Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial

Pastorelli, Davide; Fabricio, Aline S C; Giovanis, Petros; D’Ippolito, Simona; Fiduccia, Pasquale; Soldà, Caterina; Buda, Andrea; Sperti, Cosimo; Bardini, Romeo; Dalt, Gianfranco Da; Rainato, Giulia; Gion, Massimo; Ursini, Fulvio

doi:10.1016/j.phrs.2018.03.013

Cited by 125 publications

(82 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Latest information on various preclinical and clinical anticancer trials using curcumin is reviewed in Doello et al (2018). Recently, in patients with locally advanced or metastatic pancreatic cancer, curcumin Meriva ® (2,000 mg/day) in complementary to gemcitabine was found to increase the efficacy of gemcitabine without any treatment-related toxicity (Pastorelli et al, 2018). Currently, a randomized, double-blind, placebo-controlled phase 2/3 trial is ongoing to determine the efficacy of curcumin (300 mg/i.v./day) along with Paclitaxel (80 mg/m2 BS; i.v.)…”

Section: Phytochemicals Evaluated In Clinical Trialsmentioning

confidence: 99%

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

et al. 2020

View full text Add to dashboard Cite

Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer progression has led to the development of a vast number of anticancer drugs. However, the use of chemically synthesized drugs has not significantly improved the overall survival rate over the past few decades. As a result, new strategies and novel chemoprevention agents are needed to complement current cancer therapies to improve efficiency. Naturally occurring compounds from plants known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, and podophyllotoxin analogs. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancer. The specific mechanisms include increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, induction of cell cycle arrest and apoptosis; and regulation of the immune system. The primary objective of this review is to describe what we know to date of the active compounds in the natural products, along with their pharmacologic action and molecular or specific targets. Recent trends and gaps in phytochemical based anticancer drug discovery are also explored. The authors wish to expand the phytochemical research area not only for their scientific soundness but also for their potential druggability. Hence, the emphasis is given to information about anticancer phytochemicals which are evaluated at preclinical and clinical level.

show abstract

Section: Phytochemicals Evaluated In Clinical Trialsmentioning

confidence: 99%

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

et al. 2020

View full text Add to dashboard Cite

show abstract

Section: Recent Clinical Trials On Curcuminmentioning

confidence: 99%

“…To address the low bioavailability of curcumin, a recent clinical trial investigated the combination of phospholipid-coated curcumin using nanotechnology and gemcitabine (111). Although the patient quality of life was not significantly improved during treatment, the patient drug response rate reached 27.3%, which was higher compared with the rate of 12% of gemcitabine alone, and the average progression-free survival and overall survival also reached 8.4 and 10.2 months, respectively (111). Therefore, curcumin combined with gemcitabine is may be a safe and effective therapy for wider application for pancreatic cancer treatment; however, before the combination of curcumin and gemcitabine therapy can become routine therapy for pancreatic cancer large multicentric randomized controlled trials need to be conducted.…”

Section: Recent Clinical Trials On Curcuminmentioning

confidence: 99%

The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review)

et al. 2020

View full text Add to dashboard Cite

Cancer is a harmful threat to human health. In addition to surgery, a variety of anticancer drugs are increasingly used in cancer therapy; however, despite the developments in multimodality treatment, the morbidity and mortality of patients with cancer patients are on the increase. The tumor-specific immunosuppressive microenvironment serves an important function in tumor tolerance and escape from immune surveillance leading to tumor progression. Therefore, identifying new drugs or foods that can enhance the tumor immune response is critical to develop improved cancer prevention methods and treatment. Curcumin, a polyphenolic compound extracted from ginger, has been shown to effectively inhibit tumor growth, proliferation, invasion, metastasis and angiogenesis in a variety of tumors. Recent studies have also indicated that curcumin can modulate the tumor immune response and remodel the tumor immunosuppressive microenvironment, indicating its potential in the immunotherapy of cancer. In this review, a brief introduction to the effects of curcumin on the tumor immune response and tumor immune microenvironment is provided and recent clinical trials investigating the potential of curcumin in cancer therapy are discussed.

show abstract

“…48 This same mechanism (a dissociation of the raptor protein from mTOR) is also responsible for rapamycin's inhibitory effects. 49 While numerous clinical trials have been conducted on curcumin supplementation, demonstrating anti-inflammatory or anticancer effects, [50][51][52][53][54][55][56] no human trials investigating a direct effect of curcumin on mTOR have been performed.…”

Section: Curcuminmentioning

confidence: 99%

Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1

Lucius

2020

Alternative and Complementary Therapies

View full text Add to dashboard Cite

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial

Cited by 125 publications

References 66 publications

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice

The roles of curcumin in regulating the tumor immunosuppressive microenvironment (Review)

Botanical Medicine and Phytochemicals in Healthy Aging and Longevity—Part 1

Contact Info

Product

Resources

About