Phytochemical Screening, Antioxidant and Cytotoxic Activities in Extracts of Different Rhizome Parts From Curcuma Aeruginosa Roxb.

Nurcholis, Waras; Khumaida, Nurul; Syukur, Muhamad; Bintang, Maria; C, Ardyani I D A A

doi:10.7897/2277-4343.065118

Cited by 13 publications

(5 citation statements)

References 9 publications

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“…Several previous findings supported that alkaloids, carbohydrates, flavonoids, glycosides, phenolics, tannins, saponins, terpenoids, and quinones were present in C. longa, C. aeruginosa, C. xanthorrhiza, and C. caesia (Hasan et al 2014;Pakkirisamy et al 2014;Donipati and Hara Sreeramulu 2015;Sawant and Godghate 2015;Waras et al 2015;Oghenejobo 2017;Irshad et al 2018;Joshi et al 2018) that was consistent with our findings in this study. Therefore, we can postulate that the presence of these major phytochemical groups is independent of geographical factors and can be used as chemotaxonomical markers unique to the species.…”

Section: Qualitative Phytochemical Screeningsupporting

confidence: 92%

“…The genus Curcuma has been an essential component of folklore medicine in numerous cultures. It has been reported to be used for the treatment of various disorders such as liver and skin problems and diseases, rheumatism, stomach ache, diarrhea, nausea, gingivitis, motion sickness, hypercholesterolemia, high levels of fatty acids, cancer, hemorrhoids, asthma, inflammation and leprosy (Naksuriya et al 2014;Subositi and Wahyono 2019;Mahadevhi and Kavitha 2020;Walker and Mittal 2020). Among other ethnobotanical applications of Curcuma are condiments, food preservatives, and coloring materials.…”

Section: Introductionmentioning

confidence: 99%

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Phytochemical diversity and biological activities of Curcuma species from the East Coast of Peninsular Malaysia

YURASBE,

DIN,

PALANIVELOO

et al. 2023

Biodiversitas

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Abstract. Yurasbe NQ, Din NA, Palaniveloo K, Manikam S, Nagappan T. 2023. Phytochemical diversity and biological activities of Curcuma species from the East Coast of Peninsular Malaysia. Biodiversitas 24: 4243-4252. Zingiberaceae has been associated with traditional medicine for centuries. The genus Curcuma is traditionally famous and economically important for its therapeutic and nutritional values. Over 50 genera of 1600 species are recorded worldwide, with the highest concentration in the Malesian region, including Indonesia, Borneo, Thailand, Malaysia, Vietnam, Cambodia, Myanmar, and the Philippines. We investigated the methanolic crude extracts of Curcuma aeruginosa, Curcuma caesia, Curcuma longa, Curcuma xanthorrhiza, and Curcuma zedoaria from Terengganu for their phytochemicals, total phenolic content (TPC) using Folin-Ciocalteu colorimetric method, total flavonoid content (TFC) using aluminum chloride colorimetric method, antioxidant activity using the 2,2-diphenyl-1-picryl-hydrezyl (DPPH) radical scavenging activity and toxicity using brine shrimp lethality test (BSLT). Phytochemical screening revealed alkaloids, flavonoids, phenolics, saponins, tannins, triterpenoids, glycosides, lignins, and oils in all species investigated. Curcuma longa extract had the highest phenolic and flavonoid content with the value of 155.31±1.78 mg GAE/g and 151±8.35 mg quercetin/g, respectively as well as best antioxidative potential with IC50 value of 88.65±0.6 mg/mL, followed by C. zedoaria (98.61±5.23 mg/mL), C. aeruginosa (142.51±3.29 mg/mL), C. xanthorrhiza (150.01±0.63 mg/mL) and C. caesia (156.4±0.67 mg/mL). Curcuma caesia displays the lowest degree of toxicity compared to the other species, with the LC50 value of 11585 mg/mL) considered non-cytotoxic. Hence, the selected Curcuma species has potential therapeutic value to be developed into pharmaceutical due to its significant bioactive potentials and potent antioxidant capacity.

