Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (<i>Zingiber officinale</i>) on diethylnitrosamine toxicity in rats

Fahmi, Abdelgawad A.; Hassanen, Naglaa H. M.; Abdur-Rahman, Mariam; Shams-Eldin, Engy

doi:10.1080/1354750x.2019.1606280

Cited by 37 publications

(17 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The components of vitamin E, curcumin or ginger may stabilize hepatocytes plasma membrane or preserve the structural integrity of hepatocellular membrane and prevent transmission of enzymes to the extracellular fluid as reported by the previous reports [1,46]. Similar results were previously obtained and confirmed our findings [47][48][49][50].…”

Section: Resultssupporting

confidence: 93%

Title: Effect of Curcumin and Ginger on Adverse Effects of Levofloxacin in Male Rats

Ibrahim

Abdallah

El-Gazzar

2021

Zagazig Veterinary Journal

View full text Add to dashboard Cite

Fluoroquinolones are more likely than any other antibacterial drug classes to cause serious side effects. The purpose of this study is to assess the protective effects of vitamin E, curcumin, and ginger in male rats against the side effects of levofloxacin (LFX).Ninety male Wistar rats were placed into six groups, each of 15 animals. Groups 1 and 2 received distilled water or olive oil and kept as normal controls, while groups 3-6 received LFX [10 mg/kg body weight (BW)] alone or in combination with vitamin E (100 mg/kg BW.), curcumin (200 mg/kg BW.) or ginger (200 mg/kg BW.), respectively. All medications were administered orally via gavage once a day for 5 successive days. Samples of blood were collected at zero day , 7 th and 14 th day post-treatments for biochemical analysis, while liver and kidney tissues were dissected and subjected to antioxidants estimation. Levofloxacin administration caused hepatic and renal damage evidenced by significant increase in serum liver enzymes, urea (76.43±3.70, 72.67±0.47, 75.00±6.42), creatinine (2.48±0.01, 2.48±0.01, 2.50±0.01), total cholesterol (166. 67±6.81, 174.00±4.04, 176.00±2.88), triglycerides (269.67±5.84, 289.33± 4.91, 249.67±1.86), and low density lipoprotein-cholesterol (LDL-C) (243.00±7.09, 213.67± 5.03, 226.33±5.45) levels. Meanwhile, significant decline in serum levels of high density lipoprotein-cholesterol (HDL-C) (20. 00±1.11, 23.33±3.38, 20.10±1.53), total protein (5.77±0.03, 5.97±0.09, 5.87±0.09), albumin (3.45±0.03, 3.60±0.06, 3.57±0.09) and A/G ratio (1.49±0.02, 1.51±0.05, 1.55±0.09) were determined in relation to normal control at zero, 7 th and 14 th day post-treatments, respectively in a time dependent manner. The superoxide dismutase (SOD) and glutathione peroxidase (GPx) activities in the liver (1

show abstract

Section: Resultssupporting

confidence: 93%

Title: Effect of Curcumin and Ginger on Adverse Effects of Levofloxacin in Male Rats

Ibrahim

Abdallah

El-Gazzar

2021

Zagazig Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…Furthermore, the administration of 6-shogaol in mice has also been shown to reduce the function of diethylnitrosamine and gene expression of hepatic antioxidant enzymes, including GPx, SOD and CAT (Fahmi et al, 2019). In our results, the meta-analysis also indicated that ginger supplementation significantly increases TAC levels.…”

Section: Discussionsupporting

confidence: 70%

“…It has been determined that 6‐shogaol achieves its effects through the phosphorylation of mitogen‐activated protein kinases (MAPKs), such as p38, extracellular signal‐regulated kinase (ERK), and c‐Jun N‐terminal kinase (JNK) (Wu et al., 2010). Furthermore, the administration of 6‐shogaol in mice has also been shown to reduce the function of diethylnitrosamine and gene expression of hepatic antioxidant enzymes, including GPx, SOD and CAT (Fahmi et al., 2019). In our results, the meta‐analysis also indicated that ginger supplementation significantly increases TAC levels.…”

