Phytochemical screening and in vivo antipyretic activity of the aqueous extracts of three Moroccan medicinal plants

Hajjaj, Ghizlane; Bahlouli, Aziz; Sayah, Karima; Tajani, Mouna; Cherrah, Yahia; Zellou, Ahmed

doi:10.26510/2394-0859.pbe.2017.30

Cited by 4 publications

(3 citation statements)

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“…The choice of the derivatization technique was made to improve and increase the volatility, sensitivity, thermal stability, greater selectivity, and separation behavior of the analytes [ 30 ]. Another study on aqueous extracts of two Moroccan chamomiles, C. mixtus and M. chamomilla , discovered the presence of alkaloids, terpenoids, saponins, flavonoids, and tannins, but not anthraquinones [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Characterization and Several Bioactivities of Cladanthus mixtus from Morocco

et al. 2023

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The purpose of this work was to investigate, for the first time to our knowledge, the chemical composition and bioactivity of methanolic extracts (roots, stems, leaves, and flowers) from Cladanthus mixtus (L.) Chevall. that grows wild in northern Morocco (the Tangier-Tetouan-Al Hoceima region). The phenolic and flavonoid contents were determined by spectrophotometer methods, and the composition of derivatized methanolic extracts from C. mixtus using N-O-bis(trimethylsilyl) trifluoroacetamide (BSTFA) was analyzed by gas chromatography–mass spectrometry (GC-MS). The antioxidant activity was carried out by applying the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and DPPH (2,2-diphenyl-1-picrylhydrazyl) tests. The micro-dilution technique was chosen to investigate the antimicrobial activity of methanolic extracts against two bacterial strains and three fungal species. The results showed that the values of total phenolic and flavonoid contents were found to be higher in flower extracts (30.55 ± 0.85 mg of gallic acid equivalents (GAE)/g of dried weight (DW) and 26.00 ±1.34 mg of quercetin equivalents (QE)/g DW, respectively). Other groups of chemical compounds were revealed by GC-MS, such as carbohydrates (27.25–64.87%), fatty acids (1.58–9.08%), organic acids (11.81–18.82%), and amino acids (1.26–7.10%). Root and flower methanolic extracts showed the highest antioxidant activity using ABTS (39.49 mg of Trolox equivalents (TE)/g DW) and DPPH (36.23 mg TE/g DW), respectively. A positive correlation between antioxidant activity and polyphenol and flavonoid amounts was found. Antibacterial tests showed that the best activity was presented by the leaf extract against Staphylococcus aureus (minimum inhibitory concentration (MIC) = minimum bactericidal concentration (MBC) = 20 mg/mL) and Escherichia coli (MIC of 30 mg/mL and MBC of 35 mg/mL). S. aureus was more sensitive to the extracts compared to E. coli. All extracts showed antifungal activity against Trichophyton rubrum, with the best efficacy reported by the flower and leaf extracts (MIC = 1.25 mg/mL and minimum fungicidal concentration (MFC) = 2.5 mg/mL). In general, extracts of C. mixtus appeared less effective against Candida albicans and Aspergillus fumigatus.

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Section: Discussionmentioning

confidence: 99%

Chemical Characterization and Several Bioactivities of Cladanthus mixtus from Morocco

et al. 2023

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“…Like the Bedouin populations, Tuareg community constitute the nomadic people of Sahara in Algeria and Libya were reported to collect the fruits of wild pistachios, roasting and consuming them like other nuts (Abdelkrim and Noria, 2014 ;Miara et al, 2019). In Morocco, P. atlantica is important because it is the source of mastic gum, an exudate which strengthens gums, deodorizes breath and combats coughs, chills and stomach diseases (El-Hilaly et al, 2003;Hajjaj et al, 2017). The decoction of P. atlantica leaves is used in Morocco to treat eye infection.…”

Section: Vernacular Names and Traditional Usesmentioning

confidence: 99%

“…Pharmacological property models of the aqueous extract, obtained from aerial parts (Fresh leaves, unripe fruits and leaf-buds) of P. atlantica Desf. of Morocco were investigated in vivo by Hajjaj et al, (2017). In that study the anti-inflammatory activity of the aqueous extract was measured against acute paw edema induced by carrageenan.…”

Section: Anti-inflammatory Analgesic and Antinociceptive Activitiesmentioning

confidence: 99%

Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Ahmed

Yousfi

Viaene

et al. 2021

Journal of Ethnopharmacology

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Quinic and Digallic acids from Pistacia atlantica Desf. Leaves Extracts as Potent Dual Effect Inhibitors against main Protease and RNA-dependent RNA Polymerase of SARS-CoV-2

Benguechoua

Benarous

Benahmed

et al. 2022

CAD

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Background: Through this study, the Chemical composition realized by UHPLC-DAD-ESI-MSn allowed the detection of different phenolic compounds groups from Pistacia atlantica Desf. leaves extracts. We studied the inhibition of main protease (CL3 Mpro) and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2 by the identified molecules through molecular docking. Objective: The objective of this study is to identify compounds from Pistacia atlantica Desf. leaves extracts, which might have anti-viral effects. Methods: Chemical composition realized by UHPLC-DAD-ESI-MSn, the inhibition of main protease (CL3 Mpro) and RNA-dependent RNA polymerase (RdRp) of the SARS-CoV-2 is studied using molecular docking with Autodock Vina software. ADMET analysis was carried out. Results: The identified compounds are quinic acid, digallic acid, galloylquinic acid, gallic acid, trigallic acid, digalloylquinic acids, trigalloylquinic acids and methyl gallate; digallic and quinic acids are the best inhibitors. Digallic acid had binding affinity energy (BAE) of -8.2 kcal/mol, and Ki of 1µM for the CL3 Mpro, Ki of 0.62 mM for the RdRp. Quinic acid showed Ki of 4.6 mM, recorded for both enzymes. Through ADMET analysis, we have found that the two molecules are good drugs candidate. Conclusion: This is the first time that a group of identified compounds from Pistacia atlantica Desf. leaves is studied for their potential activity against the novel virus by inhibiting two key enzymes in its life cycle, and no further studies have been published in this context.

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Phytochemical screening and in vivo antipyretic activity of the aqueous extracts of three Moroccan medicinal plants

Cited by 4 publications

References 3 publications

Chemical Characterization and Several Bioactivities of Cladanthus mixtus from Morocco

Chemical Characterization and Several Bioactivities of Cladanthus mixtus from Morocco

Four Pistacia atlantica subspecies (atlantica, cabulica, kurdica and mutica): A review of their botany, ethnobotany, phytochemistry and pharmacology

Quinic and Digallic acids from Pistacia atlantica Desf. Leaves Extracts as Potent Dual Effect Inhibitors against main Protease and RNA-dependent RNA Polymerase of SARS-CoV-2

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