Effect of ginger ( Zingiber officinale ) supplementation on oxidative stress parameters: A systematic review and meta‐analysis

Abstract

A wide variety of antioxidant properties are attributed to ginger (Zingiber officinale) and several randomized controlled trials (RCTs) have investigated the effect of ginger intake on major oxidative stress (OS) parameters. We conducted a systematic review and meta-analysis to evaluate the effects of using ginger to improve OS levels. Medline, Scopus, ISI Web of Science, EMBASE, and the Cochrane Central Register of Controlled Trials were systematically searched up until March 2020 to gather RCTs that evaluated the impact of ginger intake on the levels and activity of OS parameters in adult subjects. Means and standard deviations for relevant OS variables were extracted and evaluated to assess the quality of the trials based on the Cochrane riskof-bias tool for randomized trials. The gathered data were pooled and expressed as standardized mean difference (SMD) with 95% Confidence Intervals (95% CI). Twelve trials were included in this review. Ginger intake was shown to significantly increase glutathione peroxidase (GPx) activity (SMD: 1.64; 95% CI: 0.43, 2.85; I 2 = 86.8%) and total antioxidant capacity (TAC) (SMD: 0.40; 95% CI: 0.06, 0.73; I 2 = 42.8%) and significantly decrease malondialdehyde (MDA) levels (SMD: −0.69; 95% CI: −1.26, −0.12; I 2 = 85.8%) compared to control groups. Ginger supplementation also non-significantly associated with an increase in CAT activity (SMD: 1.09; 95% CI: −0.07, 2.25; I 2 = 87.6%). This systematic review and meta-analysis presents convincing evidence supporting the efficacy of ginger supplementation on improving OS levels. Practical implications: In health sciences, OS, due to its pivotal role in the pathophysiology of several chronic diseases, is a subject with a long history. Recent research strives for a safe, ideal, and effective antioxidant. Ginger is herbal medicine, which has been widely used in traditional and complementary medicine. Proving the antioxidant effect and potential benefit of ginger has positive clinical implications for the application of this practical herb.

Zingiberaceae plants/curcumin consumption and multiple health outcomes: An umbrella review of systematic reviews and meta‐analyses of randomized controlled trials in humans

“…In terms of antioxidant effects, low‐quality meta‐analyses indicated that ginger of the Zingiberaceae plants and the functional components of turmeric, mainly reduced malondialdehyde (MDA) and increase the level of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH‐Px) (Alizadeh et al, 2019; Jalali, Mahmoodi, Moosavian, et al, 2020; Morvaridzadeh et al, 2021; Sahebkar et al, 2015). It was not ignored that the results of two meta‐analysis which showed that Cur supplementation had no significant effect on CAT (GRADE level: very low) and total antioxidant capacity (TAC) (GRADE level: low) (Alizadeh & Kheirouri, 2019; Morvaridzadeh et al, 2021). None of the articles mentioned above reported publication bias.…”

“…c Fixed-effects model. d Egger's regression test p-value.peroxidase (GSH-Px)(Alizadeh et al, 2019;Morvaridzadeh et al, 2021;Sahebkar et al, 2015). It was not ignored that the results of two meta-analysis which showed that Cur supplementation had no significant effect on CAT (GRADE level: very low) and total antioxidant capacity (TAC) (GRADE level: low) (Alizadeh & Kheirouri, 2019; Morvaridzadeh3.4 | Osteoarthritis and pain managementOur analysis found that Zingiberaceae plants, especially ginger, have a positive effect on knee osteoarthritis (Araya-Quintanilla et al, 2020;T A B L E 5Abbreviations: CI, confidence interval; cont, control; Cur, curcumin; int, intervention; IBS, irritable bowel syndrome; MA, meta-analysis; NA, not available; OR, odds ratio; RCT, randomized controlled trial; RR, relative risk; SMD, standardized mean difference; UC, ulcerative colitis.a Total participants.…”

Shen-su-yin, a Traditional Herbal Medicine, Attenuates Lipopolysaccharide-induced Acute Lung Injury in Rats Through Its Anti-inflammatory and Anti-oxidative Effects

“…Most Chinese herbs present in SSY, including Panax ginseng [20], Folium perillae [21], Pueraria lobata [22], Poria cocos [23], Fructus aurantii [24], Platycodon grandi orum [25], pericarpium citri reticulatae [26], Glycyrrhiza uralensis sch [27], Costus root [28], Zingiber O cinale Radix [29] and Zizyphi fructus [30], have shown anti-in ammatory and/or anti-oxidative effects. Additionally, Peucedani radix, another component of SSY, exhibits a wide spectrum of pharmacological activities including anti-infective, antitussive, anti-asthmatic and expectorant effects, which help relieve symptoms and improve ALI prognosis [31].…”

Glyphosate-induced liver and kidney dysfunction, oxidative stress, immunosuppression in Nile tilapia, but ginger showed a protection role

“…The high pharmacological potential of medicinal herbs as natural antioxidative and anti-inflammation agents suggests using these additives to relieve the impacts of herbicides, insecticides, and pesticides on aquatic animals (Sinha et al 2021;Yousefi et al 2021). Zingiber officinale or ginger is a natural medicinal plant with high bioactive properties (Morvaridzadeh et al 2020(Morvaridzadeh et al , 2021. The dietary inclusion of ginger led to marked enhancement in the growth performance, intestinal health, digestion capacity, antioxidative, and immune responses of several fish species (Chung et al 2021b;Fazelan et al 2020;Korni and Khalil 2017).…”