino Rat

In vivo Antidiarrhoeal Activity of Bryophyllum pinnatum Leaf Extract on Castor Oil Induced Diarrhea in Albino Rat

Evaluation of Phytochemical, Antioxidant, and Memory-Enhancing Activity of Garuga pinnata Roxb. Bark and Bryophyllum pinnatum (Lam) Oken. Leaves

Isolation, Characterization, Antimicrobial and Theoretical Investigation of Some Bioactive Compounds Obtained from the Bulbs of Calotropisprocera

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