Phytochemistry and pharmacological activities of the genus Prunella

Bai, Yubing; Xia, Bo‐Hou; Xie, Wen-Jian; Zhou, Yamin; Xie, Jiachi; Li, Hongquan; Liao, Duan‐Fang; Lin, Limei; Li, Chun

doi:10.1016/j.foodchem.2016.02.047

Cited by 94 publications

(80 citation statements)

References 101 publications

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“…pyrenaicum , contain rosmarinic acid, oleanolic acid, ursolic acid, betulinic acid, rutin, caffeic acid, chlorogenic acid and ferulic acid. [ ][ ][ ] The amounts or rosmarinic, ursolic and oleanolic acid vary considerably depending on the species of the Lamiaceae family. [ ][ ] Rosmarinic acid is the chemotaxonomical marker of the subfamily Nepetoidae .…”

Section: Discussionmentioning

confidence: 99%

Phytochemical Profiles of Alpine Plant Horminum pyrenaicum L. during Phenological Growth Stages

Raudonė

Motiekaitytė

Vainorienė

et al. 2018

Chemistry & Biodiversity

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Horminum pyrenaicum L. is a medicinal, aromatic and ornamental plant native to the Pyrenees and Alps. The phytochemical composition is affected by various ecological factors, climatic conditions and cultivating factors, and especially phenological growth stages. Flavonoids, phenolic acids and triterpenic acids were identified and quantified in the above-ground parts of H. pyrenaicum during the phenological stages. The massive flowering was distinguished with the greatest total amounts of phenolic compounds (22232.8 μg/g), and rosmarinic acid was the predominant compound. The amounts of triterpenic compounds were at the lowest during the intense growth stage and significantly increased up to the massive flowering. The prevailing compounds were ursolic acid and betulinic acid, 12092.4 μg/g and 2618.9 μg/g, respectively. The major essential oil compounds were β-phellandrene (56.6%), caryophyllene oxide (5.9%), (Z)-caryophyllene (4.4%), myrcene (4.1%) and thymol (3.6%). Selecting the optimal harvesting time could ensure the herbal raw material rich with preferred bioactive compounds.

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Section: Discussionmentioning

confidence: 99%

Phytochemical Profiles of Alpine Plant Horminum pyrenaicum L. during Phenological Growth Stages

Raudonė

Motiekaitytė

Vainorienė

et al. 2018

Chemistry & Biodiversity

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“…The dried spikes of Prunella vulgaris have been used as traditional medicines and food ingredients for > 100 years in East Asian, European, and American countries, and it is also a major component of famous herbal teas (Wong Lo Kat®) [13,14]. This plant has antiviral, antibacterial, anti-in ammatory, antitumor, and blood pressure-modulating effects [13,[15][16][17][18]. Phytochemical studies isolated triterpenoids [18][19][20], phenolic acids [21,22], polysaccharides [23,24], and avonoids [13] from P. vulgaris.…”

Section: Introductionmentioning

confidence: 99%

A fraction of Prunella vulgaris spike extract inhibited neutrophil elastase and protected mice against lipopolysaccharide-induced acute lung injury

Cheng

Chong

et al. 2020

Preprint

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Background Human neutrophil elastase (HNE) is an abundantly expressed neutrophil serine protease that promotes neutrophil invasion and neutrophil extracellular trap (NET) formation, thereby mediating lung tissue destruction and enhancing pulmonary inflammation in acute lung injury (ALI). Chemical agents that target HNE and manipulate HNE level homeostasis are desired to prevent or treat ALI. Methods In a search for HNE inhibitors, traditional Chinese medicines were evaluated, leading to the identification of the water extract of spikes of Prunella vulgaris as an inhibitor of HNE activity. Using bioactivity-guided fractionation, a bioactive fraction (PVAP) that inhibited NHE activity was prepared, and its effects on lipopolysaccharide (LPS)-induced ALI were studied. Results The results suggested that PVAP elicited protective effects against LPS-induced ALI by inhibiting HNE activity, thereby reducing neutrophil invasion, pro-inflammatory cytokine release, and NET formation. Conclusions These findings illustrated the utility of PVAP as an agent for preventing ALI.

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“…Flavonoids, widely distributed in plants, such as fruits, vegetables, and soybeans, provide health benefits via anti-inflammatory and antioxidant actions: flavonoids exhibit anti-inflammatory action by inhibiting both the activity and production of various inflammatory enzymes, such as tumor necrosis factor ␣ (TNF-␣), 1 cyclooxygenase, 1 and lipoxygenase, 2,3 and antioxidant action through activation of antioxidant enzymes, such as catalase, glutathione peroxidase, 4 and heme oxygenase-1 (HO-1), 5 which show radical scavenging ability. 4,6 Further studies indicate that flavonoids regulate ion transporters and channels, 7,8 which control ion environments and play important roles in the maintenance of various body and cellular functions (e.g., blood pressure dependent on blood volume via reg-ulation of activity and expression of the epithelial Na + channel (ENaC) 9,10 and the interstitial pHdependent insulin sensitivity in the control of blood sugar level [11][12][13][14][15] ). Quercetin, a flavonoid, induces elevation of the cytosolic Clconcentration ([Cl -] c ) 16 via activation of Na + -K + -2Clcotransporter 1 (NKCC1).…”

Section: Introductionmentioning

confidence: 99%

Actions of quercetin, a flavonoid, on ion transporters: its physiological roles

Marunaka

2017

Annals of the New York Academy of Sciences

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Flavonoids keep us healthy by controlling various body and cellular functions. It is well known that cations, such as Na , K , and Ca , play important roles in the regulation of body and cellular functions, including generation of action potentials and the resting membrane potential of neural and muscle cells and signal transduction as intracellular second messengers. However, we have little information on the physiological roles of anions, particularly Cl , in body and cellular functions. Quercetin, a flavonoid, stimulates Na -K -2Cl cotransporter 1 (NKCC1), which is one of the most important ion transporters regulating the cytosolic Cl concentration ([Cl ] ). Here, we introduce the molecular mechanism by which flavonoids, specifically quercetin, act through elevation of [Cl ] via activation of NKCC1 on important factors controlling various body and cellular functions, such as (1) antihypertensive actions controlling blood volume dependent on the amounts of renal Na reabsorption via expression of the epithelial Na channel, (2) neurite-elongating actions via polymerization of tubulin by inhibiting GTPase activity, and (3) antibacterial and antiviral infective actions through stimulation of epithelial Cl secretion by increasing the driving force for epithelial Cl secretion.

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Phytochemistry and pharmacological activities of the genus Prunella

Cited by 94 publications

References 101 publications

Phytochemical Profiles of Alpine Plant Horminum pyrenaicum L. during Phenological Growth Stages

Phytochemical Profiles of Alpine Plant Horminum pyrenaicum L. during Phenological Growth Stages

A fraction of Prunella vulgaris spike extract inhibited neutrophil elastase and protected mice against lipopolysaccharide-induced acute lung injury

Actions of quercetin, a flavonoid, on ion transporters: its physiological roles

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