Phytomedicines in the Treatment of Migraine

Rajapakse, Thilinie; Davenport, William Jeptha

doi:10.1007/s40263-018-0597-2

Cited by 37 publications

(21 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The disease begins in childhood, with a tendency to worsen during adulthood (22-55 years of age). Women experience a higher incidence compared to men (3:1) [1]. Serotonin (5-HT) depletion and trigemino-vascular system activation are notoriously involved in migraine pathophysiology [2][3][4][5][6], although the origin site and mechanisms at the basis of migraine are still a matter of debate.…”

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Neuromodulatory Effects Induced by Tanacetum parthenium Water Extract: Results from In Silico, In Vitro and Ex Vivo Studies

et al. 2020

View full text Add to dashboard Cite

Tanacetum parthenium (feverfew) has traditionally been employed as a phytotherapeutic remedy in the treatment of migraine. In this study, a commercial T. parthenium water extract was investigated to explore its anti-inflammatory and neuromodulatory effects. Isolated mouse cortexes were exposed to a K+ 60 mM Krebs-Ringer buffer and treated with T. parthenium water extract. The prostaglandin E2 (PGE2) level, brain-derived neurotrophic factor (BDNF), interleukin-10 (IL-10), and IL-1β gene expression were evaluated in the cortex. The effects on dopamine (DA) release and dopamine transporter (DAT) gene expression were assayed in hypothalamic HypoE22 cells. A bioinformatics analysis was conducted to further investigate the mechanism of action. The extract was effective in reducing cortex PGE2 release and IL-1β gene expression. In the same experimental system, IL-10 and BDNF gene expressions increased, and in HypoE22 cells, the extract decreased the extracellular dopamine level and increased the DAT gene expression due to the direct interaction of parthenolide with the DAT. Overall, the present findings highlight the efficacy of T. parthenium water extract in controlling the inflammatory pathways that occur during cortical-spreading depression. Additionally, the inhibition of the hypothalamic DA release observed in this study further supports the role of dopaminergic pathways as key targets for novel pharmacological approaches in the management of migraine attacks.

show abstract

Section: Introductionmentioning

confidence: 99%

Anti-Inflammatory and Neuromodulatory Effects Induced by Tanacetum parthenium Water Extract: Results from In Silico, In Vitro and Ex Vivo Studies

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Those who experience sporadic migraine attacks usually need rescue medication to stop the pain [37]. However, due to the side effects reported when using the standard prophylactic medication (antiepileptic drugs, calcium channel inhibitors) [38,39] or abortive therapy, the discovery of substances with a more gentle effect and better tolerance is still required, i.e., causing less side effects [40]. Given the prevalence of migraine in children, this issue is of particular relevance [41].…”

Section: Migraine and Plant Antioxidantsmentioning

confidence: 99%

The Use of Antioxidants in the Treatment of Migraine

et al. 2020

View full text Add to dashboard Cite

Despite numerous studies concerning the pathophysiology of migraine, the exact molecular mechanism of disturbances underlying migraine is still unknown. Furthermore, oxidative stress is considered to play a significant role in migraine pathogenesis. The notion of oxidative stress in migraine patients has been discussed for several decades. Over the past few years, among the substances that could potentially be used for migraine treatment, particular attention has been paid to the so-called nutraceutics, including antioxidants. Antioxidants supplied with food prevent oxidative stress by inhibiting initiation, propagation, and the oxidative chain reaction itself. Additionally, the agents used so far in the prevention of migraine indeed show some anti-oxidative action. The antioxidants discussed in the present paper are increasingly more often used by migraine patients not only due to mild or even a lack of side effects but also because of their effectiveness (decreased frequency of migraine episodes or shortening of an episode duration). The present review provides a summary of the studies on nutraceuticals with antioxidative properties.