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Section: Qualitative Phytochemical Screeningsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Phytochemical diversity and biological activities of Curcuma species from the East Coast of Peninsular Malaysia

YURASBE,

DIN,

PALANIVELOO

et al. 2023

Biodiversitas

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show abstract

“…The rhizome powder was extracted using the maceration technique described in our previous research (Nurcholis et al 2015). Briefly, the sample powder (25 g) were extracted at room temperature with 70% ethanol of 250 ml for 24 h. The solution sample was filtered with the Whatman filter paper of number 4.…”

Section: Plant Materials and Extractionmentioning

confidence: 99%

GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent

et al. 2021

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Abstract. Nurcholis W, Khumaida N, Bintang M, Syukur M. 2021. GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent. Biodiversitas 22: 1179-1186. This work aimed to evaluate the bioactive compounds and anticancer activity in rhizome extract of ten Curcuma aeruginosa accessions to explore their pharmacological values. The GC-MS analysis was used to identify bioactive compounds. The cytotoxic activity was performed against MCF-7 (Human breastadeno carcinoma) and Vero cell lines using MTT assay. The GC-MS analysis revealed 71 of the compounds as sesquiterpenes (36), monoterpenes (20), phenolics (5), diterpenes (4), phenanthrene (1), tetrapeptides (1), oxazole (1), triazine (1), piperidine (1), and oxygenated hydrocarbons (1). The isocurcumenol was the most dominant metabolite in ethanol extract of C. aeruginosa rhizome, with the highest produced by KP accession (22.01%) followed MD accession (21.12%). However, camphor and β-elemene were the metabolites produced by all accessions studied. In the Vero cell line as a normal cell, the cytotoxic activity varied from 13.28% (MD) to 45.17% (PW). Furthermore, the cytotoxic activity ranged from 1.16% (LC) to 49.70% (MD) against the MCF-7 cell line. The highest anticancer activity was produced in MD accessions; thus, it can be used as a source of quality raw materials for the pharmaceutical and food industry. Besides that, it can also be further developed to obtain superior varieties through plant breeding programs.

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“…The methanol extracts were subjected to preliminary phytochemical tests to find out presence of different classes of phytochemicals [7][8][9] .…”

Section: Preliminary Phytochemical Studiesmentioning

confidence: 99%

A Comparative Study on the Antioxidant Activity of Methanol Extracts of Carica Papaya Fruits Prepared by Hot and Cold Maceration Techniques

Seow¹,

Morazuki²,

Dash³

2016

J Biol Sci Opin

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The present study was aimed to evaluate the antioxidant potential of the methanol extracts of Carica papaya fruits using thermal and non thermal methods of extraction. Preliminary phytochemical studies, determination of total phenolic and flavonoid contents and DPPH radical scavenging assay were performed. Preliminary phytochemical screening of the extracts showed presence of alkaloids, flavonoids, tannins and phenolic compounds. The total phenolic and flavonoid contents revealed higher concentration in the extract prepared by cold maceration process than its counterpart, with higher percentage of scavenging DPPH radical. Thus, it may be concluded that application of higher temperature during extraction process affects the phytoconstituents of C. papaya fruits.

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Phytochemical Screening, Antioxidant and Cytotoxic Activities in Extracts of Different Rhizome Parts From Curcuma Aeruginosa Roxb.

Cited by 13 publications

References 9 publications

Phytochemical diversity and biological activities of Curcuma species from the East Coast of Peninsular Malaysia

Phytochemical diversity and biological activities of Curcuma species from the East Coast of Peninsular Malaysia

GC-MS analysis of rhizome ethanol extracts from Curcuma aeruginosa accessions and their efficiency activities as anticancer agent

A Comparative Study on the Antioxidant Activity of Methanol Extracts of Carica Papaya Fruits Prepared by Hot and Cold Maceration Techniques

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