Phytomedicinal and Nutraceutical Benefits of the GC-FID Quantified Phytocomponents of the Aqueous Extract of Azadirachta indica leaves

Ugoeze, Kenneth Chinedu; Oluigbo, Kennedy Emeka; Chinko, Bruno Chukwuemeka

doi:10.26502/fjppr.039

Cited by 14 publications

(67 citation statements)

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“…Saponins have been reported to have antibacterial, antiviral, anti-fungal, anti-inflammatory, and immunomodulatory properties. [61,62] Therefore, saponins may improve the treatment of FOS-associated diseases such as hypertensive disease, reperfusion injury, and hyperalgesia. However, the specific underlying mechanisms require further investigation.…”

Section: Discussionmentioning

confidence: 99%

Time-series analysis of hematopoietic stem cells

Han,

Duan,

et al. 2024

Medicine

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This study aimed to investigate the molecular mechanisms underlying the aging of hematopoietic stem cells (HSCs). Gene expression profile GSE32719 was downloaded from the Gene Expression Omnibus database, including 14 young, 5 middle, and 8 old HSCs. Differential expression analysis, short time-series expression miner analysis, and weighted co-expression network analysis were conducted to screen for hub genes whose expression changed over time during HSC aging. Subsequently, functional enrichment and multiple regulatory network analyses of the hub genes were performed. A total of 124 intersecting time-dependent differentially expressed and module genes were obtained, which were considered hub genes whose expression changed over time during HSC aging. Hub genes were significantly enriched in pathways such as the Hippo and AMP-activated protein kinase (AMPK) signaling pathways. Moreover, AP-1 Transcription Factor Subunit (FOS) and sirtuin 1 (SIRT1) had higher degrees in the protein-protein interaction network, were regulated by more transcription factors (TFs), such as Sp1 transcription factor (SP1) and BRCA1 DNA repair-associated (BRCA1), in the TF-mRNA-miRNA network, were associated with more diseases in the disease-gene network, and could be targeted by more drugs in the drug-gene network. Furthermore, SIRT1 was targeted by miR-9-5p in the TF-mRNA-miRNA network. Hub genes such as FOS and SIRT1 and key pathways such as the Hippo and AMPK signaling pathways may play crucial roles in HSC aging. Moreover, FOS and SIRT1 were regulated by SP1 and BRCA1, respectively, during HSC aging. Furthermore, miR-9-5p may modulate HSC aging by targeting SIRT1. Thus, FOS and SIRT1 may be potential therapeutic targets for age-related hematopoietic dysfunction.

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Section: Discussionmentioning

confidence: 99%

Time-series analysis of hematopoietic stem cells

Han,

Duan,

et al. 2024

Medicine

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“…These groups and specific phytochemicals have been reported to possess various medicinal and therapeutic potentials. Flavonoids are well known for their valuable health benefits especially with their attributable anti-oxidative, antimutagenic, anti-inflammatory, anti-carcinogenic, antipyretic, hypoglycemic, antifungal, antibacterial, anti-tumour and wound healing properties [14] it also has enzyme modulatory functions [15,16] . Proanthocyanin and anthocyanin serve as stress protectants and health-promoting components because of their potent antioxidant activity [17] .…”

Section: Discussionmentioning

confidence: 99%

“…It has also been implicated with anti-microbial activity [32,33] . Cathechin possesses enormous health benefits such as anti-obesity, anticancer, hepatoprotective, and antidiabetic and neuro-protective effects while epicatechins are known to possess cardio-protective, antioxidant, anti-diabetic and anti-cancer activities [14] . Tannins are used as astringent as well as a diuretic.…”

Section: Discussionmentioning

confidence: 99%

“…The oven operated initially at 200 o C, it was heated to 330 o C at a rate of 3 o C min -1 and was kept at this temperature for 5min. The detector operated at a temperature of 320 o C. Phytochemicals were determined by the ratio between the area and mass of internal standard and the area of the identified phytochemicals [11,13,14] .…”

Section: Gc-fid Identification and Quantification Of Phytochemical Constituentsmentioning

confidence: 99%

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GC-FID phytochemical analysis of selected antidiabetic herbal preparations sold in Onitsha metropolis, Anambra state, Nigeria

Ojukwu¹,

Onyegbule²,

Ce³

2021

J. Med. Plants Stud.

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Diabetes has become one of the world's most serious public health problems. The importance of plant extracts in diabetes management is widely acknowledged. This study was designed to determine the phytochemical compositions of the selected herbal preparations, which is used for treatment of Diabetes in Nigeria. Standard method was employed and gas chromatography-flame ionization detector (GC-FID) instrument used for the analysis and quantification of phytochemicals present in the samples. The analyses revealed the presence of 23 bioactive compounds and they include; Proanthocyanin, Phytate,

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“…Thrombosis is the formation of a blood clot within a blood vessel, which can partially or completely obstruct blood flow leading to cardiovascular complications and death [38,39]. Due to the negative side effects, high cost, and limited availability of synthetic medications, the utilization of plant-derived natural substances derived from plants has increasingly gained popularity and has become the primary approach in human pharmacotherapy [40][41][42]. This has led to the screening of possible natural antithrombotic agents derived from natural products.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Haemostatic Effects of Petroselinum crispum (Parsley) in Wistar Rats

Anyanwu

Chinko

2023

IBRR

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Petroselinum crispum (parsley or garden parsley), besides its use as an edible vegetable, is used in the treatment of various ailments with documented evidence validating some of these medicinal uses. The present study evaluates the impact of oral administration of P. crispum on blood coagulation parameters. Fresh leaves of P. crispum were locally sourced, authenticated and extracted using ethanol to obtain an ethanolic extract of P. crispum (PCE). Twenty-five (25) male Wistar rats were used for the study and were randomly assigned to five (5) animals of five (5) rats each. Group I served as the control group and was given distilled water, whereas groups II, III, and IV were treated as experimental groups and administered PCE at 200, 400, and 800mg/kg via oral gavage, respectively. Group V also received 800mg/kg of PCE with the administration terminated on the 28th day to allow for a 14-day recovery period. Platelet count (PLT) and other platelet indices were determined using an automated Haematology analyzer. Bleeding time (BT), clotting time (CT), prothrombin time (PT), activated partial thromboplastin time (aPTT) and plasma fibrinogen (FIB) were assayed following standard laboratory protocols. The results of the study show that the mean PLT were significantly reduced in the experimental animals compared to the control (p<0.05) while BT, CT, PT, aPTT and FIB significantly increased compared to the control (p<0.05). Also, BT, CT, PT, and aPTT recovered towards the control values after the 14-day withdrawal period. The present study shows ethanolic leaf extract of P. crispum prolonged blood coagulation. The current evidence suggests that P. crispum could be a candidate for further exploration as a natural plant-based antithrombotic agent.

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Phytomedicinal and Nutraceutical Benefits of the GC-FID Quantified Phytocomponents of the Aqueous Extract of Azadirachta indica leaves

Cited by 14 publications

References 0 publications

Time-series analysis of hematopoietic stem cells

Time-series analysis of hematopoietic stem cells

GC-FID phytochemical analysis of selected antidiabetic herbal preparations sold in Onitsha metropolis, Anambra state, Nigeria

Evaluation of Haemostatic Effects of Petroselinum crispum (Parsley) in Wistar Rats

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