show abstract

“…On the other hand, some studies suggested that the inhibitory ability of hypericin's on MAO was lower than what was expected before. Moreover, the sufficient levels of hypericin that are necessary to inhibit the MAO significantly were far higher than the levels that can be found in the tissue of the human brain at normal doses [5] [6]. Other studies showed that hypericin have a high affinity for the sigma receptors that in turn regulate the dopamine levels.…”

Section: Introductionmentioning

confidence: 96%

“…Other studies showed that hypericin have a high affinity for the sigma receptors that in turn regulate the dopamine levels. It also serve as an antagonist some receptors such as, the gamma aminobutyric acid (GABA), benzodiazepine, inositol triphosphate, and adenosine receptors, which in turn regulate the resultedaction potentials fromthe neurotransmitters activity [6] [7]. In spite of the antidepressant properties of the hypericin, it cannot ISSN: 2349-8889 Volume-8, Issue-1 (January 2021) https://doi.org/10.31033/ijrasb.8.…”

Section: Introductionmentioning

confidence: 99%

Impact of Water and Alcoholic Plant Extracts of Hypericum perforatum on Histological and Some Physiological Features in the Liver of Albino Rats

Hameed¹,

Rashid²,

Hameed³

2021

Int. j. res. appl. sci. biotechnol.

View full text Add to dashboard Cite

Hypericum perforatum, which is known as St. John’s wort (SJW), is a leafy herb that grows in the open areas of the temperate regions throughout the world. Recent research suggests the effectiveness of this plant in treating some diseases, such as cancer, bacterial and viral diseases, and some inflammation-related disorders, and as a neuroprotective agent and an antioxidant. The current study aimed to investigate the Impact of water and alcoholic plant extracts of H. perforatum on histological and some physiological features in the liver of albino rats. 21 male rats were used in the current study. They were divided into groups; each group contains 7 members of animals. The animals were raised a month ago in the animal house before conducting the study to ensure their suitability to the environment of the animal house. Before the start of the study, an appropriate amount of animal blood was obtained through the caudate vein of rats, in order to evaluate the variables of the physiological study before starting treatment with plant extracts. One of the groups (Group 1) was used as a standard control group, receiving only standard water and feed. The other group (Group 2) was treated with St. John's water extract at a concentration of 300 mg/kg/body weight, while the last group (Group 3) was treated with St. John's alcoholic plant extract at a concentration of 300 mg/kg/body weight. Aqueous and alcoholic plant extract were prepared for H. perforatum. Histological slides were prepared from the liver of each group of the study as well as, alkaline phosphatase (ALP), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were evaluated for the rates in each group. Histological examination shows the presence of necrosis in various stages and the presence of Foamy Cells and the occurrence of infiltration of a number of inflammatory cells within the tissue as well as the occurrence of congestion in the central vein and hemorrhage spread throughout the rest of the tissue. We also note the occurrence of necrosis and desquamation of the central vein lining and infiltration of some inflammatory cells in some areas. The effect of treatments on the aminotransferases (AST, ALT) enzymes and the ALP, where appeared as a significant increase of 0.05 in their concentration when comparing the concentrations of each groups before and after treatment with plant extracts. We can conclude that H. perforatum aqueous and alcoholic plant extract can causes mild damages on liver histological features that can be reflected on livers physiological states generally and on the ALT, AST and ALP enzymes specifically.

show abstract

Phytomedicines in the Treatment of Migraine

Cited by 37 publications

References 105 publications

Anti-Inflammatory and Neuromodulatory Effects Induced by Tanacetum parthenium Water Extract: Results from In Silico, In Vitro and Ex Vivo Studies

Anti-Inflammatory and Neuromodulatory Effects Induced by Tanacetum parthenium Water Extract: Results from In Silico, In Vitro and Ex Vivo Studies

The Use of Antioxidants in the Treatment of Migraine

Impact of Water and Alcoholic Plant Extracts of Hypericum perforatum on Histological and Some Physiological Features in the Liver of Albino Rats

Contact Info

Product

Resources

About