Phytochemistry and bioactivity of aromatic and medicinal plants from the genus Agastache (Lamiaceae)

Abstract

Agastache is a small genus of Lamiaceae, comprising 22 species of perennial aromatic medicinal herbs. In this article, we review recent advances in phytochemical, pharmacological, biotechnological and molecular research on Agastache. The phytochemical profile of all Agastache species studied to date is generally similar, consisted of two main metabolic classes—phenylpropanoids and terpenoids. In the relatively variable essential oils, most populations of different Agastache species contain over 50 % of a phenylallyl compound—estragole. Also, other volatile compounds (methyleugenol, pulegone, menthone, isomenthone and spathulenol) were reported in various proportions. Major non-volatile metabolites belong to phenolic compounds, such as caffeic acid derivatives, especially rosmarinic acid as well as several flavones and flavone glycosides like acacetin, tilianin, agastachoside, and a rare dimeric malonyl flavone (agastachin). Two unique lignans—agastenol and agastinol—were also isolated. Terpenoids include triterpenoids of oleanane-type (maslinic acid, oleanolic acid and β-amyrin), ursane-type (ursolic acid, corosolic acid and α-amyrin), and typical plant sterols, as well as abietane-type oxidized diterpenes (e.g., agastaquinone, agastol, and others). The bioactivity of various extracts or individual compounds in vitro and in vivo include antimicrobial, antiviral and anti-mutagenic activity, cytotoxic activity to cancer cell lines, and anti-nociceptive, anti-inflammatory, anti-atherogenic, antioxidant as well as biocidal activity to several foodstuff pests. Biotechnological and molecular studies have focused on in vitro propagation and enhancing the biosynthesis of bioactive metabolites in cell or organ cultures, as well as on the expression of genes involved in phenolic biosynthesis.

Response of Different <i>Agrobacterium Rhizogenes</i> Strains for <i>in vitro</i> Hairy Root Induction and Accumulation of Rosmarinic Acid Production in <i>Agastache Rugosa</i>

“…The ornamental plant Agastache rugosa (family Lamiaceae), also known as Korean mint, is mainly found in Eastern Asia and is widespread in Korea, Japan and China as reported by (Kang et al, 2013;Zielińska and Matkowski, 2014). In recent years, A. rugosa has become one of the species of choice for medical research due to its interesting physiological and pharmacological properties (Wilson et al, 1992;Song et al, 2001;Shin and Kang, 2003;Jun et al, 2010) and also have anti-inflammatory and anti-a the rogenic properties (Min et al, 1999).…”

Chemical composition of essential oils isolated from Mexican giant hyssop [Agastache mexicana (Kunth.) Link. & Epling.] via hydrodistillation in Deryng and Clevenger apparatuses

“…Recent studies have confirmed pharmacological activity of Mexican giant hyssop towards blood vessels and its antioxidant and anti-inflammatory properties [Ibarra-Alvadaro et al 2010, Gonzalez-Ramirez et al 2012. As a typical genus of Lamiaceae family, Agastache plants are rich in biologically active substances, such as phenylpropanoids (flavonoids, free phenolic acids, lignans, polyphenols) or terpenoids [Svoboda et al 1995, SuchorskaTropiło and Pióro-Jabrucka 2004, Zielińska and Matkowski 2014.…”

Chemo-type of essential oil of Ocimum basilicum L. from DR Congo and relative in vitro antioxidant potential to the polarity of crude extracts

“…As a result extraction, characterization and the use of natural antioxidants from plants have been known to be a great progress [10][11][12]. Various aromatic plants' parts and volatile oil of the Lamiaceae family have been reported to be rich in polyphenolic compounds with other secondary metabolites and many of them are known for antioxidant and other medicinal properties [13][14][15]. Lately, our research team carried out researches of medicinal plants for the management of sickle cell disease and more than 115 plants have been tested [16][17][18][19][20][21][22].…”