Phytopharmacologic studies of Ipomoea muricata seeds

Gupta, Manu; Tewari, J. P.; Khanna, S. N.; Gupta, Priyanka; Srivastava, Mayank; Mishra, Shashank Shekhar

doi:10.1002/jps.2600560629

Cited by 10 publications

(4 citation statements)

References 2 publications

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“…Many species of Ipomoea were and often still are used in folk medicine in different parts of the world, − especially as purgatives . Pharmacological studies on extracts of these plants have reported antimicrobial, analgesic, spasmogenic, spasmolytic, hypotensive, psychotomimetic, and anticancer effects .…”

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confidence: 99%

Structural Investigation of Resin Glycosides from Ipomoea lonchophylla

MacLeod

Ward

Oelrichs³

1997

J. Nat. Prod.

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A fraction from Ipomoea lonchophylla, which was toxic to mice, contained an inseparable mixture of resin glycosides with differing numbers of C5 ester groups on the hexasaccharide chain. After alkaline hydrolysis of the esters, the structure of the major component (1) was elucidated using high-field NMR spectroscopy, mass spectrometry, chemical studies, and comparison with known resin glycosides. Compound 1 was identified as 3,11-dihydroxytetradecanoic acid 11-O-beta-quinovopyranosyl-(1-->2)-beta-glucopyranosyl-(1-->3)- [alpha-rhamnopyranosyl- (1-->4)]-quinovopyranosyl-(1-->2)-beta-glucopyranosyl-(1-->2)-beta -fucopyranoside.

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confidence: 99%

Structural Investigation of Resin Glycosides from Ipomoea lonchophylla

MacLeod

Ward

Oelrichs³

1997

J. Nat. Prod.

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“…Alkaloids, phenolic compounds and glycolipids are the most common biologically active constituents found in the plant extracts. [ 1 2 3 4 5 6 ]…”

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confidence: 99%

Classical taxonomy studies of medicinally important Ipomoea leari

Porwal¹,

Gupta²,

Nanjan³

et al. 2015

Ancient Sci Life

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Background:Ipomoea leari which belongs to the family Convolvulaceae is an unexplored medicinal plant in the Indian medicinal system. According to ethnobotanical information, the whole plant is used for various disorders such as anti-inflammatory, psychotomimetic and anticancer activities. The current study seeks to standardize the parameters for this herb.Materials and Methods:The identification of the pharmacognostical, morphoanatomical characters of Ipomoea leari (leaf, stem and root) were carried out in terms of organoleptic, macroscopic, microscopic, physicochemical, florescence and phytochemical analyses. Physicochemical parameters such as total ash, moisture content and extractive values were determined by World Health Organization (WHO) guidelines. The plant material was fixed in formalin-5 mL + acetic acid-5 mL + 70% ethyl alcohol-9 mL (FAA) and dehydrated with graded series of tertiary-butyl alcohol. Toluidine blue, a polychromatic stain was used for staining the sections and then whole components were observed with Nikon lab photo device with microscopic units.Results:Microscopically, leaf consists of prominent midrib and the lamina, both having dorsiventral symmetry. The stomata are actinocytic. The stem consists of an epidermal layer of one cell thickness, wide cortex, vascular cylinder and wide pith. The root measuring 1.6 mm thick was studied. It consists of uniformly thick and continuous periderm, wide cortex and thick vascular cylinder. Qualitative analysis revealed the presence of carbohydrates, flavonoids, glycosides, steroids and phenols. The pharmacognostic studies were carried out in terms of macroscopic, phytoconstituent and chromatographic analyses of Ipomoea leari. Various standard methods were adopted to carry out the investigation.Conclusion:The results of the present study provide valuable pharmacognostic information of Ipomoea leari for its identification. Our result's suggest that Ipomoea leari is a promising candidate as an adjuvant therapy in various disorders and preparation of monograph.

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“…e seeds of I. muricata also contain resin glycosides which are laxative [1]. It also contains muricatin which gives cardiac depressant properties [9]. Recently, bioenhancing potential of Lysergol has been explored from in vitro studies, where it facilitated the transport of the antibiotics across the membrane for better efficacy on the target site [4].…”

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confidence: 99%

Isolation and TLC Densitometric Quantification of Lysergol from the Seeds of Ipomoea muricata (Linn.) Jacq.

Patil¹,

Nivsarkar

Anandajiwala³

2013

ISRN Chromatography

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Seeds of Ipomoea muricata, well known in Ayurveda for its purgative action, contains mainly indole alkaloids. Lysergol (major alkaloid) exhibits hypotensive, psychotropic, and uterus and intestine-stimulating properties. TLC fingerprint profile of I. muricata seeds was developed using chloroform : methanol (95 : 5 v/v) as the mobile phase. Plate was visualized under UV 254 nm and UV 366 nm and after derivatization with Van Urk reagent. Lysergol resolved at . Further, TLC-densitometric method was developed and validated for quantification of Lysergol avoiding derivatization step. Ethyl acetate : methanol (7 : 3 v/v) was used as the mobile phase. Linear regression analysis data for the calibration curve showed a good linear relationship () in the concentration range from 20 ng to 140 ng, with respect to the peak area. The developed method was precise with RSD for intraday (range from 1.20 to 1.89) and interday (range from 1.39 to 1.92) for 60, 80, and 100 ng/spot of Lysergol. The instrumental precision was 0.67 (% RSD). The limit of detection and limit of quantification for Lysergol were 12 ng and 40 ng, respectively. The average percentage recovery was 99.68. The amount of Lysergol was found to be 0.23% w/w. To the best of our knowledge, this is the first report for the quantification of Lysergol from I. muricata seeds without derivatization.

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Phytopharmacologic studies of Ipomoea muricata seeds

Cited by 10 publications

References 2 publications

Structural Investigation of Resin Glycosides from Ipomoea lonchophylla

Structural Investigation of Resin Glycosides from Ipomoea lonchophylla

Classical taxonomy studies of medicinally important Ipomoea leari

Isolation and TLC Densitometric Quantification of Lysergol from the Seeds of Ipomoea muricata (Linn.) Jacq.

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