Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals

Sandabe, Umar Kyari; Onyeyili, P. A.; Chibuzo, G.A.

doi:10.1016/j.jep.2005.08.025

Cited by 19 publications

(17 citation statements)

References 8 publications

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“…Sandabe et al (2003) showed that the aqueous extract possess a sedative effect and an anti convulsive properties in rats. Simple sugars, tannins, saponins, alkaloids and flavone aglycones have been identified in the plant (Sandabe et al 2006). Extracts obtained from the fruits, leaves, stem bark, and root bark usually administered in the form of infusions, decoctions, tinctures, syrups and lotions have been used in the treatments of wide range of diseases and disorders in various African countries (WHO, 1992).…”

Section: Introductionmentioning

confidence: 99%

The combined effects of aqueous extract of Ficus sycomorus l. (Moraceae) Stem Bark and Nigella sativa l. (Ranunculaceae) seeds on hematological and biochemical parameters in rabbits

Sandabe¹,

Abdurrahaman²,

Goniri³

et al. 2009

Anim. Res. Int.

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The stem bark of Ficus sycomorus and the leaves o N gella sativa were collected; dried and extracted using d stilled water and filter paper, to study the effects of combination of these extracts on hematological and biochemical parameters in rabbits. Twenty rabbits weighing between 1000 and 1,200 g were randomly separated into four groups o five rabbits each. Group A rabbits were injected with Ficus sycomorus (200 mg/kg), group B; N gella sativa (100 mg/kg), group C; combinat on of F. sycomorus (200 mg/kg) and N. sativa (100 mg/kg) while group D rabbits were given distilled water and served as control. Blood (1.2 ml) was collected for analyses of hematological and biochemical parameters using standard methods. Bleeding and clotting times were also measured using ear vein puncture and capillary tube methods respectively. The PCV, Hb and RBC values showed various irregular differences (P < 0.05) due to extracts treatments. The differential leucocytes counts and the biochemical parameters did not show any differences (P > 0.05). The bleeding and clotting times (min.) decreased (P<0.05) due to various extracts treatments compared with non-treated group that was given distilled water. Therefore it was concluded that the extracts either alone or in combination could not affect the peripheral blood adversely and it is non toxic to liver, kidney and muscles as indicated by the biochemical analyses and there was no apparent advantage in combining the two extracts as far as these parameters were concerned. f i i f i i

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Section: Introductionmentioning

confidence: 99%

The combined effects of aqueous extract of Ficus sycomorus l. (Moraceae) Stem Bark and Nigella sativa l. (Ranunculaceae) seeds on hematological and biochemical parameters in rabbits

Sandabe¹,

Abdurrahaman²,

Goniri³

et al. 2009

Anim. Res. Int.

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“…Numerous studies were made on genus Ficus to clarify the phylogenetic relationships and evolution in certain subgenera, sections and lower taxonomic ranks, utilizing data sets from entirely different criteria as macromorphology (Berg and Corner, 2005;Chen and Chen, 2005), micromorphology (Dixon, 2002;Neves et al, 2002;Alejandra and José, 2004;Sonibare et al, 2006), chemotaxonomy (Pistelli et al, 2000;Sharaf et al, 2000;Sandabe et al, 2006;Andrzej et al, 2007), reproductive biology (Douglas et al, 2004;Weiblen, 2004), molecular criteria (Noth et al, 1996;Weiblen, 2000;Anuntalabhochai et al 2008) and chromosome studies (Azizian and Sonboli, 2001). However, the obtained results were different; none of these studies have reached a conclusive result in determining the inter-specific relationships between the taxa of Ficus.…”

Section: Resultsmentioning

confidence: 99%

Pollen Morphology of some Species of Genus Ficus L. (Moraceae) from Egypt

2014

Egypt. J. Bot.

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N THE PRESENT work, the pollen morphological characters were extensively studied in 17 taxa from genus Ficus (Moraceae), based on examination with light and scanning electron microscopy. The studied taxa represent three subgenera (Ficus, Sycomorus and Urostigma), collected from three Egyptian Botanical Gardens (Orman, Ain-Shams and Zoo-garden). The obtained results of fundamental and evolutionary significance were: pollen size (less than 20 µm), pollen shape (circular or elliptic), pollen class (vary from di-to triporate), and the pollen surface sculpture (psilate or finely scabrate). The dendrogram produced from the cluster analysis of the characters of pollen grains have been discussed, and shed light on the relationships, similarities and dissimilarities between the studied taxa. Pollen data only does not support macromorphological evidence for the identification of Ficus species.

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“…26 Many studies 27,28 have shown the presence of tannins, flavonoids and flavonols in the leaves of Ficus sycomorus, which could explain the anti-inflammatory action of the two types of extracts presented here. The presence of alkaloids, 28,29 which are compounds recognised for their action on the central nervous system, could equally explain the morphine-type analgesic effect observed.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory Activities of Total Leaf Extracts of Ficus sycomorus L. (Moraceae) used in Traditional Medicine in the Treatment of Sickle Cell Disease

Ramde-Tiendrebeogo¹,

Ouédraogo²,

Tibiri³

et al. 2015

JYP

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Background: This study has been carried out to evaluate the in vivo anti-inflammatory, analgesic and anti-pyretic effects of an aqueous decoction and ethanol extract (95%) of Ficus sycomorus leaves. Methods: The anti-inflammatory effect was evaluated by the carrageenan-induced mice paw oedema model. The non-morphine type analgesic effect was evaluated trough acetic acid-induced writhing test. The morphine type analgesic activity was tested by mouse tail-flick test. The anti-pyretic activity was tested by induced hyperthermia in mice with brewer's yeast. Data analysis used the one way ANOVA test. Results: The anti-inflammatory effects of the two extracts, at doses of 300 and 500 mg/kg b.w., were dose dependent and comparable to those of the reference controls, indomethacin (1 mg/kg b.w.) and hydrocortisone (10 mg/kg b.w.). At the same dose, the analgesic effect of the ethanol extract on abdominal writhings induced by acetic acid, was comparable to those Lysine acetylsalicylate (LAS, 300 mg/kg b.w) and hydrocortisone (10 mg/kg b.w.) used as controls. As for the morphine type analgesic effects of the two extracts tested at doses of 300 and 500 mg / kg both were significantly higher in comparison with the blank control (p<0.05) and comparable to that of morphine (5 mg/kg b.w.) from the 75 th minute. The antipyretic activity of the extracts at the same doses was comparable to those of the LAS (300 mg/ kg b.w.) and hydrocortisone (10 mg/kg b.w.) from the third hour. Conclusion: The results obtained justify the use of the plant in traditional medicine and show the significance of Ficus sycomorus leaves in the search for new anti-inflammatory molecules in the treatment of sickle cell disease.

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Phytochemical screening and effect of aqueous extract of Ficus sycomorus L. (Moraceae) stembark on muscular activity in laboratory animals

Cited by 19 publications

References 8 publications

The combined effects of aqueous extract of Ficus sycomorus l. (Moraceae) Stem Bark and Nigella sativa l. (Ranunculaceae) seeds on hematological and biochemical parameters in rabbits

The combined effects of aqueous extract of Ficus sycomorus l. (Moraceae) Stem Bark and Nigella sativa l. (Ranunculaceae) seeds on hematological and biochemical parameters in rabbits

Pollen Morphology of some Species of Genus Ficus L. (Moraceae) from Egypt

Anti-inflammatory Activities of Total Leaf Extracts of Ficus sycomorus L. (Moraceae) used in Traditional Medicine in the Treatment of Sickle Cell Disease

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