Phytochemical Study of Endemic Species Helleborus Caucasicus, Helleborus Abchasicus and Ficaria Popovii Spread in Southern Colchis

Beridze, Medea; Kalandia, Aleko; Japaridze, Indira; Vanidze, Maia; Varshanidze, Natela; Turmanidze, Nazi; Dolidze, Ketevan; Diasamidze, Inga; Jakeli, Eteri

doi:10.12955/pmp.v1.89

Cited by 2 publications

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“…In recent times, various natural compounds possessing antioxidant and chemopreventive properties have been studied for the treatment and prevention of colon toxicity and cancers. 36 Gallic acid naturally found in figs, tea and berries with antioxidant activities have displayed the potential in the prevention of colon toxicity in Wistar rats. 6 Similarly, Naringenin flavonoid found in citrus fruits has demonstrated chemopreventive efficacy due to antioxidant and anti-inflammatory properties in experimentally induced colon cancer in rats.…”

Section: Discussionmentioning

confidence: 99%

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

et al. 2021

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Colon cancer is a life-threatening disease all over the world and is linked to constant oxidative stress and inflammation. Epigallocatechin gallate (EGCG), is a naturally occurring flavone possessing health benefiting pharmacological properties including antioxidant, anti-inflammatory and free radical scavenging properties. Our study investigates the role of EGCG on N,N′-dimethylhydrazine (DMH), a toxic environmental pollutant, induced colon toxicity. To investigate the effect of EGCG, Wistar rats were given EGCG for 7 days at the two doses of 10 and 20 mg/kg body weight and DMH was injected on the seventh day in all the group rats except the control. Our results indicate that DMH administration increased the oxidative stress (MDA) and depleted the glutathione and antioxidant enzyme activities (SOD, CAT, GR, GST and GPx) which was significantly ameliorated by EGCG treatment. Additionally DMH treatment upregulated inflammatory markers expression (NF-κB, COX-2 and IL-6) and enhanced mucosal damage in the colon. EGCG treatment significantly reduced inflammation and restored the normal histoarchitecture of the colon. We can conclude from the present study findings that EGCG protects the colon from DMH toxicity through its antioxidant and anti-inflammatory potential.

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Section: Discussionmentioning

confidence: 99%

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

et al. 2021

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Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

Segneanu,

Vlase,

Vlase

et al. 2023

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The current nanomedicinal approach combines medicinal plants and nanotechnology to create new scaffolds with enhanced bioavailability, biodistribution and controlled release. In an innovative approach to herb encapsulation in nanosized chitosan matrices, wild-grown Romanian Helleborus purpurascens was used to prepare two new chitosan nanocarriers. The first carrier preparation involved the nanoencapsulation of hellebore in chitosan. The second carrier emerged from two distinct stages: hellebore-AgNPs phyto-carrier system succeeded by nanoencapsulation in chitosan. The morphostructural characteristics and thermal behavior of these newly prepared nanocarriers were examined using FT-IR, XRD, DLS, SEM, EDS and thermogravimetric analyses. In addition, the encapsulation yield, encapsulation efficiency and encapsulation contents were investigated. The antioxidant activity was estimated using four in vitro, noncompetitive methods: total phenolic assay; 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay; phosphomolybdate (i.e., total antioxidant capacity); and iron(III)-phenanthroline antioxidant assay. Moreover, this study reports the first low-molecular-weight metabolite profile of wild-grown Romanian Helleborus purpurascens Waldst. & Kit. A total of one hundred and five secondary metabolites were identified in the mass spectra (MS)-positive mode from fourteen secondary metabolite categories (alkaloids, butenolides, bufadienolides, phytoecdysteroids, amino acids and peptides, terpenoids, fatty acids, flavonoids, phenolic acids, sterols, glycosides, carbohydrates, nucleosides and miscellaneous). The collective results suggest the potential application is a promising new antioxidant vehicle candidate in tumor therapeutic strategy.

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Phytochemical Study of Endemic Species Helleborus Caucasicus, Helleborus Abchasicus and Ficaria Popovii Spread in Southern Colchis

Cited by 2 publications

References 1 publication

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

Amelioration of N,N′-dimethylhydrazine induced colon toxicity by epigallocatechin gallate in Wistar rats

Wild-Grown Romanian Helleborus purpurascens Approach to Novel Chitosan Phyto-Nanocarriers—Metabolite Profile and Antioxidant Properties

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