Phytochemical screening and evaluation of cytotoxic activity of Pandanus fascicularis L. (Fruits)

Jitu, K.M. Rahat Maruf; Debnath, Dipti; Asad, Sharmeen; Das, Rajib

doi:10.15562/phytomedicine.2017.43

Cited by 3 publications

(1 citation statement)

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“…The values found in the crude extract, n-hexane, and CCl4 were 1.905 µg/ml, 1.831 µg/ml, and 1.152µg/ml respectively. A significant LC50 value of the extract was noted 39.06 µg/ml [41] which demonstrates that the extract of C. asiatica shows the potentiality to kill cancer cells [42]. In this study, Comparison with positive control Vincristine signifies that cytotoxicity exhibited methanol extract might have mild antitumor and pesticidal activity.…”

Section: Discussionmentioning

confidence: 63%

Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of <i>Centella asiatica</i>

Hossain¹

2018

PLANT

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This study was conducted to investigate the antiemetic, antimicrobial, antioxidant and cytotoxic activity of methanolic extracts of Centella asiatica. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2,2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. Brine shrimp lethality bioassay is done to determine cytotoxic activity. The anti-emetic activity of Centella asiatica leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 38.4 retches as compared to the 60.4 retches of the control group, thus Chlorpromazine reduced the retches by 36.96%. The chickens treated with leaves extracts inhibited the retches up to 15.67%. The manimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 241.71 µg/ml. while compared to that of the reference standard ascorbic acid. Moreover, the methanolic crude extracts also possess moderate cytotoxic principles potential (LC50 value of 39.06 µg/ml) comparing with that of standard vincristine (0.839 µg/ml).

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Section: Discussionmentioning

confidence: 63%

Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of <i>Centella asiatica</i>

Hossain¹

2018

PLANT

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Cultivation and Utilization of Pandanus odorifer for Industrial Application

Nasim

Sandeep

Nayak

et al. 2021

Sustainable Development and Biodiversity

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Population genetic structure and diversity analysis in economically important Pandanus odorifer (Forssk.) Kuntze accessions employing ISSR and SSR markers

Nasim

Sandeep

Sahoo

et al. 2020

Industrial Crops and Products

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Phytochemical screening and evaluation of cytotoxic activity of Pandanus fascicularis L. (Fruits)

Cited by 3 publications

References 0 publications

Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of <i>Centella asiatica</i>

Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of <i>Centella asiatica</i>

Cultivation and Utilization of Pandanus odorifer for Industrial Application

Population genetic structure and diversity analysis in economically important Pandanus odorifer (Forssk.) Kuntze accessions employing ISSR and SSR markers

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Phytochemical screening and evaluation of cytotoxic activity of Pandanus fascicularis L. (Fruits)

Cited by 3 publications

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Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of &lt;i&gt;Centella asiatica&lt;/i&gt;

Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of &lt;i&gt;Centella asiatica&lt;/i&gt;

Cultivation and Utilization of Pandanus odorifer for Industrial Application

Population genetic structure and diversity analysis in economically important Pandanus odorifer (Forssk.) Kuntze accessions employing ISSR and SSR markers

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Product

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Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of <i>Centella asiatica</i>

Determination of Antiemetic, Antimicrobial, Anti-Radical and Cytotoxic Activity of Methanolic Extracts of <i>Centella asiatica</i>