Phytochemicals in the Treatment of Arthritis: Current Knowledge

Bhattacharya, Sourav; Mandal, Sudip Kumar; Akhtar, Md. Semimul; Dastider, Dipra; Sarkar, Sipra; Bose, Sankhadip; Bose, Anindya; Mandal, Sanjit; Kolay, Arindam; Sen, Dhrubo Jyoti; Kumar, Alok; Pan, Subham; Pramanick, Arghya

doi:10.22159/ijcpr.2020v12i4.39050

Cited by 8 publications

(6 citation statements)

References 36 publications

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“…Medicinal plants are valuable natural resources that are considered by the advanced countries of the world as raw materials to become safe medicines for human diseases (Bose et al, 2020;Bhattacharya et al, 2020). The present study was designed to assess the antioxidant effect of methanolic extract of F. vulgaris.…”

Section: Discussionmentioning

confidence: 99%

Determination of the Total Antioxidant Activity of Methanolic Extract of Falcaria Vulgaris

et al. 2022

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Introduction: A growing tendency to the administration of medicinal plants is observed because of their amazing influence on human health. Pharmaceutical and food industries recommend the use of medicinal plants due to their antioxidant properties. Hence, this study was conducted to examine the antioxidant activity of the methanolic extract of Falcaria vulgaris. Methods: Aerial parts of F. vulgaris were dried and ground. Then, plant samples were prepared using homogenizing plant powders in a methanol solution. Finally, the total antioxidant capacity of the plants was assessed by ferric reducing antioxidant power (FRAP) assay. Results: Our findings demonstrated that the total antioxidant capacity was obtained as 2.86 mmol Fe2+/L for the methanolic extract of F. vulgaris. Conclusion: According to the findings, F. vulgaris had a strong antioxidant capacity. It could be concluded that the administration of F. vulgaris in food and pharmaceutical industries could possibly affect positively human health.

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Section: Discussionmentioning

confidence: 99%

Determination of the Total Antioxidant Activity of Methanolic Extract of Falcaria Vulgaris

et al. 2022

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“…Around 20 million people around the world are estimated to be prone to RA conditions (Safiri et al, 2019). The currently available medications are shown to cause a lot of adversities such as heartburn, anemia, abdominal pain, peptic ulcer, gastrointestinal bleeding, cataracts, high/low blood pressure, insomnia, muscle atrophy, osteoporosis, body weight gain, and immunity loss upon continuous usage (Bhattacharya et al, 2020;Al-Lawati et al, 2020, Fischer et al, 2020. So, safe and efficient natural agents having the ability to manage or to inhibit the progress of the RA conditions are of great significance.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Anti-inflammatory, and Anti-arthritic Effect of Thymoquinone-rich Black Cumin (Nigella sativa) oil (BlaQmax®) on Adjuvant-induced Arthritis

Ratheesh¹,

Svenia²,

Saji³

et al. 2021

JFR

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Rheumatoid Arthritis (RA) is a complex autoimmune disorder involving chronic and persistent inflammation, principally influencing the synovial joints which further prompting the obliteration of articular cartilage. Although black cumin (Nigella sativa) oil has already studied for its anti-arthritic properties, the current study was focused on the comparative evaluation of the antioxidant and anti-inflammatory properties of a thymoquinone (TQ)-rich (5% w/v) black cumin oil (BQ) with the commonly available standard black cumin oil (BM) containing 0.4% (w/v) TQ, and subsequent investigation on the potential application of BQ in the management of RA. Adjuvant-induced arthritis (AA) was instigated by a single intradermal infusion of 0.1 mL of Complete Freund's adjuvant (CFA) on the paw of adult Wistar rats. Based on the primary dose-response study using the carrageenan-induced paw edema model, 50 mg/kg b.wt. of BQ was employed for the treatment. The endogenous antioxidants (SOD, Catalase, GPx, and GSH), pro-inflammatory cytokines (COX-2, Nitrate, iNOS, TNF-α, IL-6), lipid peroxidation, and histopathology were evaluated to monitor the influence of BQ in AA rats. Adjuvant-induced animals showed a critical downregulation in antioxidant status with elevated levels of pro-inflammatory cytokines and lipid peroxidation. But, the treatment with BQ significantly reversed the antioxidant and inflammatory markers with downregulation of the pro-inflammatory gene expressions. Histopathology showed a significant reduction in the massive cell infiltration and epidermal edema of the paw tissue in AA rats when administered with BQ and indicated its potential effect to alleviate RA conditions in experimental rats.

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“…Multiple studies have confirmed that the isoquinoline alkaloid norisoboldine (NOR) (compound 12 in Table 2 ) from LA-R is the most representative active compound and possesses outstanding anti-arthritis activity ( 82 ). In CIA rats, oral NOR (10, 20, and 40 mg/kg) significantly decreased the swelling of paws, arthritis index scores and elevated the lowered body weights of rats.…”

Section: Pharmacologymentioning

confidence: 99%

“…As shown in Table 1 and Figure 2, modern phytochemistry studies reveal that the sesquiterpenoids isolated from L. aggregata are mainly featured as monomer-, dimer-, and hybrid forms. The sesquiterpenoid monomers include eudesmane- , lindenane- , germacrane- (53)(54)(55)(56)(57)(58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68)(69), elemane-(70-73), guaiane- (74)(75)(76), cadinane- (77)(78), copane- (79), eremophilane- (80), and other types (81)(82)(83)(84) (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27). So far, the sesquiterpenes of L. aggregata account for more than half ...…”

Section: Sesquiterpenoidsmentioning

confidence: 99%

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

Zou²,

Zhang³

et al. 2023

Front. Nutr.

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Lindera aggregata (Sims) Kosterm. (L. aggregata), which belongs to the genus Lindera in the family Lauraceae, is widely distributed in Asia and the temperate, tropical regions of North America. Its roots and leaves have been used for thousands of years as traditional Chinese medicine and/or functional food. To further explore its underlying nutritional value, this review provided a comprehensive insight into chemical constituents and pharmacological effects on L. aggregata. The phytochemical investigation of different parts of L. aggregata led to the identification of up to 349 components belonging to sesquiterpenoids, alkaloids, flavonoids, essential oils, and other compounds. Among them, sesquiterpenoids, flavonoids, and alkaloids are assessed as representative active ingredients of L. aggregata. A wide variety of pharmacological effects of L. aggregata, such as anti-hyperlipidemic, anti-tumor, anti-inflammatory, analgesic, and anti-oxidant, have been proved in vitro and in vivo. In summary, this review aims to provide a scientific basis and reference for further research and utilization of L. aggregata and lay the foundation for developing functional foods with potential active ingredients for the prevention and management of related diseases.

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Phytochemicals in the Treatment of Arthritis: Current Knowledge

Cited by 8 publications

References 36 publications

Determination of the Total Antioxidant Activity of Methanolic Extract of Falcaria Vulgaris

Determination of the Total Antioxidant Activity of Methanolic Extract of Falcaria Vulgaris

Antioxidant, Anti-inflammatory, and Anti-arthritic Effect of Thymoquinone-rich Black Cumin (Nigella sativa) oil (BlaQmax®) on Adjuvant-induced Arthritis

A review on the chemical constituents and pharmacological efficacies of Lindera aggregata (Sims) Kosterm

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