Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review

Xue, Bian-Xia; He, Reis; Lai, Jia-Xin; Mireku-Gyimah, Nana Ama; Zhang, Lihua; Wu, Hong‐Hua

doi:10.1007/s11101-023-09870-3

Cited by 14 publications

(4 citation statements)

References 145 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…C. rotundus is a medicinal plant found in tropical and sub-tropical countries including Indonesia, China, India, Korea, Japan, and other countries (Nafisah et al, 2023;Xue et al, 2023). C. rotundus tuber ethanolic extract, specifically obtained from East Java, Indonesia, contained carboxylic acid, carboxylic ester, oligosaccharide, sulfur compound, amino acid, sesquiterpenes, amines, purines, and phenols.…”

Section: Discussionmentioning

confidence: 99%

In silico approach for predicting the bioactive compound of Cyperus rotundus to inhibit NF-kB and iNOS signaling pathways

Setiawan,

Agustini,

Patmawati

et al. 2024

Braz. J. Biol.

View full text Add to dashboard Cite

This study aims to evaluate the anti-cancer-related inflammation activity of Cyperus rotundus bioactive compounds. The component of C. rotundus was analyzed using LC-HRMS. The drug-likeness of all compounds were analyzed using swissADME webserver. In addition, the analysis of inhibition potential of compounds against NF-κB and iNOS were carried out using molecular docking in PyRx software. This study found 1-Nitro-2-phenoxybenzene, ethyl 4-(acetylamino)-3-phenyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate, and nootkatone passed all the parameters of drug-likeness including Lipinski, ghose, veber, egan, and muege. Based on molecular docking, verbascoside A and n-Pentyl isopentyl phthalate has the lowest binding affinity against iNOS (-10 and -8.9 kcal/mol, respectively). In addition, verbascoside A and maltopentaose have binding affinity of -7.6 and -6.6 kcal/mol, respectively, for NF-κB. The anti-cancer activity of verbascoside A, maltopentaose, and n-Pentyl isopentyl phthalate, according to PASS analysis were anti-inflammatory, antineoplastic, chemopreventive, and chemoprotectant. The cytotoxic effect prediction showed that these compounds were relatively selective to kill tumor cell but not non-tumor cell. Rat toxicity analysis showed maltopentaose was non-toxic, where n-Pentyl isopentyl phthalate was only toxic (class IV) for intravenous administration. perMM analysis showed verbascoside A and n-Pentyl isopentyl phthalate can translocate and across the cell membrane.

show abstract

Section: Discussionmentioning

confidence: 99%

In silico approach for predicting the bioactive compound of Cyperus rotundus to inhibit NF-kB and iNOS signaling pathways

Setiawan,

Agustini,

Patmawati

et al. 2024

Braz. J. Biol.

View full text Add to dashboard Cite

show abstract

“…CS is found around rivers, and waterfalls, especially found in damp or marshy regions as well as along coastal areas 16 . CS is widely distributed in the India, Australia, Malesia, China, South Africa, and the Pacific Islands 15 – 18 . The nuts of CS have dietary and medicinal applications.…”

Section: Introductionmentioning

confidence: 99%

“…According to Ayurveda, Nagarmotha rhizomes help improve digestion. Nagarmotha oil is an effective home remedy for managing stomach disorders due to its antispasmodic and carminative properties 15 – 18 . In the Indian Medicinal System, CS rhizomes are known for various biological activities including cordial, tonic, vermifuge, diuretic, diaphoretic, anti-diabetes, hepatoprotective activity, anti-inflammatory, hypotensive, spasmolytic, antioxidant and as a desiccant 19 .…”

Section: Introductionmentioning

confidence: 99%

Chemoprofiling and medicinal potential of underutilized leaves of Cyperus scariosus

