Phytopharmacological Evaluation of Momordica balsamina Linn. From Southern Haryana, India

Singh, Sumitra; Devi, Bhagwati

doi:10.31872/2018/kjphc-100112

Cited by 4 publications

(3 citation statements)

References 20 publications

(25 reference statements)

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“…Bioflavonoids are remarkable for their hypoglycaemic abilities ( Vinayagam and Xu, 2015 ). It has been exhibited that flavonoids can go about as “insulin secretagogue or insulin-mimetic agents” ( Patel et al , 2012 ; Singh and Sahu, 2018 ).…”

Section: Biochanin-a and Its Pharmacological Benefitsmentioning

confidence: 99%

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Anuranjana,

Beegum,

K.P

et al. 2023

F1000Res

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This review was aimed at summarizing the cellular and molecular mechanisms behind the various pharmacological actions of biochanin-A. Many studies have been reported claiming its application in cancers, metabolic disorders, airway hyperresponsiveness, cardiac disorders, neurological disorders, etc. With regard to hormone-dependent cancers like breast, prostate, and other malignancies like pancreatic, colon, lung, osteosarcoma, glioma that has limited treatment options, biochanin-A revealed agreeable results in arresting cancer development. Biochanin-A has also shown therapeutic benefits when administered for neurological disorders, diabetes, hyperlipidaemia, and other chronic diseases/disorders. Isoflavones are considered phenomenal due to their high efficiency in modifying the physiological functions of the human body. Biochanin-A is one among the prominent isoflavones found in soy (glycine max), red clover (Trifolium pratense), and alfalfa sprouts, etc., with proven potency in modulating vital cellular mechanisms in various diseases. It has been popular for ages among menopausal women in controlling symptoms. In view of the multi-targeted functions of biochanin-A, it is essential to summarize it's mechanism of action in various disorders. The safety and efficacy of biochanin-A needs to be established in clinical trials involving human subjects. Biochanin-A might be able to modify various systems of the human body like the cardiovascular system, CNS, respiratory system, etc. It has shown a remarkable effect on hormonal cancers and other cancers. Many types of research on biochanin-A, particularly in breast, lung, colon, prostate, and pancreatic cancers, have shown a positive impact. Through modulating oxidative stress, SIRT-1 expression, PPAR gamma receptors, and other multiple mechanisms biochanin-A produces anti-diabetic action. The diverse molecular mechanistic pathways involved in the pharmacological ability of biochanin-A indicate that it is a very promising molecule and can play a major impact in modifying several physiological functions.

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Section: Biochanin-a and Its Pharmacological Benefitsmentioning

confidence: 99%

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Anuranjana,

Beegum,

K.P

et al. 2023

F1000Res

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“…The powdered plant material (500 g) was extracted with ethanol using Soxhlet apparatus 10 . The extract obtained was concentrated by distilling off the solvent and recovering the same.…”

Section: Preparation Of Extractmentioning

confidence: 99%

“…Preliminary Phytochemical Screening: Various chemical tests were performed 10,11 using dried ethanol and aqueous extracts to detect the presence of phytoconstituents like carbohydrates, alkaloids, glycosides, phenols, tannins, flavonoids, and saponins.…”

Section: Preparation Of Extractmentioning

confidence: 99%

Untitled

2020

IJPSR

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The present study was aimed to evaluate the in-vitro antiinflammatory activity of fruits and leaves extract of Cucumis melo L. subsp. agrestis (Naudin) Pangalo (Family Cucurbitaceae). The ethanol and aqueous extracts of fruits and leaves of the plant were subjected to preliminary phytochemical screening and in-vitro anti-inflammatory activity. Extracts were incubated with bovine albumin under controlled conditions for denaturation, and protein denaturation was calculated by determination of their absorbance. Since, the erythrocyte membrane is analogous to the lysosomal membranes and its stabilization implies that the extract may well stabilize lysosomal membranes thus human red blood cell membrane stabilization was used as a method to study the invitro anti-inflammatory activity. The results showed that the plant extracts showed anti-inflammatory activity in a concentration-dependent manner, and the activity was increased on increasing the concentration of extracts. The ethanol extract was found to be more effective than other extracts of fruit and leaf. The present study reveals that the fruit of Cucumis melo L. subsp. agrestis (Naudin) Pangalo possesses a higher anti-inflammatory than the leaf. The activity may be due to the presence of phenols, tannins, and flavonoids present in the plant.

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African Pumpkin (Momordica balsaminaL.)

Mashiane

Sivakumar

2022

Handbook of Phytonutrients in Indigenous Fruits and Vegetables

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Phytopharmacological Evaluation of Momordica balsamina Linn. From Southern Haryana, India

Cited by 4 publications

References 20 publications

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Mechanisms Behind the Pharmacological Application of Biochanin-A: A review

Untitled

African Pumpkin (Momordica balsaminaL.)

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