Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

Chauhan, Akansha; Islam, Asimul; Prakash, Hridayesh; Singh, Sandhya

doi:10.1016/j.jpha.2021.07.002

Cited by 78 publications

(47 citation statements)

References 113 publications

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“…Ginger ethanol extract pre-applied to the skin of Sensitivity to carcinogenesis mice model significantly inhibited tissue plasminogen activator (TPA)-induced cyclooxygenase and lipoxygenase activities, ODC mRNA expression, and epidermal edema and hyperplasia (Katiyar, et al, 1996). Research has established that gingerol is able to scavenge the peroxyl radicals produced during pulse radiolysis (Park et al, 1998;Ahmad et al, 2001;Chauhan et al, 2021). 6-gingerol inhibits tumor growth and metastasis through the inhibition of cyclooxygenase-2 (COX-2) and the p38 MAPK-NF-κB pathway (mitogen-activated protein kinase-necrosis factor-kappa B) (Kim et al, 2005a;Kim et al, 2005b).…”

Section: Anticancer Agentmentioning

confidence: 99%

Ginger–a potential source of therapeutic and pharmaceutical compounds

Verma¹,

Bisen²

2022

Journal of Food Bioactives

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Ginger is traditionally known for its therapeutic and pharmaceutical properties. It has been used widely to treat various health problems such as high blood pressure, coughs, colds, swelling, nausea, rheumatic disorders, vomiting, bronchitis, indigestion, gastric ulcers, and behavioral problems. Shogaol and Gingerol are anti-inflammatory, anti-fever, anti-pain, and anti-cough compounds that may help treat a cold. This review provides an up-to-date understanding of the impact of ginger and its active compounds on human health. Various ginger compounds such as gingerol, shogaols, zingiberene, zingerone, paradols and zingerone are receiving attention for their clinical applications and pharmaceutical properties. Studies indicate that ginger is anti-inflammatory, anti-tumor, antimicrobial, antiemetic, hepatoprotective, and neuroprotective. During the inflammatory response, ginger inhibits (NF-κB) and immune system activation in addition to many other cellular processes. Ginger has shown benefits in preclinical and clinical studies for neurology, cardiovascular disease, and cancer. These findings indicate the necessity for further in vivo and clinical studies.

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Section: Anticancer Agentmentioning

confidence: 99%

Ginger–a potential source of therapeutic and pharmaceutical compounds

Verma¹,

Bisen²

2022

Journal of Food Bioactives

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“…NF-kB is the only signaling molecule which governs both pro- and anti-inflammatory, and pro- and anti-apoptotic responses, because of the canonical and non-canonical parts of the NF-kB signaling pathway. Altogether, these pathways regulate cancer-related inflammation, neoplasia, hyperplasia, and metastasis [ 86 ]. NF-kB overexpression induces cell proliferation, and it has been reported in various cancers, including breast and pancreatic cancer, multiple myeloma, head and neck squamous cell carcinoma, and melanoma [ 87 ].…”

Section: Signaling Molecules and Biological Pathways Targeted By Plan...mentioning

confidence: 99%

“…Lycopene is another carotenoid, extremely potent as an antioxidant, that exhibits anti-proliferative and anticancer properties. Lycopene and β-carotene inhibited the IκB phosphorylation, NF-kB transcriptional activity, and suppressed the TNF-induced nuclear translocation of the p65 subunit in vitro [ 86 , 90 , 91 ].…”

Section: Signaling Molecules and Biological Pathways Targeted By Plan...mentioning

confidence: 99%

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy

Sevastre

Manea

Popescu

et al. 2022

IJMS

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Despite the great advancements made in cancer treatment, there are still many unsatisfied aspects, such as the wide palette of side effects and the drug resistance. There is an obvious increasing scientific attention towards nature and what it can offer the human race. Natural products can be used to treat many diseases, of which some plant products are currently used to treat cancer. Plants produce secondary metabolites for their signaling mechanisms and natural defense. A variety of plant-derived products have shown promising anticancer properties in vitro and in vivo. Rather than recreating the natural production environment, ongoing studies are currently setting various strategies to significantly manipulate the quantity of anticancer molecules in plants. This review focuses on the recently studied secondary metabolite agents that have shown promising anticancer activity, outlining their potential mechanisms of action and pathways.

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“…Emerging evidence has shown the influence of chemoresistance on cancer therapy (5,14,15). Although phytochemicals have exhibited critical regulatory roles in the modulation of TLR, NF-kB, and NLRP in combating cancer (16)(17)(18), there is no review report on the potential of phytochemicals in targeting TLR/NF-kB/NLRP pathway and pivotally interconnected pathways during chemoresistance. Thus, there is an imperative need to discover the precise dysregulated pathways involved in chemoresistance as well as to develop new strategies and alternative therapies to combat cancer chemoresistance.…”

Section: Introductionmentioning

confidence: 99%

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

et al. 2022

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BackgroundTumors often progress to a more aggressive phenotype to resist drugs. Multiple dysregulated pathways are behind this tumor behavior which is known as cancer chemoresistance. Thus, there is an emerging need to discover pivotal signaling pathways involved in the resistance to chemotherapeutic agents and cancer immunotherapy. Reports indicate the critical role of the toll-like receptor (TLR)/nuclear factor-κB (NF-κB)/Nod-like receptor pyrin domain-containing (NLRP) pathway in cancer initiation, progression, and development. Therefore, targeting TLR/NF-κB/NLRP signaling is a promising strategy to augment cancer chemotherapy and immunotherapy and to combat chemoresistance. Considering the potential of phytochemicals in the regulation of multiple dysregulated pathways during cancer initiation, promotion, and progression, such compounds could be suitable candidates against cancer chemoresistance.ObjectivesThis is the first comprehensive and systematic review regarding the role of phytochemicals in the mitigation of chemoresistance by regulating the TLR/NF-κB/NLRP signaling pathway in chemotherapy and immunotherapy.MethodsA comprehensive and systematic review was designed based on Web of Science, PubMed, Scopus, and Cochrane electronic databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were followed to include papers on TLR/NF-κB/NLRP and chemotherapy/immunotherapy/chemoresistance by phytochemicals.ResultsPhytochemicals are promising multi-targeting candidates against the TLR/NF-κB/NLRP signaling pathway and interconnected mediators. Employing phenolic compounds, alkaloids, terpenoids, and sulfur compounds could be a promising strategy for managing cancer chemoresistance through the modulation of the TLR/NF-κB/NLRP signaling pathway. Novel delivery systems of phytochemicals in cancer chemotherapy/immunotherapy are also highlighted.ConclusionTargeting TLR/NF-κB/NLRP signaling with bioactive phytocompounds reverses chemoresistance and improves the outcome for chemotherapy and immunotherapy in both preclinical and clinical stages.

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Phytochemicals targeting NF-κB signaling: Potential anti-cancer interventions

Cited by 78 publications

References 113 publications

Ginger–a potential source of therapeutic and pharmaceutical compounds

Ginger–a potential source of therapeutic and pharmaceutical compounds

Intracellular Pathways and Mechanisms of Colored Secondary Metabolites in Cancer Therapy

Modulation of TLR/NF-κB/NLRP Signaling by Bioactive Phytocompounds: A Promising Strategy to Augment Cancer Chemotherapy and Immunotherapy

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