The objective of the present review is to evaluate the therapeutic potential of phytochemicals against arthritis, which is asymptomatic disorder of chronic joint inflammation followed by swelling and pain. Here, we discussed about the anti-arthritic activity of many phytomolecules such as Norisoboldine, Berberine, Triptolide, Hesperidin Hesperidin, Madecassocide, Hydroxy napthoquinone, Ginsenoside, Cryptotanshinone, Kirenol, Thymoquinone, Chlorogenic acid, Curcumin, Bromelain, Andrographolide and Allicin. These compounds are able to control inflammatory responses, proinflammatory cytokines, osteoclast differentiation and to prevent bone erosion in the joints. In this article, we reviewed anti-arthritic activities of phytichemicals from 2011-2019, using various scientific websites like PubMed, Google Scholar, Science Direct etc. Till date clinical trials conducted with anti-arthritic phytomolecules are very less. Hence, more clinical trials are needed to bring plant molecules as safe and effective anti-arthritic drugs in the market, either alone or in combination with other anti-arthritic agents.

The science of drug delivery has been increasingly innovative and quick evolving with everincreasing demand in the current scientific scenario. Fast dissolving tablet (FDT) is one of those forms of an advanced and special drug delivery system that is rapidly gaining a lot of attention in the rapid dissolution technology research sector. Fast dissolving tablets appear as one of the common and widely accepted dosage types, particularly for paediatric patients due to incomplete muscle and nervous system development and a form of geriatric patients with Parkinson's disease or hand shivering. The most popular administrative path for different medications has drawbacks such as first-pass metabolism, psychotic patients, bedridden and Uncollaborative patients, is the oral delivery type and oral path FDTs disintegrate or quickly dissolve in the saliva without requiring water. Within few seconds, FDT will dissolve within saliva for approximately 60 seconds and these comprises will dissolve even faster

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A number of advancements have been made in the drug delivery system in order to achieve the goals of improved efficacy and cost-effectiveness in therapy. Controlling the rate of release of active drugs to a predetermined site in the human body has been one of the pharma industry's most challenging tasks. Microsponges are porous cross-linked, non-collapsible microspheres with a size range of 5-300µm that can entrap a variety of drugs and then be incorporated into a formulated product like gel, cream, powder, or liquid. Controlled release of drugs onto the epidermis with the confidence that the drug remains primarily localized and does not enter the systemic circulation in substantial amounts is a field of research that the microsponge delivery system is progressively exploring. In order to remove systemic exposure and minimize local cutaneous reaction to active drugs, microsponge technology has been introduced in topical drug products to facilitate the controlled release of the active drugs into the cell. Also, numerous studies have shown that microsponge systems are non-irritating, non-mutagenic, non-allergenic, and non-toxic. MDDS technology is being used currently in cosmetics, over-the-counter (OTC) skin care, sunscreens, and prescription products and has recently been used in oral drugs as well as biopharmaceuticals (protein, peptides, and DNA based therapeutics) drug delivery. The purpose of this article is to provide information about microsponges such as the method of preparation, mechanism of drug release from microsponges, characterization, applications of microsponges, and information about microsponges updated research.

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