Phytochemicals in the Fight Against Cancer

Davidson, Kristoffer T; Zhu, Ziwen; Fang, Yujiang

doi:10.1007/s12253-016-0045-x

Cited by 14 publications

(8 citation statements)

References 48 publications

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“…Similar kind of findings were observed when rat models were treated with C. papaya L. induced by acetaminophen [42]. It is highly observed that antioxidants have tissue repairing capacity [43] and fight against foreign invaders, thus protecting tissue [44]. We assume due to having strong antioxidant property of the Syzygium cumini seed, the supplement considerably reduced tissue necrosis and damage which is clearly observed by our histology pictures ( Figures 5D-11D).…”

Section: Discussionsupporting

confidence: 86%

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Sagor¹,

Mohib²,

Tabassum³

et al. 2016

J Drug Metab Toxicol

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Nowadays, the drug induced organ damage has increased drastically. Similarly, number of Adverse Drug Reactions (ADR) is on the rise. Unwanted and harmful effects of a drug have been a good reason for early withdrawal of a good molecule from the market or clinical trial. In the present study, we have investigated the preventive role of Syzygium cumini against Acetaminophen induced organ damage. In this study, four different groups of rats were evaluated. Group A serves as a control group, Group B serves as control + Syzygium cumini group, Group C serves as disease group and Group D serves as disease + treatment group. Only two groups have been treated and exposed to an overdose of acetaminophen. However, liver and kidney markers like Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Creatinin and Uric acid (UA) were measured respectively. Moreover, oxidative stress markers such as Malondialdehyde (MDA), Nitric Oxide (NO) and Advanced Oxidation Protein Product (AOPP) were found higher in acetaminophen overdose rats compared to control rats. Furthermore, antioxidant enzymes like Catalase (CAT), Superoxide Dismutase (SOD) and Linear Peptide Glutathione (GSH) were restored significantly by Syzygium cumini seed treatment. Finally, our study revealed that supplementation of 1% Syzygium cumini seed with food attenuated inflammatory cell infiltration, collagen secretion, extracellular matrix deposition and iron overload in both hepatic and kidney. We assume that the protection might be achieved due to having strong antioxidant properties of Syzygium cumini.

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Section: Discussionsupporting

confidence: 86%

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Sagor¹,

Mohib²,

Tabassum³

et al. 2016

J Drug Metab Toxicol

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“…Phytochemicals are secondary metabolites from plants responsible for the taste, color, and aroma of fruit. Research suggests that phytochemicals are beneficial in preventing and treating oxidative damage and inflammation, which are important risk factors in cancer development [36][37][38][39]. Moreover, phytochemicals have significant onco-preventive and chemo-protective effects, and this has been reviewed extensively elsewhere [38,[40][41][42][43][44][45].…”

Section: Importance Of Phytochemicals From Diet In Management Of Cancermentioning

confidence: 99%

“…Multiple studies have demonstrated that apple phytochemicals can inhibit the activity of p21, growth factors, pyruvate dehydrogenase kinases (PDKs), cyclin-dependent kinases (CDKs), and extracellular protein kinases (ERKs) essential for cell cycle progression [37,126,131,132]. Furthermore, apple phytochemicals can also prevent cell cycle progression by activation of maspin, a tumor suppressor gene [127].…”

Section: In Vitro and In Vivo Evidence Of The Anticancer Properties Of Apple Phytochemicalsmentioning

confidence: 99%

Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds

Nezbedova

McGhie

Christensen³

et al. 2021

Nutrients

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Cancer is one of the leading causes of death globally. Epidemiological studies have strongly linked a diet high in fruits to a lower incidence of cancer. Furthermore, extensive research shows that secondary plant metabolites known as phytochemicals, which are commonly found in fruits, have onco-preventive and chemo-protective effects. Apple is a commonly consumed fruit worldwide that is available all year round and is a rich source of phytochemicals. In this review, we summarize the association of apple consumption with cancer incidence based on findings from epidemiological and cohort studies. We further provide a comprehensive review of the main phytochemical patterns observed in apples and their bioavailability after consumption. Finally, we report on the latest findings from in vitro and in vivo studies highlighting some of the key molecular mechanisms targeted by apple phytochemicals in relation to inhibiting multiple ‘hallmarks of cancer’ that are important in the progression of cancer.