Section: Discussionmentioning

confidence: 99%

Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

et al. 2021

View full text Add to dashboard Cite

A wide variety of antioxidant properties are attributed to ginger (Zingiber officinale) and several randomized controlled trials (RCTs) have investigated the effect of ginger intake on major oxidative stress (OS) parameters. We conducted a systematic review and meta-analysis to evaluate the effects of using ginger to improve OS levels. Medline, Scopus, ISI Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched up until March 2020 to gather RCTs that evaluated the impact of ginger intake on the levels and activity of OS parameters in adult subjects. Means and standard deviations for relevant OS variables were extracted and evaluated to assess the quality of the trials based on the Cochrane riskof-bias tool for randomized trials. The gathered data were pooled and expressed as standardized mean difference (SMD) with 95% Confidence Intervals (95% CI). Twelve trials were included in this review. Ginger intake was shown to significantly increase glutathione peroxidase (GPx) activity (SMD: 1.64; 95% CI: 0.43, 2.85; I 2 = 86.8%) and total antioxidant capacity (TAC) (SMD: 0.40; 95% CI: 0.06, 0.73; I 2 = 42.8%) and significantly decrease malondialdehyde (MDA) levels (SMD: −0.69; 95% CI: −1.26, −0.12; I 2 = 85.8%) compared to control groups. Ginger supplementation also non-significantly associated with an increase in CAT activity (SMD: 1.09; 95% CI: −0.07, 2.25; I 2 = 87.6%). This systematic review and meta-analysis presents convincing evidence supporting the efficacy of ginger supplementation on improving OS levels. Practical implications: In health sciences, OS, due to its pivotal role in the pathophysiology of several chronic diseases, is a subject with a long history. Recent research strives for a safe, ideal, and effective antioxidant. Ginger is herbal medicine, which has been widely used in traditional and complementary medicine. Proving the antioxidant effect and potential benefit of ginger has positive clinical implications for the application of this practical herb.

show abstract

“…is was supported by another finding which reported that 6-gingerol in ginger extract has the ability to increase the expression of antioxidant enzyme as well as restore glutathione level [29]. e antioxidant properties of ginger have also been reported in a study carried out by Fahmi et al [51] which found that ginger extract was able to lessen the severity of diethylnitrosamine (DEN) toxicity in rats by increasing the level of serum high-density lipoprotein (HDL) and plasma glutathione peroxidase (GSH-Px) activity, accompanied by decreased low-density lipoprotein (LDL), serum alanine aminotransferase (ALT), and alkaline phosphatase (ALP). In another study, ginger has been proven to attenuate lipid peroxidation with reduction of MDA level and increase glutathione S-transferase activity in the liver of Wistar rats [52].…”

Section: Evidence-based Complementary and Alternative Medicinementioning

confidence: 55%

Zingiber officinale Roscoe Prevents DNA Damage and Improves Muscle Performance and Bone Integrity in Old Sprague Dawley Rats

Makpol

Sani

Hakimi

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Age-related loss of skeletal muscle mass and strength or sarcopenia is attributed to the high level of oxidative stress and inadequate nutritional intake. The imbalance in oxidative status with increased production of free radicals results in damage to the DNA which leads to cell dysfunction. This study aimed to determine the effect of Zingiber officinale Roscoe (ginger) on muscle performance and bone integrity in Sprague Dawley (SD) rats. SD rats aged three (young), nine (adult), and twenty-one (old) months old were treated with either distilled water or ginger extract at a concentration of 200 mg/kg body weight (BW) daily for 3 months via oral gavage. Muscle performance was assessed at 0, 1, 2, and 3 months of treatment by measuring muscle strength, muscle function, and bone integrity while DNA damage was determined by comet assay. Muscle cell histology was analyzed by hematoxylin and eosin (H&E) staining. Young and adult ginger-treated rats showed a significant improvement in muscle strength after 3 months of supplementation. Bone mineral density (BMD) and bone mineral content (BMC) were increased while fat free mass (FMM) was decreased after 3 months of ginger supplementation in young rats but not changed in adult and old ginger supplemented groups. Interestingly, supplementation of ginger for 3 months to the old rats decreased the level of damaged DNA. Histological findings showed reduction in the size of muscle fibre and fascicles with heterogenous morphology of the muscle fibres indicating sarcopenia was evident in old rats. Treatment with ginger extract improved the histological changes even though there was evidence of cellular infiltration (mild inflammation) and dilated blood vessels. In conclusion, Z. officinale Roscoe prevents DNA damage and improves muscle performance and bone integrity in SD rats indicating its potential in alleviating oxidative stress in ageing and thus delaying sarcopenia progression.

show abstract

Phytochemicals, antioxidant activity and hepatoprotective effect of ginger (Zingiber officinale) on diethylnitrosamine toxicity in rats

Cited by 37 publications

References 64 publications

Title: Effect of Curcumin and Ginger on Adverse Effects of Levofloxacin in Male Rats

Title: Effect of Curcumin and Ginger on Adverse Effects of Levofloxacin in Male Rats

Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

Zingiber officinale Roscoe Prevents DNA Damage and Improves Muscle Performance and Bone Integrity in Old Sprague Dawley Rats

Contact Info

Product

Resources

About