2017
DOI: 10.3389/fphar.2017.00916
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Phytochemicals and PI3K Inhibitors in Cancer—An Insight

Abstract: In today's world of modern medicine and novel therapies, cancer still remains to be one of the prime contributor to the death of people worldwide. The modern therapies improve condition of cancer patients and are effective in early stages of cancer but the advanced metastasized stage of cancer remains untreatable. Also most of the cancer therapies are expensive and are associated with adverse side effects. Thus, considering the current status of cancer treatment there is scope to search for efficient therapies… Show more

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Cited by 44 publications
(31 citation statements)
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References 181 publications
(195 reference statements)
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“…Overall, scientific data have documented that this type of metabolites exerts an inhibitory effect on a broad range of mammalian tumor cell lines in in vitro and in vivo systems [ 8 , 9 ]. According to the literature, the main mammalian cellular and molecular mechanisms influenced by plant molecules are those that involve the following targets: nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB); protein tyrosine kinases (PTKs); target mitogen-activated protein kinases (MAPKs); cyclooxygenase (COX-2); cyclin-dependent kinases (Cdks); phosphoinositide 3-kinase (PI3K) interactors; activator protein 1 (AP1); and cytoskeleton components [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Overall, scientific data have documented that this type of metabolites exerts an inhibitory effect on a broad range of mammalian tumor cell lines in in vitro and in vivo systems [ 8 , 9 ]. According to the literature, the main mammalian cellular and molecular mechanisms influenced by plant molecules are those that involve the following targets: nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB); protein tyrosine kinases (PTKs); target mitogen-activated protein kinases (MAPKs); cyclooxygenase (COX-2); cyclin-dependent kinases (Cdks); phosphoinositide 3-kinase (PI3K) interactors; activator protein 1 (AP1); and cytoskeleton components [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ].…”
Section: Introductionmentioning
confidence: 99%
“…Phytochemicals are secondary plant metabolites and include flavonoids, triterpenoids, phenols, alkaloids, catechols, saponins, and tannins. Phytochemicals have been widely used for many decades in the prevention and treatment of various ailments, and current evidence suggests the use of phytochemicals as an effective treatment for cancer [ 9 ]. Phytochemicals, such as vincristine, taxanes, and camptothecin, which exhibit cytotoxic activities, contribute to the effective treatment of cancer.…”
Section: Introductionmentioning
confidence: 99%
“…These data revealed the key functions of circRNA_100269 and the potential mechanisms underlying the growth and metastasis of GC, which provided substantial evidences on the roles of circRNA_100269 in tumourogenesis. At present, inhibition of PI3K/Akt signaling is considered as a potential therapeutic approach in cancer treatment (28)(29)(30)(31)(32)(33). CircRNA_100269/PI3K/Akt axis could be a putative therapeutic target for the treatment of GC.…”
Section: Resultsmentioning
confidence: 99%