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“…Авторы приписывают такой эффект высокому содержанию в яблоках флавоноидов (катехинов, флавонолов) и фенольных кислот. На выраженное противораковое действие полифенолов яблок, в том числе и экстракта яблочных полифенолов, указывают и американские ученые [17].…”

Section: результаты и обсуждениеunclassified

Vegetables and fruits in the prevention and treatment of cancer in the light of evidence-based medicine (part 1)

Zakrevskii¹,

Liflyandsky²

2017

Vestnik SPbSU. Medicine

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1 Северо-Западный государственный медицинский университет им. И. И. Мечникова, Российская Федерация, 191015, Санкт-Петербург, ул. Кирочная, 41 10.21638/11701/spbu11.2017.409 Проанализировано влияние овощей и плодов на риск развития различных типов онкологических заболеваний и обоснована возможность их использования в профилактике рака и повышении качества жизни больных раком. Наиболее выраженные профилактические свойства установлены у яблок и цитрусовых, темных сортов винограда, черники, черной смородины, малины (особенно ежевикообразной), овощей, содержащих каротиноиды (томаты, морковь, тыква и др.), а также луковых, крестоцветных и листовых овощей. Как одни из наиболее эффективных противораковых компонентов проявили себя пищевые волокна в составе продуктов питания. Пищевые волокна в составе биологически активных добавок противоракового действия не оказывали, а иногда повышали риск развития некоторых онкологических заболеваний. Противораковое действие также установлено для многих фитонутриентов, входящих в состав различных овощей и плодов, -антиоксидантов, каротиноидов, фолатов, флавоноидов, изотиоцианатов, ресвератрола, аллицина и диалилсульфида, но не для биологически активных добавок, содержащих указанные соединения. Доказана опасность избыточного потребления таких нутриентов, как селен, альфа-токоферол и омега-3 жирные кислоты, которые, в частности, повышали риск развития рака предстательной железы, каротиноидырака легких, а комплексные биологически активные добавки с антиоксидантами -рака мочевого пузыря. Овощи, консервированные солением и маринованием, а также жареные повышают риск развития рака, в основном органов пищеварения. Бесконтрольное применение БАД с селеном, альфа-токоферолом, омега-3 жирными кислотами, каротиноидами и другими нутриентами способно провоцировать ракообразование. Библиогр. 51 назв.Ключевые слова: овощи, фрукты, ягоды, профилактика и лечение рака, доказательная медицина.Surveys of existing literature analyzed the effect of vegetables and fruits on the risk of developing various types of cancer and justified the possibility of their use for the prevention of the risk of cancer and the improvement of the quality of life in patients with cancer. Apples and citrus have the Вестник СПбГУ. Медицина. 2017. Т. 12. Вып. 4 most pronounced prophylactic properties along with dark grapes, blueberries, black currants, and blackberries, vegetables containing carotenoids (tomatoes, carrots, pumpkin, etc.), as well as onion, cruciferous and leafy vegetables. Dietary fiber is one of the most effective anti-cancer components in food composition. The anticancer effects of dietary fiber in dietary supplements has not been not provided, and sometimes resulted in the increase of risk of certain cancers. Also installed the anti-cancer effect for many of the phytonutrients included in the composition of different vegetables and fruitsantioxidants, carotenoids, folate, flavonoids, isothiocyanates, resveratrol, allicin and diallylsulfide, but not for biologically active additives (dietary supplements) ...

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Phytochemicals in the Fight Against Cancer

Cited by 14 publications

References 48 publications

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Onco-Preventive and Chemo-Protective Effects of Apple Bioactive Compounds

Vegetables and fruits in the prevention and treatment of cancer in the light of evidence-based medicine (part 1)

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