Phytochemistry and biological activities of Aglaia species

Harneti, Desi; Supratman, Unang

doi:10.1016/j.phytochem.2020.112540

Cited by 36 publications

(39 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mass spectra were obtained with Waters Q-TOF Xevo mass spectrometer instrument. The NMR spectra were recorded on the JEOL JNM-ECX500R/S1 spectrometer at 500 MHz for 1 H and 125 MHz for 13 C with TMS as an internal standard. The column chromatography was performed on silica gel 60 (Merck, 70-230 and 230-400 mesh) and octadecyl silane (Fuji Sylisia, 200-400 mesh).…”

Section: Instrumentationmentioning

confidence: 99%

“…The Aglaia genus has been identified in Southern Asia's tropical and subtropical rainforest, Northern Australia, and the pacific region. The distributions of the Aglaia genus can be found in many countries, such as India, Thailand, Vietnam, Malaysia, and Indonesia [13][14]. Traditionally, the bark of Aglaia has been used as traditional Indonesian herbal medicine for healing fever, influenza, cough, and other skin diseases [3,[13][14].…”

Section: ■ Introductionmentioning

confidence: 99%

“…simplicifolia is one of Aglaia plants that has been phytochemically investigated before, and it has been proven to contain ergosterol peroxide, stigmasterol, and senecrassidiol with cytotoxic activity against HeLa cervical cancer [15][16]. So far, about twenty-three sesquiterpenoids have been investigated separately from the Aglaia species [13]. Therefore, to observe the cytotoxic constituents of Indonesian Aglaia plants against B16-F10 melanoma skin cancer cell lines, we report herein the isolation, structure elucidation, and cytotoxic evaluation of four types of aromadendrane, caryolan, clovane, and caryophyllene sesquiterpenoids 1-4 from A. simplicifolia.…”

Section: ■ Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

et al. 2021

Self Cite

View full text Add to dashboard Cite

Four sesquiterpenoid derivatives, i.e., 4β,10α-dihydroxyaromadendrane (1), caryophyllenol-II (2), senecrassidiol (3), and clovane-2β,9α-diol (4) have been isolated from the stem bark of Aglaia simplicifolia. The chemical structures of compounds 1-4 were determined based on spectroscopic data, including one and two-dimensional NMR and mass spectroscopy. In addition, these sesquiterpenoids 1-4, were also tested for their cytotoxic activity against B16-F10 melanoma skin cancer cell lines through in vitro assay. Among the isolated compounds 1-4, compound 1 showed the highest activity with an IC50 value of 44.8 μg/mL, suggesting the presence of a cyclopropane ring that plays an essential role in cytotoxic activity against B16-F10 melanoma skin cancer cell lines.

show abstract

Section: Instrumentationmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Aglaia is the largest genus belongs to the Meliaceae family contains more than 150 species (Hidayat et al, 2017a;Hidayat et al, 2017b;Awang et al, 2012) and about 65 species grown in Indonesia (Wood, et al, 1970;Heyne 1982). Phytochemical studies on Aglaia species have led to the identification of main compounds such as sesquiterpenoid, diterpenoid, triterpenoid, limonoid, steroid, lignan, and alkaloid groups (Harneti & Supratman, 2021).…”

Section: Introductionmentioning

confidence: 99%

Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Kurniasih¹,

Supriadin²,

Harneti³

et al. 2021

Valensi

Self Cite

View full text Add to dashboard Cite

Two steroid compounds, ergosterol peroxide (1) and stigmasterol (2) have been isolated from the stembark of Aglaia simplicifolia belong to Meliaceae family. The chemical structures of 1 and 2 were identified based on spectroscopic evidence including UV, IR, 1D NMR, 2D NMR as well as mass spectra and by comparison with those previously reported spectra data. Both compounds were evaluated for their cytotoxic effects against cervical cancer HeLa cells in vitro. Compounds 1 and 2 showed cytotoxicity activity against HeLa cervical cancer cells with IC50 values of 0.80 and 26.42 µM, respectively.

show abstract

“…Structures of cytotoxic rocaglates isolated from various Aglaia species and several related synthetic congeners(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27).…”

mentioning

confidence: 99%

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

et al. 2021

View full text Add to dashboard Cite

With about 120 species, Aglaia is one of the largest genera of the plant family Meliaceae (the mahogany plants). It is native to the tropical rainforests of the Indo-Australian region, ranging from India and Sri Lanka eastward to Polynesia and Micronesia. Various Aglaia species have been investigated since the 1960s for their phytochemical constituents and biological properties, with the cyclopenta[b]benzofurans (rocaglates or flavaglines) being of particular interest. Phytochemists, medicinal chemists, and biologists have conducted extensive research in establishing these secondary metabolites as potential lead compounds with antineoplastic and antiviral effects, among others. The varied biological properties of rocaglates can be attributed to their unusual structures and their ability to act as inhibitors of the eukaryotic translation initiation factor 4A (eIF4A), affecting protein translation. The present review provides an update on the recently reported phytochemical constituents of Aglaia species, focusing on rocaglate derivatives. Furthermore, laboratory work performed on investigating the biological activities of these chemical constituents is also covered.

show abstract

Phytochemistry and biological activities of Aglaia species

Cited by 36 publications

References 82 publications

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

Sesquiterpenoids from the Stem Bark of <i>Aglaia simplicifolia</i> and Their Cytotoxic Activity against B16-F10 Melanoma Skin Cancer Cell

Ergosterol Peroxide and Stigmasterol from The Stembark of Aglaia simplicifolia (Meliaceae) and Their Cytotoxic against HeLa Cervical Cancer Cell Lines

Update on Phytochemical and Biological Studies on Rocaglate Derivatives from Aglaia Species

Contact Info

Product

Resources

About