Phytoestrogens oestrogen synthesis and breast cancer

Rice, Suman; Whitehead, Saffron

doi:10.1016/j.jsbmb.2007.09.003

Cited by 42 publications

(34 citation statements)

References 94 publications

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“…Phytoestrogens are thought to protect from bone loss mainly through estrogen dependent mechanisms as phytoestrogens seemed to directly increase estrogen levels, as seen in the present study and in other investigations (Rice and Whitehead 2008). Phytoestrogens associated estrogen raise may be related to their structural similarity to estrogens at the molecular level which may help to exert estrogen like activities.…”

Section: Discussionsupporting

confidence: 81%

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

2013

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The purpose of the present study was to investigate the osteoprotective effects of soybean oil (SbO) and sesame oil (SO) in ovarictomized (OVX) rats. The results indicated that the OVX rats exhibited a significant decrease in Ca and P level in both serum and bone, the activities of the antioxidant enzymes SOD and CAT and the antioxidant biomarker GSH accompanied with a marked increase in the oxidative stress markers MDA and PC, the inflammatory indices (TNF-a, CRP levels, WBCs counts and ACP activity) in, both, bone and serum. Supplementating the diet of the OVX rats with SbO (15 % w/w) or SO (10 % w/w) for 2 months to resulted in modulation of the alterations in all tested parameters and succeeded to restore minerals, antioxidant enzymes, antioxidant biomarkers, oxidative stress markers, inflammatory indices, and WBCs counts. It could be concluded that the consumption of diets supplemented with SbO or SO might be useful for preventing bone loss caused by estrogen deficiency in ovariectomy status.

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Section: Discussionsupporting

confidence: 81%

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

2013

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“…Flavonoids have many biological effects that may play a role in BC prevention, including a reduction of reactive oxygen species production, antimutagenic and antiproliferative properties, regulation of cell signalling and cell cycle, and inhibition of angiogenesis [5,6]. In addition, phyto-oestrogens, such as isoflavones and lignans, have a weak oestrogen-like activity; therefore phyto-oestrogens could interact with oestrogen receptors in the development of BC [7,8].…”

Section: Introductionmentioning

confidence: 99%

Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Zamora-Ros

Ferrari

González

et al. 2013

Breast Cancer Res Treat

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“…There are experimental evidences for and against the action of phytoestrogens as promoters or protectants of breast cancer (for review [4]). Since many in vitro studies have used a similar cellular background (MCF-7) and experimental conditions, the discrepancies in the findings are puzzling.…”

Section: Introductionmentioning

confidence: 99%

Respective contribution exerted by AF‐1 and AF‐2 transactivation functions in estrogen receptor α induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation

Carreau

Flouriot

Bennetau-Pelissero

et al. 2009

Molecular Nutrition Food Res

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Estrogens used in hormone replacement therapy regimens may increase the risk of developing breast cancer. Paradoxically, high consumption of plant-derived phytoestrogens, particularly soybean isoflavones, is associated with a low incidence of breast cancer. To explore the molecular basis for these potentially different experimental/clinical outcomes, we investigated whether soybean isoflavones elicit distinct transcriptional actions from estrogens by performing transient transfections in different cell lines. Our results demonstrate that 17beta estradiol (E2), isoflavones, and equol (EQ) effectively trigger the transcriptional activation with both estrogen receptors (ER), ER alpha and ER beta. ER alpha transcriptional activity is mediated through two transactivation domains AF-1 and AF-2, whose activity is tightly regulated in a cell-type and promoter-specific manner. Isoflavones, genistein, and daidzein (DAI), and EQ, the main estrogenic metabolite of DAI, are ER alpha agonists for transcriptional activation. The molecular mechanisms for ER alpha-induced transcriptional activity by isoflavones and EQ involve their capacity to act mainly through AF-1 regardless of the cell type. Therefore, our data indicate that estrogenic ligands, such as isoflavones and EQ, exert their effects on ER alpha transactivation similarly to the endogenous ligand E2, and suggest that the risk of estrogen-related diseases might not be reduced by soy-rich food and/or isoflavone- or EQ-based supplements.

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Phytoestrogens oestrogen synthesis and breast cancer

Cited by 42 publications

References 94 publications

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

Osteoprotective effect of soybean and sesame oils in ovariectomized rats via estrogen-like mechanism

Dietary flavonoid and lignan intake and breast cancer risk according to menopause and hormone receptor status in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Respective contribution exerted by AF‐1 and AF‐2 transactivation functions in estrogen receptor α induced transcriptional activity by isoflavones and equol: Consequence on breast cancer cell proliferation

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