Phytonanoparticles for the treatment of Alzheimer’s disease: A review

Abstract

Alzheimer's disease, (AD) is a neurodegenerative disease characterized by cognitive dysfunction and is an age-related disease. The neuropathology of AD is -amyloid (A) peptide in the brain and causes neurofibrillary tangles. The acetylcholine level is reduced in the hippocampus and acetylcholinesterase (AChE) is enhanced causing memory deterioration. Oxidative damage is one of the major cellular impacts affected during AD condition. Plant derived polyphenols are the compounds which are having remarkable effect of free radical scavenging effect and AChE inhibitory effect in brain. The treatment with phytocompounds were highly effective for neuroprotection and systematically regulates the brain organic balance. The limitations of phytocompounds to penetrate the blood brain barrier is majorly surpassed by the novel drug delivery systems such as nanoparticles. Nanoformulations of phytocompounds have a greatest potential for the target delivery of drugs to the brain and have maximal therapeutic effect. This review states the remarkable impacts of selected phytonanoparticles for the treatment of AD.