Phytochemicals from Rhizophora mucronata Propagules, Its In Vitro Anti-Cancer and In Silico Drug-Likeness Potential

Yunos, N. M.; Ling, Sui Kiong; Osman, Asiah; Abdullah, Zanariah; Sallehudin, Nor Jannah

doi:10.3390/chemistry3030070

Cited by 3 publications

(1 citation statement)

References 42 publications

(47 reference statements)

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“…This study revealed that the greatest anticancer effects of both of the parts of R. mucronata was on the colon (CaCo-2) and breast (MCF-7) cancer cell lines. This observation agrees with the results reported by Yunos et al [45], who found that Epicatechin, 4-O-caffeoyl quinic acid, 5-Ocaffeoyl quinic acid, and procyanidin B2 isolated from R. mucronata showed strong to moderate anticancer effects on colorectal (HT29) and breast (T47D) cancer cell lines. These results also agree with existing studies on the polyisoprenoids from R. mucronata leaves that induce apoptosis in WiDr colon cancer cells by reducing the expression of Bcl-2 and cyclin D1, consequently causing cell cycle arrest [25].…”

Section: Discussionsupporting

confidence: 93%

Phytochemistry and Anticancer Effects of Mangrove (Rhizophora mucronata Lam.) Leaves and Stems Extract against Different Cancer Cell Lines

2022

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The biologically active components of the methanol extracts of R. mucronata were identified using GC/MS. The anticancer effects of each methanol extract from the leaves and stem were evaluated against cancer and non-cancer cell lines. The MTT assay was used in order to evaluate cell viability, and the IC50 and the selectivity indices were calculated in relation to a positive control (doxorubicin). The results showed that 11 and 8 different chemical compounds were found in the methanol extracts from the leaves and stems of R. mucronata, respectively. The active constituents of R. mucronata leaves and stems had anticancer effects against colon cancer (CaCo-2), with IC50 levels of 127 ± 4 μg/mL and 107 ± 6 μg/mL, respectively, and on breast cancer (MCF-), with IC50 levels of 158 ± 10 μg/mL and 138 ± 4 μg/mL, respectively. These were both greater than their effects on prostate cancer (PC-3), for which they showed IC50 levels of 480 ± 14 μg/mL and 294 ± 3 μg/mL, respectively. However, the anticancer effect of the stems on lung cancer (A549) (IC50 = 155 ± 10 μg/mL) was greater than that of the leaves (IC50 = 376 ± 9 μg/mL) in comparison with doxorubicin. Neither the stems nor the leaves of R. mucronata showed any cytotoxicity against normal cells (WI-38), with the IC50 being 932 ± 30 μg/mL for the leaves and 629 ± 3 μg/mL for the stems.

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Section: Discussionsupporting

confidence: 93%

Phytochemistry and Anticancer Effects of Mangrove (Rhizophora mucronata Lam.) Leaves and Stems Extract against Different Cancer Cell Lines

2022

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Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria

Chelliah,

Murugan,

Rajivgandhi

et al. 2023

Journal of King Saud University - Science

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Review of Malaysian Medicinal Plants with Potential Anticancer Activity

Jusoh

Aris

Jalil

et al. 2023

MAB

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The global cancer incidence and its high mortality rate indicate limitations in its current treatment and chemotherapeutic strategies. This sparked a worldwide interest in the demand for chemical diversity in searching for therapeutic drugs derived from natural products. Natural products from medicinal plants, whether as pure compounds or crude extracts, offer inexhaustible sources of new drugs because of their unparalleled chemical diversity. This review aims to disseminate detailed information on the anticancer potential of Malaysian medicinal plants, focusing on the bioactive phytochemicals and mechanisms of action against cancer development in both in vitro and in vivo studies. A comprehensive search of PubMed, Google Scholar, Scopus, and ScienceDirect databases was conducted to find relevant articles on the anticancer activity of Malaysian medicinal plants. A total of hundred and twenty-two (122) articles on the anticancer activity of Malaysian medicinal plants was identified and reviewed. Eighty-five (85) plants (in vitro) and 16 plants (in vivo) have been identified to possess anticancer activity. The activity reported was attributed primarily to diverse chemical groups of naturally occurring phytochemicals such as flavonoids, phenolics, glycosides, quercetin, and gallic acid. Henceforth, the findings will hope to aid further research in understanding the underlaying mechanism and the efficiency of the isolation of the bioactive compounds.

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Phytochemicals from Rhizophora mucronata Propagules, Its In Vitro Anti-Cancer and In Silico Drug-Likeness Potential

Cited by 3 publications

References 42 publications

Phytochemistry and Anticancer Effects of Mangrove (Rhizophora mucronata Lam.) Leaves and Stems Extract against Different Cancer Cell Lines

Phytochemistry and Anticancer Effects of Mangrove (Rhizophora mucronata Lam.) Leaves and Stems Extract against Different Cancer Cell Lines

Phytochemical derivatives and secondary metabolites rich Rhizophora mucronata as an active anti-oxidant and anti-bacterial agent against multi drug resistant bacteria

Review of Malaysian Medicinal Plants with Potential Anticancer Activity

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