Phytochemicals for Breast Cancer Therapy: Current Status and Future Implications

Siddiqui, Jawed A.; Singh, Amresh Kumar; Chagtoo, Megha; Singh, Nidhi; Godbole, Madan M.; Chakravarti, Bandana

doi:10.2174/1568009615666141229152256

Cited by 58 publications

(29 citation statements)

References 171 publications

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“…Increasingly, various medicinal plants are being screened for anticancer properties and may provide effective therapeutic agents. Numerous phytoconstituents against breast tumour cells are well documented as well as those preventing the occurrence of mammary tumours in various experimental animal models via modulation of proliferation, differentiation, apoptosis, oxidative stress, inflammation, angiogenesis and several cell signalling pathways involved in breast cancer (Sinha et al, 2012;Reuben et al, 2012;Vadodkar et al, 2012;Parikh et al, 2014;Siddiqui et al, 2015;Magne Nde et al, 2015;Sinha et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Crateva adansonii DC, an African ethnomedicinal plant, exerts cytotoxicity in vitro and prevents experimental mammary tumorigenesis in vivo

Zingue

Cisilotto

Tueche

et al. 2016

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 99%

Crateva adansonii DC, an African ethnomedicinal plant, exerts cytotoxicity in vitro and prevents experimental mammary tumorigenesis in vivo

Zingue

Cisilotto

Tueche

et al. 2016

Journal of Ethnopharmacology

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“…We and other groups have summarized anticancer abilities of phytochemicals and their importance in drug development [8,9,18–23]. Moreover, Siddiqui et al [24] have recently reviewed the current status of phytochemicals against breast cancer, while in the present review article, we summarize a number of phytochemicals affecting CSCs. Several epidemiological studies have correlated the consumption of phytochemicals and reduced risk of cancer.…”

Section: Introductionmentioning

confidence: 94%

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

Dandawate

Subramaniam

Jensen

et al. 2016

Seminars in Cancer Biology

264

154

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Breast cancer is the most common form of cancer diagnosed in women worldwide and the second leading cause of cancer-related deaths in the USA. Despite the development of newer diagnostic methods, selective as well as targeted chemotherapies and their combinations, surgery, hormonal therapy, radiotherapy, breast cancer recurrence, metastasis and drug resistance are still the major problems for breast cancer. Emerging evidence suggest the existence of cancer stem cells (CSCs), a population of cells with the capacity to self-renew, differentiate and be capable of initiating and sustaining tumor growth. In addition, CSCs are believed to be responsible for cancer recurrence, anticancer drug resistance, and metastasis. Hence, compounds targeting breast CSCs may be better therapeutic agents for treating breast cancer and control recurrence and metastasis. Naturally occurring compounds, mainly phytochemicals have gained immense attention in recent times because of their wide safety profile, ability to target heterogeneous populations of cancer cells as well as CSCs, and their key signaling pathways. Therefore, in the present review article, we summarize our current understanding of breast CSCs and their signaling pathways, and the phytochemicals that affect these cells including curcumin, resveratrol, tea polyphenols (epigallocatechin-3-gallate, epigallocatechin), sulforaphane, genistein, indole-3-carbinol, 3, 3′-diindolylmethane, vitamin E, retinoic acid, quercetin, parthenolide, triptolide, 6-shogaol, pterostilbene, isoliquiritigenin, celastrol, and koenimbin. These phytochemicals may serve as novel therapeutic agents for breast cancer treatment and future leads for drug development.

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“…Literature survey lead to the identification of 18 natural compounds that are belonging to Flavonoids, Isoflavones, Catechine, polyphenolic and terpenophenolic families [18] and 26 Chemical drugs approved by the Food and Drug Administration (FDA) for Breast Cancer treatment [19]. The 3D structures of these natural compounds and chemical drugs are downloaded from the PubChem database [20] in SDF format and they are converted to the PDB format using Open Babel version 2.3.2 software [21].…”

Section: Ligand Archive Researchmentioning

confidence: 99%

Untitled

2017

JCPCR

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Background: Molecular docking is used to identify natural phytochemical and commercial drugs that are equivalent to treat BRCA1-based breast cancers. BRCA1 type breast cancers have high mortality and recurrence rate. BRCA 1 gene, which is also known as Breast Cancer Susceptibility Gene 1, has a high probability of mutation or duplication, which further leads to breast cancer. Materials and Methods:There are numerous phytochemical and chemical drugs that are administered against breast cancer. These compounds are taken from the literature survey and they are meant to drug screening process against BRCA1 receptor (PDBID-4Y2G) using iGEMDOCKv2.1 and further the binding site of the Receptor is determined and the top 5 molecules that were attained from both phytochemicals and commercial drugs are proceeded to Active Site docking using Autodock vina software. Results:Based on their Drug Screening scores and Binding affinity scores, one best phytochemical Epi Gallo Catechin Gallate-EGCG (Green tea extract), and one commercial drug, Doxorubicin Hydrochloride with best energies from docking are obtained. Keywords: Molecular Docking; BRCA1; Drug Screening; EGCG; Doxorubicin Hydrochloride IntroductionComputer-Aided-Drug-Discovery approaches have been extensively used in drug investigation to increase the efficiency of the drug discovery and development pipeline, subject to the purpose and systems of interest [1]. Docking is a software technique that fits a molecule into target binding sites. It is used for binding modes of protein with ligands and inhibitors [2]. It is used to predict the structure of the intermolecular complex formed between two or more molecules. Thus, it is used for drug discovery and matching molecules, with overall minimum energy. In this research, the equivalent natural phytochemical and commercial drugs are identified using molecular docking for treating BRCA1 breast cancer.The BRCA1 gene is situated on the long arm of Chromosome 17 at 17q21 and BRCA1 also contains 24 coding exons that range over 80 kb [3]. BRCA1 was first mapped and was consequently cloned in the years 1990 and 1994 [4,5]. BRCA1 interacts with quite a lot of proteins that are involved in cell cycle progression, cellular pathways, ubiquitination, gene transcription regulation and DNA damage response [6]. BRCA1 is a pleiotropic DNA Damage Response protein (DDR) that functions in both DNA activation and checkpoint repair [7]. BRCA1 can bind to RAD51, p53, RAD50-MRE11-NBS1 (R-M-N) complex, leading to homologous recombination or Non-Homologous End-Joining (NHEJ) which is having excessive importance in DNA damage and its repair [8]. Deficiency in BRCA1 as a result causes abnormalities in the centrosome duplication, the G2/M checkpoint, the spindle checkpoint and S-phase checkpoint [9]. One of the most important features of BRCA1-associated breast cancer is that it comprises a complex unit of aneuploidy than tumours without Breast Cancer Susceptibility gene 1 mutations [10]. HCC1937 cell line derived from homozygous BRCA1 deficien...

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Phytochemicals for Breast Cancer Therapy: Current Status and Future Implications

Cited by 58 publications

References 171 publications

Crateva adansonii DC, an African ethnomedicinal plant, exerts cytotoxicity in vitro and prevents experimental mammary tumorigenesis in vivo

Crateva adansonii DC, an African ethnomedicinal plant, exerts cytotoxicity in vitro and prevents experimental mammary tumorigenesis in vivo

Targeting cancer stem cells and signaling pathways by phytochemicals: Novel approach for breast cancer therapy

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