Gandhi,

Kumar,

Singh

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Agro-waste is the outcome of the under-utilization of bioresources and a lack of knowledge to re-use this waste in proper ways or a circular economy approach. In the Indian medicinal system, the root of Cyperus scariosus (CS) is used at a large scale due to their vital medicinal properties. Unfortunately, the aerial part of CS is treated as agro-waste and is an under-utilized bioresource. Due to a lack of knowledge, CS is treated as a weed. This present study is the first ever attempt to explore CS leaves as medicinally and a nutrient rich source. To determine the food and nutritional values of the neglected part of Cyperus scariosus R.Br. (CS), i.e. CS leaves, phytochemicals and metal ions of CS were quantified by newly developed HPLC and ICPOES-based methods. The content of the phytochemicals observed in HPLC analysis for caffeic acid, catechin, epicatechin, trans-p-coumaric acid, and trans-ferulic acid was 10.51, 276.15, 279.09, 70.53, and 36.83 µg/g, respectively. In GC–MS/MS analysis, fatty acids including linolenic acid, phytol, palmitic acid, etc. were identified. In ICPOES analysis, the significant content of Na, K, Ca, Cu, Fe, Mg, Mn, and Zn was observed. The TPC and TFC of the CS leaves was 17.933 mg GAE eq./g and 130.767 mg QCE eq./g along with an IC50 value of 2.78 mg/mL in the DPPH assay and better antacid activity was measured than the standard (CaCO3). The methanolic extract of CS leaves showed anti-microbial activity against Staphylococcus aureus (15 ± 2 mm), Pseudomonas aeruginosa (12 ± 2 mm) and Escherichia coli (10 ± 2 mm). In silico studies confirmed the in vitro results obtained from the antioxidant, antiacid, and anti-microbial studies. In addition, in silico studies revealed the anti-cancerous and anti-inflammatory potential of the CS leaves. This study, thus, demonstrated the medicinal significance of the under-utilized part of CS and the conversion of agro-waste into mankind activity as a pharmaceutical potent material. Consequently, the present study highlighted that CS leaves have medicinal importance with good nutritional utility and have a large potential in the pharmaceutical industry along with improving bio-valorization and the environment.

show abstract

“…The components of Chinese herbal medicines are extremely complex, and the extraction and separation of their active antimicrobial ingredients can improve the efficiency of mildew inhibitors [ 13 , 14 , 15 , 16 ]. Some Chinese herbal medicines have identified antimicrobial monomers [ 17 , 18 , 19 ] and determined their chemical structures [ 20 , 21 , 22 , 23 ]. It has been reported that among Chinese herbal antimicrobial substances, phenolic compounds exhibit the strongest antimicrobial activity, followed by aldehydes, alcohols, ketones, esters, and hydrocarbons [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Antimildew Effect of Three Phenolic Compounds and the Efficacy of Antimildew Sliced Bamboo Veneer

Chen

Shan

et al. 2023

Molecules

View full text Add to dashboard Cite

The development of the bamboo industry has been hindered by environmental issues caused by the application of bamboo preservatives. Chinese herbal phenolic compounds have been shown to possess broad-spectrum, potent antimildew properties, making them promising candidates for the development of new bamboo mildew inhibitors. In this study, we investigated the antimildew properties of three phenolic compounds, eugenol, carvacrol, and paeonol, against common mildews in bamboo materials using the Oxford cup method and the double-dilution method. Scanning electron microscopy (SEM) and transmission electron microscopy (TEM) were used to analyze the antimildew mechanism and its effects on mildew cell morphology. Our results showed that carvacrol exhibited the strongest antimildew activity, with minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) values of 1.56 mg/mL and 1.76 mg/mL, respectively, followed by eugenol and paeonol. At a concentration of 25 mg/mL, eugenol and carvacrol had an inhibitory rate of over 50% against various mildews. Different concentrations of the three compounds significantly disrupted the morphology and structural integrity of mildew hyphae, with the extent of damage increasing with concentration and treatment duration. In the sliced bamboo mildew prevention experiment, carvacrol at a concentration of 29.25 mg/mL was found to be highly effective against all tested mildews. Our study provides new insights and a theoretical basis for the development of eco-friendly bamboo mildew inhibitors based on plant phenolic compounds.

show abstract

Phytochemistry, data mining, pharmacology, toxicology and the analytical methods of Cyperus rotundus L. (Cyperaceae): a comprehensive review

Cited by 14 publications

References 145 publications

In silico approach for predicting the bioactive compound of Cyperus rotundus to inhibit NF-kB and iNOS signaling pathways

In silico approach for predicting the bioactive compound of Cyperus rotundus to inhibit NF-kB and iNOS signaling pathways

Chemoprofiling and medicinal potential of underutilized leaves of Cyperus scariosus

Antimildew Effect of Three Phenolic Compounds and the Efficacy of Antimildew Sliced Bamboo Veneer

Contact Info

Product

Resources

About