Phytochemical Screening, Antioxidant, Antibacterial, Antifungal Potential and in vivo Acute Toxicity of the Crude Extract of Cordia Rothii and Viola Serpens

Abstract

Background: Plants contain numerous bioactive compounds with valuable pharmacological activities and can be used as a novel therapeutic agent. Methods: The objective of the current study was to evaluate phytochemical screening, antioxidant, antibacterial, antifungal, and acute toxicity capacity of Cordia rothii (CR) and Viola serpens (VS) plant extract. Results: The phytochemical screening revealed the presence of saponins, tannins, anthraquinones, and flavonoids contents. Antioxidant activity of both extracts was measured by total phenolic, total flavonoid content, DPPH, and reducing power capacity. IC50 value of CR and VS extract was calculated as 0.039 ± 0.05, 0.05 ± 0.07 mg/ml respectively. Both extract have antibacterial activity against S. aureus and S. epidermidis, whereas VS is inactive against E. coli. Antifungal activity was not found in both CR and VS extract. The LD50 of the test substance was also estimated to be over 10 g/kg body weight. Conclusions: The conclusion indicates that folkloric uses of both plants in traditional settings, the extracts possess antibacterial activity with remarkable antioxidant ability.