Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers

Cojocneanu, Roxana; Braicu, Cornelia; Ráduly, Lajos; Zănoagă, Oana; Dragoş, Nicolae; Monroig, Paloma del C.; Dumitraşcu, Dan L.; Berindan‐Neagoe, Ioana

doi:10.2147/ott.s83597

Cited by 74 publications

(52 citation statements)

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“…They possess complementary and overlapping mechanisms to slow down the carcinogenic process by scavenging free radicals (Lee et al, 2013), suppressing survival and proliferation of malignant cells (Yan et al, 2018), as well as diminishing invasiveness and angiogenesis of tumors (Lu et al, 2018a). They exert wide and complex range of actions on different molecular targets and signal transduction pathways including membrane receptors (Deng et al, 2017), kinases (Dou et al, 2018), downstream tumor-activator or -suppressor proteins (Adams et al, 2010), transcriptional factors (Zhang et al, 2017b), microRNAs (miRNAs) (Cojocneanu et al, 2015), cyclins, and caspases (Yan et al, 2018).…”

Section: Phytochemicals With Anticancer Propertiesmentioning

confidence: 99%

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

et al. 2020

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Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer progression has led to the development of a vast number of anticancer drugs. However, the use of chemically synthesized drugs has not significantly improved the overall survival rate over the past few decades. As a result, new strategies and novel chemoprevention agents are needed to complement current cancer therapies to improve efficiency. Naturally occurring compounds from plants known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, and podophyllotoxin analogs. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancer. The specific mechanisms include increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, induction of cell cycle arrest and apoptosis; and regulation of the immune system. The primary objective of this review is to describe what we know to date of the active compounds in the natural products, along with their pharmacologic action and molecular or specific targets. Recent trends and gaps in phytochemical based anticancer drug discovery are also explored. The authors wish to expand the phytochemical research area not only for their scientific soundness but also for their potential druggability. Hence, the emphasis is given to information about anticancer phytochemicals which are evaluated at preclinical and clinical level.

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Section: Phytochemicals With Anticancer Propertiesmentioning

confidence: 99%

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

et al. 2020

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“…These evidences are supported by epidemiological studies [5,6,7]. The benefits of natural products are also underlined by the so-called “Asian paradox”.…”

Section: Introductionmentioning

confidence: 85%

“…Phytochemicals were demonstrated to be able to modify miRNA expression pattern and their mRNA targets, leading to the alteration of different processes involved in cancer (apoptosis cell proliferation and differentiation, angiogenesis, metastasis, and assimilation of drug resistance in cancer [6,118,120,126,127]. The let-7 family of miRNA is listed as one of the key families involved in cancer, where increased expression of this sequences can exercise a decreasing role on tumour growth [128,129,130,131,132,133].…”

Section: Dietary Phytochemicals As Non-coding Genes Regulatorsmentioning

confidence: 99%

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Budişan

Gulei

Zănoagă

et al. 2017

IJMS

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Phytochemicals are natural compounds synthesized as secondary metabolites in plants, representing an important source of molecules with a wide range of therapeutic applications. These natural agents are important regulators of key pathological processes/conditions, including cancer, as they are able to modulate the expression of coding and non-coding transcripts with an oncogenic or tumour suppressor role. These natural agents are currently exploited for the development of therapeutic strategies alone or in tandem with conventional treatments for cancer. The aim of this paper is to review the recent studies regarding the role of these natural phytochemicals in different processes related to cancer inhibition, including apoptosis activation, angiogenesis and metastasis suppression. From the large palette of phytochemicals we selected epigallocatechin gallate (EGCG), caffeic acid phenethyl ester (CAPE), genistein, morin and kaempferol, due to their increased activity in modulating multiple coding and non-coding genes, targeting the main hallmarks of cancer.

