Phytochemical Screening and Formulation of Hand Sanitizer Gel Preparations from Temu Hitam Rhizome Extract (Curcuma aeruginosa Roxb)

Abstract

Temu Hitam (Curcuma aeruginosa Roxb) is one of the most widely grown plants in Indonesia at an altitude of 400–750 m asl and contains many secondary metabolites, including flavonoids, alkaloids, saponins, tannins, and curcuminoids, which in the test had antibacterial activity and growth inhibitors. worm larvae in the gastrointestinal tract and the effect of increasing the body's immunity The purpose of this study was to identify the content of secondary metabolites contained in the rhizome of black turmeric, which would then be formulated into gel hand sanitizer preparations. Secondary metabolite testing was conducted on alkaloids, flavonoids, saponins, tannins, steroids/triterpenoids, and glycosides. Three different hand sanitizer gel formulations were created using different extract concentrations, 5%, 10%, and 15%. Evaluation tests were then run on the preparations, including stability, organoleptic, homogeneity, pH, and dispersion tests. Alkaloids, flavonoids, tannins, saponins, and steroids were found in the temu hitam rhizome, according to the results of secondary metabolite testing. The dosage form was semi-solid, had a light brown to blackish brown hue, a distinct spice scent, was homogeneously prepared, and had a pH of 7.0, according to the examination of the formulation results 4,1 ± 0,17; 4,4 ± 0,19; 4,9 ± 0,08; 4,9 ± 0,09, viscosity 2378 ± 209,9; 3340 ± 220,7; 4509 ± 285,6; 4881 ± 276,7; and spreadability test 5; 6,2; 5,4; 4,9 cm . The conclusion of this study is that the results of the phytochemical screening of simplicia and the ethanolic extract of the Temu Hitam rhizome showed positive results, containing secondary metabolites of alkaloids, flavonoids, tannins, saponins, glycosides, and steroids/triterpenoids that can be formulated into hand sanitizer gel preparations that meet the requirements for preparation evaluation.

Formulasi dan Evaluasi Sediaan Blush on Stick Ekstrak Umbi Bit (Beta Vulgaris L) Sebagai Antioksidan

“…diamati secara visual untuk mengamati keseragaman lapisan terbentuk, dan lihat apakah ada fragmentasi, atau kerusakan produk selama aplikasi. 20 Daya sebar semipadat dibedakan 2 ragam, yakni semikaku (3-5 cm) serta semicair (5-7 cm). 15 Kelima adalah daya lekat, yaitu pengetesan kemampuan lekat dicoba dengan menimbang 0,5 g blush on stick diletakkan di atas piringan hitam cermin serta ditutup dengan piringan hitam cermin lain.…”

“…Pengujian semua sediaan tidak terdapat butiran kasar yang menandakan bahwa sediaan homogen. 20 PH kulit biasanya asam, berkisar pada nilai pH 4-6, sedangkan lingkungan internal tubuh mempertahankan pH mendekati netral (7)(8)(9). Ini menciptakan gradien pH yang curam 2-3 unit antara subkutan dan epidermis di bawahnya dan dermis.…”