Phytochemicals and cognitive health: Are flavonoids doing the trick?

Bakoyiannis, Ioannis; Daskalopoulou, Afrodite; Pergialiotis, Vasilios; Perrea, Despina

doi:10.1016/j.biopha.2018.10.086

Cited by 154 publications

(103 citation statements)

References 133 publications

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“…We also found a subgroup of genes involved in flavonoid regulation in the hippocampus affected by Hdac2 ASO1 treatment. Importantly, flavonoids are now being studied with regards to their role in cognitive enhancement and regulation of inflammation (Bakoyiannis et al 2019), suggesting there may be a link between the action of these compounds and Hdac2.…”

Section: Discussionmentioning

confidence: 99%

An antisense oligonucleotide leads to suppressed transcriptional elongation ofHdac2and long-term memory enhancement

et al. 2019

Preprint

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ABSTRACTRepression of the memory suppressor gene histone deacetylase 2 (Hdac2) in mice elicits cognitive enhancement, and drugs that block HDAC2 catalytic activity are being investigated for treating disorders affecting memory. Currently available compounds that target HDAC2 are not specific to the HDAC2 isoform, and have short half-lives. Antisense oligonucleotides (ASOs) are a class of drugs that base pair with RNA targets and exhibit extremely long-lasting, specific inhibition relative to small molecule drugs. We utilized an ASO to reduce Hdac2 messenger RNA (mRNA) quantities, and explored its longevity, specificity, and mechanism of repression. A single injection of the Hdac2-targeted ASO in the central nervous system diminished Hdac2 mRNA levels for at least 4 months in the brain, and knockdown of this factor resulted in significant memory enhancement for 8 weeks in mice. RNA-seq analysis of brain tissues revealed that the ASO repression was specific to the Hdac2 isoform relative to other classical Hdac genes, and caused alterations in levels of other memory-associated mRNAs. In cultured neurons, we observed that the Hdac2-targeted ASO suppressed Hdac2 mRNA and an Hdac2 non-coding regulatory extra-coding RNA (ecRNA). The ASO not only triggered a reduction in mRNA levels, but also elicited direct transcriptional suppression of the Hdac2 gene through blocking RNA polymerase II elongation. These findings suggest transcriptional suppression of the target gene as a novel mechanism of action of ASOs, and opens up the possibility of using ASOs to achieve lasting gene silencing in the brain without altering the nucleotide sequence of a gene.

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Section: Discussionmentioning

confidence: 99%

An antisense oligonucleotide leads to suppressed transcriptional elongation ofHdac2and long-term memory enhancement

et al. 2019

Preprint

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“…Plant hormones prevent cell membranes damage and its oxidation. Phytohormones exhibit inhibitory activity of collagenase, elastase and hyaluronidase -enzymes that cause water loss and reduce the skin elasticity, making it more susceptible to the aging processes [35]. In in vivo studies, a cream containing phytohormones caused a reduction in wrinkle depth after a few weeks of use [36].…”

Section: Phytohormonesmentioning

confidence: 99%

“…In addition, it has been shown that phytohormones can reduce the deposition of fat so can be successfully used in cosmetics that modelling the face oval. Common sources of these compounds are grapefruit, ginseng, dates, soybeans or wheat [35].…”

Section: Phytohormonesmentioning

confidence: 99%

“…www.journals.viamedica.pl/medical_research_journal Flavonoids Flavonoids are applied in skin care products mostly due to its powerful antioxidant properties, which can be up to 100 and 25-times stronger than vitamin C and vitamin E, respectively [35]. Furthermore, they accelerate wound healing, inflammatory and antibacterial processes.…”

Section: Phytohormonesmentioning

confidence: 99%

“…In an indirect way, flavonoids affect the condition of the blood vessels in the skin by stabilizing the unoxidized form of vitamin C, which is responsible for maintaining their cohesiveness. It was also shown that flavonoids inhibit elastase and hyaluronidase activity [35]. Flavonoids derived mainly from citrus fruits, tomatoes, vegetables, legumes, broccoli, blueberries, bilberries and grapes.…”

Section: Phytohormonesmentioning

confidence: 99%

See 2 more Smart Citations

Plant stem cells culture — a new tool for skin protection and regeneration

Kaźmierski

Roszkowski

2019

Medical Research Journal

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Development of biotechnology, esthetic medicine and cosmetology can enable us to slow down or delay the skin aging process. Currently, much attention is aimed at treatments using substances of plant origin. They have been proven to exhibit antioxidant, antibacterial and antifungal properties, accelerate wound healing, moisturize the skin, enhance skin renewal processes and protect skin against UV radiation. Biologically active plant-derived compounds, however, are often produced by plants in very small amounts. A solution to this problem is an in vitro culture of callus tissue, representing plant stem cells. Both, in vitro and in vivo studies demonstrated beneficial effects of plants stem cell extracts on human skin in the battle against ageing. The aim of this paper was to provide a review of studies based on the use of plant stem cells in limiting skin ageing.

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Neurotransmitter Modulation by Phytochemicals

Dubey¹,

Pandey

2023

Phytochemical Drug Discovery for Central Nervous System Disorders

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Phytochemicals and cognitive health: Are flavonoids doing the trick?

Cited by 154 publications

References 133 publications

An antisense oligonucleotide leads to suppressed transcriptional elongation ofHdac2and long-term memory enhancement

An antisense oligonucleotide leads to suppressed transcriptional elongation ofHdac2and long-term memory enhancement

Plant stem cells culture — a new tool for skin protection and regeneration

Neurotransmitter Modulation by Phytochemicals

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