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“…Para exercer sua atividade carcinogênica, o DMBA precisa ser metabolicamente ativado através de enzimas do citocromo P450. Mais especificamente, a enzima CYP1A é responsável por sua ativação no fígado, enquanto a CYP1B é responsável por sua ativação em outros órgãos, como na glândula mamária (CHRISTOU et al, 1995;LAMBARD et al, 1991 (PETRIC et al, 2015;LAMARTINIERE et al, 1995;SIERI et al, 2008;WITTE;HARDMAN, 2015).…”

Section: Dmba Como Modelo De Estudo Do Câncer De Mamaunclassified

“…O tratamento de células de câncer de mama, com a epigalocatequina-3-galato, composto fenólico presente no chá verde, resultou em diminuição na proliferação celular pela interrupção do ciclo celular na fase G1, através da inibição das ciclinas D e E (THANGAPAZHAM et al, 2007). Esse composto ainda apresenta propriedades antioxidativas e de promoção de apoptose, também responsáveis por seu potencial quimiopreventivo (PETRIC et al, 2015). O alto consumo de fibras na dieta estaria relacionado à diminuição no risco de câncer de mama tanto em estudos epidemiológicos (AUNE et al, 2012;PARK et al, 2009), como em modelos animais (COHEN et al, 1991).…”

Section: Dmba Como Modelo De Estudo Do Câncer De Mamaunclassified

Influência da deficiência ou suplementação com selênio durante o período gestacional de ratas na suscetibilidade da progênie feminina à carcinogênese mamária

Rosim¹

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Based on epidemiological studies and animal models, the essential micronutrient selenium has been highlighted as a promising dietary factor associated to breast cancer risk reduction. Breast cancer may have its origin in early development and thus the maternal diet could have important implications in the fetal programming of the disease. In order to ascertain whether differences in selenium concentration in maternal diet could modulate the susceptibility of female offspring to breast cancer, a biological assay was conducted in which female rats were fed a diet with 0.15 (CO), 1.0 (SUP) or 0.05 (DEF) ppm of selenium during gestational period and the female offspring subjected to a mammary carcinogenesis model induced by DMBA. SUP group offspring presented decreased susceptibility to mammary carcinogenesis, as indicated by lower (p< 0,05) average number and multiplicity od adenocarcinomas, while the DEF group offspring had a greater susceptibility, as indicated by the increase (p< 0,05) in adenocarcinomas incidency. Mothers of the DEF group pesented lower (p< 0,05) Se blood concetrations and their offspring presented lower (p<0,05).GPx1 activity.In addition, there was a decrease (p< 0,05) in ER, Her-2, EGFR and Ras expression (western blot and qPCR) in the mammary gland of 7 weeks old female SUP group offspring when compared to CO and DEF groups offspring. DNA global methylation pattern (HPLC-DAD), DNMT1, 3a e 3b expression (qPCR), global pattern of post-translational modification in histones (western blot) and methylation status of Er promoter region (bisulfite modification and pyrosequencing) were also evaluated in the mammary gland of 7 weeks old offspring. There was no diffrence (p>0,05) in DNA global methylation pattern and DNMTs expression. There was an increase in acetilated H4K16 expression in groups SUP and DEF (p< 0,05). Lastly, when compared to DEF offspring, the SUP offspring presented a marginal increase in the methylation of two CpG dinucleotides in the Er promoter region. In conclusion, the consumption of different selenium concentration in maternal diet plays a role in the progeny's breast cancer susceptibility through the modulation of receptors and oncogenes expression, in addition to modifications in epigenetic patterns. These results indicate the presence of a "programming window" in the beggining of development susceptible to selenium effects, resulting in decreased breast cancer risk when supplemented and the opposite when deficient.

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Phytochemicals modulate carcinogenic signaling pathways in breast and hormone-related cancers

Cited by 74 publications

References 115 publications

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Dietary Intervention by Phytochemicals and Their Role in Modulating Coding and Non-Coding Genes in Cancer

Influência da deficiência ou suplementação com selênio durante o período gestacional de ratas na suscetibilidade da progênie feminina à carcinogênese mamária

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