Phytoecdysteroids of plants of the genusAjuga and their biological activity 1. Distribution and chemical structures of the compounds isolated

Saatov, Z.; Сыров, В. Н.; Mamatkhanov, A. U.; Abubakirov, N. K.

doi:10.1007/bf00629994

Cited by 10 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ajuga species [1][2][3][4][5], and the available data are listed in Table 1. In this, the species names originally used by the authors have been used, but it may happen that some of them are synonymous.…”

Section: Previous Reviews Have Underlined the Diversity Of Ecdysteroids Inmentioning

confidence: 99%

Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota

Bakrim

Ngunjiri²,

Crouzet

et al. 2014

Natural Product Communications

View full text Add to dashboard Cite

Phytoecdysteroids are plant analogues of insect moulting hormones and are used by plants to repel or disturb phytophagous insects. They are also active on mammals and present in many plants used in traditional medicine. The Ajuga genus contains several such species, which occur in various pharmacopoeias. We report the isolation and identification of major and minor ecdysteroids present in two Ajuga species, A. iva and A. remota, both of which are used as medicinal plants in Africa. Three minor ecdysteroids (abutasterone, ponasterone A and sidisterone) have been found for the first time in the Ajuga genus.

show abstract

Section: Previous Reviews Have Underlined the Diversity Of Ecdysteroids Inmentioning

confidence: 99%

Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota

Bakrim

Ngunjiri²,

Crouzet

et al. 2014

Natural Product Communications

View full text Add to dashboard Cite

show abstract

“…However, there are exceptions within the aforementioned families, even within genera, specified as ecdysteroid-negative species. It is speculated that a majority of plants are theoretically able to synthesize ecdysteroids, but the responsible genes have been silenced, perhaps in favor of the interaction between plants and harmless or beneficial insects (such as pollinators) (Saatov et al 1994 , Lafont and Dinan 2003 ). Very few of the crop species are ecdysteroid-positive, which limits the possible dietary sources of ecdysteroids.…”

Section: Present Sources Of Ecdysteroidsmentioning

confidence: 99%

“…and Schult.f. and C. arachnoidea C.B.Clarke, and several species from ferns belonging to Polypodium are used as a source of an ecdysteroid-rich extract (Saatov et al 1994 ; Messeguer et al 1998 ; Borovikova and Baltaev 1999 ; Lafont and Dinan 2003 ).…”

Section: Present Sources Of Ecdysteroidsmentioning

confidence: 99%

Ecdysteroids: production in plant in vitro cultures

et al. 2016

View full text Add to dashboard Cite

Ecdysteroids are secondary metabolites, widely distributed in the animal and plant kingdoms. They have a wide range of pharmacological effects in vertebrates, including mammals, most of which are beneficial for humans. Therefore, they have become compounds of interest for the pharmaceutical industry due to their adaptogenic, anabolic, hypoglycaemic, hypocholesterolaemic and antimicrobial activities, which are still being researched. Nowadays, ecdysteroids are present as active ingredients in bodybuilding supplements. Because of their complex structures, their chemical synthesis seems unprofitable and impractical. Due to high content of ecdysteroids in many plants, they are primarily obtained by extraction of the plant material. Plant in vitro cultures provide an alternative source of these compounds, helping to avoid problems associated with field production—such as variable yield or dependence on environmental factors, as well as limited availability of natural resources. Plant cell and tissue cultures may be suggested as alternatives for the production of plant biomass rich in pharmaceutically active ecdysteroids. Moreover, the use of common biotechnological strategies, such as elicitation or precursor feeding, may further increase the yield and improve production of these compounds. In this paper, we describe general information about ecdysteroids: their structure, biosynthesis, distribution, role in plants, and we review recent studies on micropropagation of ecdysteroid-producing plants and cell cultures, and potential ability of ecdysteroids enhancement in in vitro cultures.

show abstract

“…Among the > 300 known species of the genus Ajuga (Lamiaceae), ≥ 45 have been chemically investigated (Mamadalieva, 2013;Saatov et al, 1994). A few of these have been studied in the context of their medical properties, owing to the presence of active molecules such as phytoecdysteroids, diterpenoids, sterols, iridoids, neoclerodanes, anthocyanins, other flavonoids and ionones (Israili and Lyoussi, 2009;Mamadalieva et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

The minor ecdysteroids from Ajuga turkestanica

Guibout

Mamadalieva

Balducci

et al. 2015

Phytochemical Analysis

View full text Add to dashboard Cite

Ajuga turkestanica ecdysteroids are characterised by the abundance of 11α-hydroxylated compounds and by the simultaneous presence of 24C, 27C, 28C and 29C ecdysteroids. It is expected that even more ecdysteroids are to be found in this plant since the starting material for this study lacked the less polar ecdysteroids. The simultaneous presence of 20-hydroxyecdysone and turkesterone (its 11α-hydroxy analogue) as the two major ecdysteroids suggests that every ecdysteroid is probably present in both 11α-hydroxy and 11-deoxy forms.

show abstract

Phytoecdysteroids of plants of the genusAjuga and their biological activity 1. Distribution and chemical structures of the compounds isolated

Cited by 10 publications

References 20 publications

Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota

Ecdysteroid Profiles of Two Ajuga species, A. iva and A. remota

Ecdysteroids: production in plant in vitro cultures

The minor ecdysteroids from Ajuga turkestanica

Contact Info

Product

Resources

About