Phytochemistry and phylogenetic affinities among Egyptian species of Fagonia

Saleh, Nabiel A.M.; El-Hadidi, M.N.; Al-Wakeel, S.A.M.

doi:10.1016/0305-1978(90)90033-c

Cited by 21 publications

(12 citation statements)

References 6 publications

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“…The residue was dissolved in isopropanol and subjected to paper chromatography using ethyl acetate: pyridine: water 12: 5: 4 and benzene: n-butanol: pyridine: water 1: 5: 3: 3 as developing solvents with authentic references from different sugars. The chromatograms were visualized by spraying with aniline phthalate [16,17] and heated at 105ºC for a few minutes, their data were identical to those previously reported [18,19].…”

Section: Complete Acid Hydrolysissupporting

confidence: 73%

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Elhagrasi

Mahmoud

Foda³

et al. 2019

Egypt. J. Chem.

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A LLIUM vegetables have been recorded to be used in many medical remedies for protection and fighting diseases. The aim of the study is to investigate the phenolic compounds of methanol extract of Allium porrum L. aerial parts (MEAP) and introduce the methanolic extract as a candidate for the treatment of cancer in vivo as well as explore its antitumor mechanisms in attacking tumor cells at the molecular level. Isolation of phenolic and flavonoid compounds by column chromatography has been carried out. They were purified by Sephadex LH-20, and the structures were established with the aid of spectroscopic methods (UV, EI/MS, ESI/MS, 1 H-NMR, and 13 C-NMR spectroscopy). A total of 45 female Swiss albino mice were divided into five groups. One group represents the normal control. The four remaining groups were divided as follows: two groups were injected with Ehrlich ascites carcinoma (EAC) cells intraperitoneally and the other two were injected intramuscularly (to form solid tumor), representing the positive nontreated groups. One group from each model was administrated orally the extract at a dose of 300 mg/kg body weight 3 days weekly for 21 days after 24 h from the intraperitoneal or intramuscular injection of EAC cells. The influence of the extract on the apoptotic proteins were tested in EAC cells and in solid tumor of the treated groups compared with the nontreated ones. Eleven phenolic and flavonoid compounds were isolated from the aerial parts of methanol extract of A. porrum L., and characterized as follows: quercetin-3acid, and gallic acid. The gene expressions of caspase-3, Bax, and Bcl2 proteins and DNA fragmentation test were performed in the EAC cells. Hematological profile was conducted on mice's blood in addition to the Immuno-histochemical determination of P53 protein in solid tumors. MEAP has abundant phenolic compounds. It exhibits tumor suppressing mechanisms through the coordination between the apoptic proteins and DNA fragmentation in the EAC or solid cancer cells. MEAP is suggested to be a potent anticancer agent.

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Section: Complete Acid Hydrolysissupporting

confidence: 73%

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Elhagrasi

Mahmoud

Foda³

et al. 2019

Egypt. J. Chem.

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“…Compound 50, luteolin-7-O-β-D-glucopyranoside, has been reported to occur in many plants (Agrawal, 1989). To our knowledge, this is the first flavonoid with luteolin as aglycone isolated from Fagonia genus and Zygophyllaceae family (Saleh et al, 1990;Al-Wakeel, 1992).…”

Section: Chemotaxonomic Significancementioning

confidence: 88%

“…Previous phytochemical studies on Fagonia species demonstrated the presence of flavonoids (Saleh et al, 1990;Al-Wakeel 1992;El-Wakil and Eman, 2007), diterpenoids (Abdel-Kader et al, 1993;Perrone et al 2007;Sallam et al, 2014), sterols glycosides (Shoeb et al 1994), triterpenes (Anjum et al, 2007;Saleem et al, 2014;Farheen et al, 2015) and saponins (Ansari et al, 1988;Miyase et al, 1996a;Melek et al, 2000;Batterjee et al, 2002;Sallam et al, 2014).…”

Section: Previous Workmentioning

confidence: 98%

“…In addition to saponins, the Fagonia species showed remarkably a homogeneous flavonoid profile in which quercetin, kaempferol, isorhamnetin, herbacetin, and herbacetin 8-methyl ether and their glycosides are predominant (Saleh et al, 1990;Abdel-Kader et al, 1993;El-Wakil and Eman, 2007). Compound 50, luteolin-7-O-β-D-glucopyranoside, has been reported to occur in many plants (Agrawal, 1989).…”

Section: Chemotaxonomic Significancementioning

confidence: 99%

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Triterpene saponins from Fagonia scabra Forssk and other Fagonia species

Boutaghane

Kabouche

Voutquenne-Nazabadioko

2016

Biochemical Systematics and Ecology

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“…indica Flavonoids [37] , Triterpenoid Saponins [37,39] , steroidal saponin glycoside [40] , (indicasaponin A) and (indicasaponin B) [41] , and Taraxast-20-en-28-oic acid Saponins [42] . F. Sinaica Boiss flavonol glycosides [43,44] .…”

Section: Phytochemistrymentioning

confidence: 99%

The species of genus fagonia in Libya: (A comprehensive review)

Alamami¹,

Elshibani²,

Elremali³

et al. 2022

J Pharmacogn Phytochem

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The Plants of the genus Fagonia have been broadly utilized as adjunctive therapy, to treat several conditions involving high fever, diabetes, asthma, stoma chache, dental pain, and renal problems using their aqueous extracts as medicines. This genus is a valuable source that comprises a variety of Triterpenes, flavonoids, and Saponins. The herbal chemistry as well as the biological action of Fagonia species have been a candidate for many researchers. The in vivo pharmacological screening of their extracts has manifested some other significant properties such as cytotoxic and anti-cancer activity. This review study has gathered the important research that has been carried out on the species that grow in Libya. It includes an exhaustive survey of literature about the medicinal value and the bioactivities of various extracts obtained from these Fagonia species using references from major databases.

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Phytochemistry and phylogenetic affinities among Egyptian species of Fagonia

Cited by 21 publications

References 6 publications

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Secondary metabolites and Biological activities of Allium porrum L. attack Ehrlich ascites carcinoma in mice

Triterpene saponins from Fagonia scabra Forssk and other Fagonia species

The species of genus fagonia in Libya: (A comprehensive review)

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