Phytochemistry and Pharmacological Activities of Swietenia macrophylla King (Meliaceae)

Telrandhe, Umesh B.; Kosalge, Satish B.; Parihar, Shweta; Sharma, Deepti; Lade, Swati N.

doi:10.36347/sajp.2022.v11i01.002

Cited by 11 publications

(6 citation statements)

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“…8 Phenols and flavonoids have been widely reported to have antioxidant activity in both in vivo and in vitro studies. 5 The results of a systematic review show that the phytochemical content of S. macrophylla seeds is mostly tannins, alkaloids, saponins, terpenoids, and stigmasterol. 10 A study on the determination of the phytochemical content of S. macrophylla seeds revealed a high concentration of phenolics (46.22 mg), flavonoids (26.12 mg), and tannins (9.23 mg).…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

2024

TJNPR

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The prevalence of Gestational Diabetes Mellitus (GDM) has increased worldwide alongside an increase in the prevalence of type 2 diabetes mellitus (T2DM). Indonesia is endowed with a rich biodiversity and medicinal plants, including mahogany. Mahogany seeds contain flavonoids, saponins, and limonoids. Limonoid compounds have been shown to inhibit the production of reactive oxygen species (ROS) through the activation of antioxidant enzymes. This study focuses on a systematic review of the potential of the seeds of Swietenia spp. as an antioxidant in GDM. A systematic literature review of 13 scientific articles comprising 12 original research articles and 1 review article published within the last 7-8 years from various scientific databases was conducted. The original research articles were categorized into in vivo and in vitro studies with respect to the antioxidant activity of Swietenia spp. seeds. The systematic review provided a comprehensive understanding of the potential of mahogany seeds as an antioxidant and its role in the management of GDM.

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Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

2024

TJNPR

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“…There are similarities in the phytochemistry of these two Swietenia species. Phytochemical studies have revealed that the primary bioactive compounds in Swietenia seeds are limonoids, specifically swietenine and its derivatives [14,20,30,47]. Limonoids are triterpene derivatives that have lost of four carbon atoms, so the side chain becomes a furan ring [30].…”

Section: Phytochemistry Of Swietenia Seeds With Antidiabetic Activitymentioning

confidence: 99%

The role of Swietenia seed extract in ameliorating blood glucose level for potential treatment of gestational diabetes mellitus: A literature review

Husnul Khotimah,

Savira Oktavia Ainiyati,

Ayu Mei Wulandari

et al. 2024

World J. Adv. Res. Rev.

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Gestational diabetes mellitus (GDM) can be defined as glucose intolerance identified for the first time during pregnancy. The number of diabetes occur in pregnancy about 1 of 10 cases, but the use of pharmacological drug needs to be considered. So, there is non-pharmacological treatment for alternative such as of using mahogany seeds that have potential hypoglycemia activity. The aim of this study to provide a comprehensive understanding the roles of Swietenia seeds extract in ameliorating blood glucose level for potential treatment of gestational diabetes mellitus condition. This study uses a systematic literature Review based on PRISMA-P. To identify the analyzed literature, we used five databases [including Google Scholar, PubMed, ProQuest, Science direct, and Springer] with relevant keywords using Boolean. Selected articles should discuss about mahogany seeds (Swietenia macrophylla and Swietenia mahogany) as an antidiabetic candidate. The search from 5 databases yielded 12 eligible articles to analyze. 7 articles discuss about Swietenia macrophylla King and 5 articles about Swietenia mahogani (L.) Jacq that related as an antidiabetic effect. Both of Swietenia macrophylla and Swietenia mahogani have potential role as antidiabetic agent to reduce blood glucose level and can be potential treatment option in patients with GDM.

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“…One such potential source is broadleaf mahogany (Swietenia macrophylla), abundantly found in Indonesia. Its seeds contain a plethora of compounds including limonoids, fatty acids, and steroids (Telrandhe et al, 2022). Traditionally, mahogany seeds have been utilized in treating conditions such as high blood pressure, diabetes, and infections.…”

Section: Introductionmentioning

confidence: 99%

Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study

Cahya,

Nurlela,

Tohir

et al. 2024

J Jamu Indo

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Breast cancer is a leading cause of cancer-related deaths in Indonesia. However, the drugs that are commonly used for treatment can cause side effects and become resistant over time. A study was conducted to test the cytotoxic activity of broadleaf mahogany (Swietenia macrophylla) seed extract on MCF-7 breast cancer cells in vitro. The study aimed to predict active compounds in the broadleaf mahogany seeds that have the potential to act as anti-breast cancer agents using in silico analysis. Molecular docking, visualization of the interaction between the receptor and the ligands, and physicochemical analysis were used to determine the most promising compounds. The receptors used were fibroblast growth factor receptor 1 (FGFR1), vascular endothelial growth factor receptor 2 (VEGFR2), insulin-like growth factor type 1 receptor (IGF-1R), estrogen receptor (ER-α), and progesterone receptor (PR). The results showed that 12 compounds have the potential to be active as anti-breast cancer agents. Three of these compounds, 3β,6-dihydroxydihydrocarapine, stigmasterol, and 7-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-chroman-4-one, were predicted to have similar mechanisms of inhibition as a comparator drug based on binding site similarity values. These compounds are predicted to be taken orally and are promising for further research.

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Phytochemistry and Pharmacological Activities of Swietenia macrophylla King (Meliaceae)

Cited by 11 publications

References 0 publications

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

A Systematic Review on the Hypoglycemic Potentials of Mahogany (Swietenia spp.) Seeds as Antioxidants in the Management of Gestational Diabetes Mellitus

The role of Swietenia seed extract in ameliorating blood glucose level for potential treatment of gestational diabetes mellitus: A literature review

Potential of Active Compounds in Broadleaf Mahogany (Swietenia macrophylla) Seeds Against Breast Cancer Cells Based on In Silico Study

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