Phytochemical screening and wound healing activity of Telephium imperati (L.) in rats

Nejjari, Rachid; Benabbes, M; Amrani, M.; Meddah, Bouchra; Bouatia, Mustapha; Taoufik, Jamal

doi:10.1016/j.sajb.2019.03.023

Cited by 16 publications

(5 citation statements)

References 15 publications

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“…These results are supported by the study by Abdul Latif et al (2015) where histological analysis of wounds treated with 3% of Alocasia denudata stem juice showed a large number of fibroblast proliferation and collagen synthesis resulting in increased wound tensile strength and better wound healing effects. Collagen is the primary structural protein of the extracellular matrix produced by fibroblasts, which is crucial for epithelization, tensile resistance, and structural support (Nejjari et al, 2019). The high content of collagen fibres in the granulation tissue of ethanol extract and chloroform fraction indicates the effectiveness of A. longiloba petiole extract.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical screening and wound healing effect of Alocasia longiloba Miq. petiole ethanolic extract and its fractions in excision wound rat model

Nurul Hazirah Che Hamzah,

Arifullah Mohammed,

Kuttulebbai Naina Mohamed Salam Sirajudin

et al. 2022

BIJB

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Alocasia longiloba Miq., or ‘keladi candik’ is traditionally used for wound healing in Malaysia. Preliminary studies have been performed to determine the dose range of A. longiloba for potential wound healing. Therefore, this study continues to determinethe phytochemical screening of fractions and their ability in accelerating wound healing. Ethanol crude extract of A. longiloba and its fractions of hexane, chloroform, and ethyl acetate was prepared and used for phytochemical screening and wound healing formulation. Seven groups of Sprague-Dawley rats (n = 3) were experimentally wounded in the dorsal area for 12 days. Group I was left untreated, Group II was dressed in petroleum jelly as the vehicle group, Group III was treated with Solcoseryl jelly 10% as the positive drug, and the rest of the groups were dressed with respective formulations at 6% concentration. The wound area was photographed and measured, and the histological examinations of granulation tissues were examined. The phytochemical screening of chloroform fraction shows an abundance of alkaloids, flavonoids, and tannins, which are considered responsible for wound healing activity. The chloroform fraction proved more effective, showing a significant percentage of wound contraction (p<0.05) compared to the negative and vehicle control groups. Moreover, histological observation of wounds treated with chloroform fraction of A. longiloba showed an organized epithelial layer, fewer blood vessels, and dense collagen fibres comparable with normal rat skin.

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Section: Discussionmentioning

confidence: 99%

Phytochemical screening and wound healing effect of Alocasia longiloba Miq. petiole ethanolic extract and its fractions in excision wound rat model

Nurul Hazirah Che Hamzah,

Arifullah Mohammed,

Kuttulebbai Naina Mohamed Salam Sirajudin

et al. 2022

BIJB

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“…Despite the variety of plants highlighted in the surveys above, only a few studies on the healing activity of plants have been conducted in Morocco. Nejari et al [ 19 ] and Jawhari et al [ 20 ] studied the wound healing properties of Telephium imperati L. and Anacyclus pyrethrum L, respectively.…”

Section: Introductionmentioning

confidence: 99%

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Mekkaoui

Assaggaf

Qasem

et al. 2021

Foods

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Wound healing consists of several continuous phases involving various cells and chemical intermediates. As a rich source of nutrition elements, honey has proved to have potential benefits in the treatment of various diseases. The present study was designed to investigate the healing effect of a honey mixture with selected essential oils on chemical and thermal wound models in rabbits. Dressing mixtures of Thymus vulgaris honey with three essential oils (Origanum vulgare, Rosmarinus officinalis, and Thymus vulgaris) were prepared and applied daily in the treatment groups. These essential oils were rich in phytochemicals and had significant antibacterial activity against four selected ATCC bacterial strains. Madecasol ointment was used as a standard control. The healing effect of the mixtures was evaluated by measuring wound surface area and comparing healing time. The results showed that the healing rate in the treatment groups was significantly higher than that of the untreated group and standard group. The best healing effect for burns was seen in the mixture of honey and Thymus vulgaris essential oil, which had wound closure rates of 85.21% and 82.14% in thermal- and chemical-induced burns, respectively, and showed the shortest healing time (14 days) in comparison to other groups. Therefore, it can be concluded that honey mixtures have significant beneficial effects on skin wound healing and, thus, they may be used as a healing agent in different types of wounds in humans after specific clinical trials.

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“…Recently, many studies have reported about wound healing, but these have not been at the desired level yet. Several medicinal plants are used in the folk medicine for their wound healing potential such as, Centella asiatica, and Telephium imperati (L.) [5,6]. They are widely favored due to their safety, low cost and easy access [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vivo wound healing activity of Moroccan Citrus reticulata peel extract

et al. 2020

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Background Citrus reticulata is one of the most cultivated fruit with great benefits for humans in the world. Citrus reticulata peel has several biological activities within them hypoglycemic, hepatoprotective, antimicrobial and antioxidant. The present study emphasizes on the in vivo wound healing and in vitro antimicrobial and antioxidant activities of Citrus reticulata peel extract. Methods Forty albino mice (23–29 g) of either sex were divided into four groups. The test groups were treated with experimental ointment (0.5% and 10% of methanolic extract), negative control were treated with Vaseline and the positive control were treated with silver sulfadiazine. Burn wounds were induced on dorsal area of mice bodies. Wound area measurement was carried out every day during 22 days. Biochemical screening was performed to identify possible compounds. Antioxidant and antimicrobial activities were also determined. Results Significant wound healing activity was observed with topical application of Citrus reticulata peel extract. Wound area reduction at day 16 of treatment was 100% for both treated groups (0.5% and 10%) when compared to positive and negative control it was 100% and 98.32% respectively at day 22. Furthermore higher rate of wound contraction (100% on 16th day) was observed for both treated groups. The result of biochemical screening showed that C. reticulata peel is characterized by highest amount of total polyphenols (13.19 mg/g), flavonoids (4.07 mg/g), vitamin C (13.20 mg/g), carotenoids (0.032 mg/g) and lowest content of macronutrients (Proteins: 0.40%, reducing sugars: 7.21%; lipids: 1.5%). Additionally C. reticulata peel exhibited remarkable antioxidant activity using DPPH and phosphomolybdate methods as well as the extract possess antimicrobial effect against pathogen bactria. Conclusion The findings from this research indicated that Citrus reticulata peel extract is effective in inhibiting the growth of pathogen bacteria and could be of therapeutic potentials for wound healing.

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Phytochemical screening and wound healing activity of Telephium imperati (L.) in rats

Cited by 16 publications

References 15 publications

Phytochemical screening and wound healing effect of Alocasia longiloba Miq. petiole ethanolic extract and its fractions in excision wound rat model

Phytochemical screening and wound healing effect of Alocasia longiloba Miq. petiole ethanolic extract and its fractions in excision wound rat model

Ethnopharmacological Survey and Comparative Study of the Healing Activity of Moroccan Thyme Honey and Its Mixture with Selected Essential Oils on Two Types of Wounds on Albino Rabbits

Evaluation of in vivo wound healing activity of Moroccan Citrus reticulata peel extract

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