Phytoestrogens, endocrine disrupters from food

Bennetau-Pelissero, Catherine; Latonnelle, K.; Sequeira, Ana; Lamothe, Valérie

doi:10.1051/analusis:2000280763

Cited by 13 publications

(7 citation statements)

References 111 publications

(144 reference statements)

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“…This is the case for soyabean isoflavones (mainly genistein, daidzein and glycitein) as well as flavonoids such as luteolin and naringenin that exhibit oestrogenic properties ( 53 ) . These phytochemicals play a role as partial agonists and/or antagonists of oestrogen receptors and can modulate the oestrogen-dependent pathway ( 54 ) .…”

Section: Polyphenols: Structure Metabolism and Cellular Bioactivitiesmentioning

confidence: 99%

When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

2009

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Recent research has provided insights into dietary components that may optimise bone health and stimulate bone formation. Fruit and vegetable intake, as well as grains and other plant-derived food, have been linked to decreased risk of major chronic diseases including osteoporosis. This effect has been partially attributed to the polyphenols found in these foods. Thus, it has been suggested that these compounds may provide desirable bone health benefits through an action on bone cell metabolism. The present review will focus on how some polyphenols can modulate osteoblast function and reports which cellular signalling pathways are potentially implicated. However, to date, despite numerous investigations, few studies have provided clear evidence that phenolic compounds can act on osteoblasts. Polyphenols cited in the present review seem to be able to modulate the expression of transcription factors such as runt-related transcription factor-2 (Runx2) and Osterix, NF-κB and activator protein-1 (AP-1). It appears that polyphenols may act on cellular signalling such as mitogen-activated protein kinase (MAPK), bone morphogenetic protein (BMP), oestrogen receptor and osteoprotegerin/receptor activator of NF-κB ligand (OPG/RANKL) and thus may affect osteoblast functions. However, it is also important to take in account the possible interaction of these compounds on osteoclast metabolism to better understand the positive correlation reported between the consumption of fruit and vegetables and bone mass.

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Section: Polyphenols: Structure Metabolism and Cellular Bioactivitiesmentioning

confidence: 99%

When nutrition interacts with osteoblast function: molecular mechanisms of polyphenols

2009

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“…Melting points were determined with a Stuart Scientific melting point apparatus SMP3 and are uncorrected. 1 H and 13 C NMR spectra were recorded with a Bruker AC-300 FT ( 1 H, 300 MHz; 13 C, 75 MHz) or with a Bruker AC 250 ( 1 H, 250 MHz; 13 C, 63 MHz) using TMS as an internal standard. The chemical shifts (δ) and coupling constants (J) are respectively expressed in parts per million and hertz.…”

Section: Chemicalsmentioning

confidence: 99%

“…Glycitein (4′,7-dihydroxy-6-methoxyisoflavone) is present in soy and soy-based foods together with genistein and daidzein and their glycosylated forms. All of these substances are known as estrogenic compounds capable of interacting with estradiol receptors (ER) (1). Glycitein contents range from 5 to 10% of total isoflavones in soybeans (2) and can reach 50% in soy germ (3).…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Haptens and Conjugates for ELISA of Glycitein: Development and Validation of an Immunological Test

Shinkaruk

Lamothe

Schmitter

et al. 2008

J. Agric. Food Chem.

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Two carboxylic acid haptens of glycitein were synthesized, with a spacer arm at the C2 position. They differed in the length of the spacer arm, with the length of the spacer arms being three or four carbon atoms, and were named Delta3-glycitein and Delta4-glycitein haptens, respectively. The different haptens were coupled to bovine serum albumin (BSA), and the coupling efficiency was assessed by MALDI mass spectrometry. Polyclonal antibodies were generated against the BSA conjugates. An additional conjugate of Delta4-glycitein hapten was generated with swine thyroglobulin (Thyr). Enzyme-linked immunosorbent assays (ELISAs) based on the competition between free glycitein and Delta4-glycitein-Thyr conjugates for specific antibodies were developed. The IC50 of the standard curves was 15.6 ng mL(-1) with anti-Delta3-glycitein and 62.5 ng mL(-1) with anti-Delta4-glycitein, that is, 10.9 and 44 pmol/well, respectively. With the Delta3-glycitein antibody, interassay and intra-assay variations were 12.2 and 11.5%, respectively. Specificity tests did not show any significant cross-reaction with any other soy isoflavone. This specificity is not influenced by the length of the spacer arm. The assay was validated by measurements performed on plasma samples as well as on soy-based foodstuffs and on soy-based food supplements.

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“…Cependant, plusieurs de ces résultats font l'objet de controverses et quelques auteurs ont souligné l'absence d'études complètes de toxicité des PO, sans lesquelles il ne peut être établi de réelle analyse risques/bénéfices de tels composés pour l'homme. Les niveaux mesurés dans le lait de soja peuvent dépasser 200 mg/l [31] et plusieurs préparations à base de soja atteignent des teneurs supérieures à 500 mg/kg [32]. Ces aliments conduisent à des ingestions quotidiennes qui sont de l'ordre de 30 à 50 mg d'isoflavones, c'est-à-dire identiques à celles des préparations préconisées chez les femmes ménopausées.…”

Section: Phyto-oestrogènesunclassified