Phytoconstituents with cytotoxic activity from Ulmus pumila L.

Farouk, R Melek; Soheir, M El Zalabani; Neveen, S Ghaly; Omar, Mustafa; Fayad, Walid; Boulis, Ann G

doi:10.7324/japs.2021.110517

Cited by 2 publications

References 28 publications

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Gram-negative Antimicrobial spectrum of Ulmus pumila

Schafer

Puga

Miller

et al. 2022

Preprint

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Purpose: This study explores the antimicrobial spectrum of Ulmus pumila by screening commonly infectious gram-negative bacteria for susceptibility. Currently, many gram-negative bacteria are developing resistance to recommended antibiotic therapies used in clinical practice. It is imperative that we continue to explore new antimicrobial compounds in order to help combat the global health issue of antibiotic resistance. Method: 3g of freshly harvested leaves and flower samples of Ulmus pumila were extracted in 15 ml of 95% ethanol. The mixture was filtered to remove the debris and sterile blank discs were soaked in the clear filtrate (samples) or the extraction solvent (as background controls) for 20 minutes. Glycerol stocks of bacteria were scaled in LB broth and Muller Hinton agar was prepared with 38g of agar in a liter of water. A 100-microliter suspension of the scaled bacteria was diluted with 9 ml of 1% saline solution and 100 microliters of this saline dilution was plated. Sterile paper discs that were infused with extracts (samples) or vehicle control (95% ethanol) were placed on the freshly plated bacterial plates and incubated at 37 degree Celsius overnight. Zones of inhibition were recorded as a measure of antibacterial activity. Results: Ulmus pumila demonstrated antimicrobial activity against the following gram-negative bacteria: E. coli (16 mm mean zone of clearing), P. vulgaris (15 mm mean zone of clearing), E. cloacae (20.5 mm mean zone of clearing), and K. pneumoniae (16 mm mean zone of clearing). Conclusion: Ulmus pumila displayed antimicrobial activity against various species of gram-negative bacteria including E. coli, P. vulgaris, K. pneumonaie, and E. cloacae. Ulmus pumila has also previously demonstrated activity against some species of gram-positive bacteria. By this discovery, Ulmus pumila has the potential to serve as a broad-spectrum antimicrobial agent with activity against both gram-positive and gram-negative bacteria.

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Gram-negative Antimicrobial spectrum of Ulmus pumila

Schafer

Puga

Miller

et al. 2022

Preprint

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Anti-Inflammatory Screening of Ulmus pumila L ethanolic extract

Sosorburam

Delgermurun

Dorjsuren

2022

Mong. J. Agric. Sci.

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Deciduous trees of Ulmus species were reported to exhibit antibiotic, antifungal, antioxidant, anti-inflammatory, hepatoprotective, neuroprotective, antiangiogenic, and antiviral effects that rich in flavonoids. In this study, phytochemical analysis and pharmacological activities of Ulmus pumila L were studied. The upper parts of Ulmus pumila L plants were grinded and extracted in 80% ethanol with a ratio of 1:10, infusing by maceration method. The total crude extract was fractioned into a group of solvents with increasing polarity: hexane, chloroform, ethyl acetate, and n-butanol. The results of the toxicity test showed the safety of the oral ingestion and treatment with ethanolic and ethyl-acetic fractions decreased inflammatory symptoms and exhibited protective effects for carrageenan-induced paw edema. These preliminary findings may support its traditional medicinal use and could be promising candidate with application in the treatment of inflammatory symptoms.

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Phytoconstituents with cytotoxic activity from Ulmus pumila L.

Cited by 2 publications

References 28 publications

Gram-negative Antimicrobial spectrum of Ulmus pumila

Gram-negative Antimicrobial spectrum of Ulmus pumila

Anti-Inflammatory Screening of Ulmus pumila L ethanolic extract

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